Bifunctional magnetopolymersomes of iron oxide nanoparticles and carboxymethylcellulose conjugated with doxorubicin for hyperthermo-chemotherapy of brain cancer cells

2019 ◽  
Vol 7 (5) ◽  
pp. 2102-2122 ◽  
Author(s):  
Sandhra M. Carvalho ◽  
Alice G. Leonel ◽  
Alexandra A. P. Mansur ◽  
Isadora C. Carvalho ◽  
Klaus Krambrock ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Brain Cancer ◽  
Oxide Nanoparticles ◽  
Drug Nanocarriers

Magnetopolymersomes for potential multimodal brain cancer therapy – “nanoheaters meet drug nanocarriers”.

Antifolate-modified iron oxide nanoparticles for targeted cancer therapy: inclusion vs. covalent union

RSC Advances ◽  
2014 ◽  
Vol 4 (37) ◽  
pp. 19196-19204 ◽  
Author(s):  
K. A. López ◽  
M. N. Piña ◽  
R. Alemany ◽  
O. Vögler ◽  
F. Barceló ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Targeted Cancer Therapy

In this work four different iron oxide nanoparticles for the delivery of antitumoral drugs into cancer cells were synthesized and characterized.

Polymer Coated Iron Nanoparticles: Radiolabeling & In Vitro Studies

2020 ◽  
Vol 13 ◽  
Author(s):  
Selin Yılmaz ◽  
Çiğdem İçhedef ◽  
Kadriye Buşra Karatay ◽  
Serap Teksöz
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Cancer Cells ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Sem Images

Backgorund: Superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used for targeted drug delivery systems due to their unique magnetic properties. Objective: In this study, it’s aimed to develop a novel targeted 99mTc radiolabeled polymeric drug delivery system for Gemcitabine (GEM). Methods: Gemcitabine, an anticancer agent, was encapsulated into polymer nanoparticles (PLGA) together with iron oxide nanoparticles via double emulsion technique and then labeled with 99mTc. SPIONs were synthesized by reduction–coprecipitation method and encapsulated with oleic acid for surface modification. Size distribution and the morphology of the synthesized nanoparticles were caharacterized by dynamic light scattering(DLS)and scanning electron microscopy(SEM), respectively. Radiolabeling yield of SPION-PLGAGEM nanoparticles were determined via Thin Layer Radio Chromatography (TLRC). Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells in vitro. Results: SEM images displayed that the average size of the drug-free nanoparticles was 40 nm and the size of the drug-loaded nanoparticles was 50 nm. The diameter of nanoparticles were determined as 366.6 nm by DLS, while zeta potential was found as-29 mV. SPION was successfully coated with PLGA, which was confirmed by FTIR. GEM encapsulation efficiency of SPION-PLGA was calculated as 4±0.16 % by means of HPLC. Radiolabeling yield of SPION-PLGA-GEM nanoparticles were determined as 97.8±1.75 % via TLRC. Cytotoxicity of GEM loaded SPION-PLGA were investigated on MDA-MB-231 and MCF7 breast cancer cells. SPION-PLGA-GEM showed high uptake on MCF-7, whilst incorporation rate was increased for both cell lines which external magnetic field application. Conclusion: 99mTc labeled SPION-PLGA nanoparticles loaded with GEM may overcome some of the obstacles in anti-cancer drug delivery because of their appropriate size, non-toxic, and supermagnetic characteristics.

scholarly journals ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy

2020 ◽  
Vol Volume 15 ◽  
pp. 3333-3346 ◽  
Author(s):  
Srinivasan Ayyanaar ◽  
Chandrasekar Balachandran ◽  
Rangaswamy Chinnabba Bhaskar ◽  
Mookkandi Palsamy Kesavan ◽  
Shin Aoki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Iron Oxide Nanoparticles ◽  
Targeted Drug Delivery ◽  
Oxide Nanoparticles ◽  
Magnetic Iron Oxide Nanoparticles ◽  
Magnetic Iron Oxide ◽  
Targeted Drug

scholarly journals Size-Dependent Thermotherapy of Iron Oxide Nanoparticles on Human Breast Adenocarcinoma Cancer Cells

2013 ◽  
Vol 19 (S2) ◽  
pp. 218-219
Author(s):  
T. Mustafa ◽  
Y. Xu ◽  
F. Watanabe ◽  
Y. Zhang ◽  
M. Asar ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Breast Adenocarcinoma ◽  
Oxide Nanoparticles ◽  
Human Breast ◽  
Size Dependent ◽  
Human Breast Adenocarcinoma

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.

scholarly journals Dendrimer-Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells

2007 ◽  
Vol 17 (16) ◽  
pp. 3043-3050 ◽  
Author(s):  
S. H. Wang ◽  
X. Shi ◽  
M. Van Antwerp ◽  
Z. Cao ◽  
S. D. Swanson ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Specific Targeting

Preparation of epidermal growth factor (EGF) conjugated iron oxide nanoparticles and their internalization into colon cancer cells

2010 ◽  
Vol 322 (15) ◽  
pp. 2244-2250 ◽  
Author(s):  
Mar Creixell ◽  
Adriana P. Herrera ◽  
Vanessa Ayala ◽  
Magda Latorre-Esteves ◽  
Marianela Pérez-Torres ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Iron Oxide ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Colon Cancer Cells ◽  
Epidermal Growth
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