Facilely synthesized pH-responsive fluorescent polymer dots entrapping doped and coupled doxorubicin for nucleus-targeted chemotherapy

2017 ◽  
Vol 5 (16) ◽  
pp. 2921-2930 ◽  
Author(s):  
Yixiao Guo ◽  
Fengwen Cao ◽  
Yao Li ◽  
Liqin Xiong
Keyword(s):  
Targeted Drug Delivery ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Targeted Chemotherapy ◽  
Ph Responsive ◽  
Polymer Dots ◽  
Chemical Coupling ◽  
Delivery Platform ◽  
Targeted Drug ◽  
Fluorescent Polymer

The combination of physical doping and chemical coupling can significantly enhance the drug loading/release efficiency and improve the effect of cancer treatment. Based on this strategy, PEG-Dox doped and coupled PFBT polymer dots were optimized as a nucleus-targeted drug delivery platform for tumor therapy.

Design and synthesis of aptamer AS1411-conjugated EG@TiO2@Fe2O3 nanoparticles as a drug delivery platform for tumor-targeted therapy

2020 ◽  
Vol 44 (37) ◽  
pp. 15871-15886 ◽  
Author(s):  
Nahid Mansouri ◽  
Razieh Jalal ◽  
Batool Akhlaghinia ◽  
Khalil Abnous ◽  
Roya Jahanshahi
Keyword(s):  
Drug Delivery ◽  
Targeted Therapy ◽  
Sustained Release ◽  
Targeted Drug Delivery ◽  
Fe2o3 Nanoparticles ◽  
Ph Responsive ◽  
Release System ◽  
Design And Synthesis ◽  
Delivery Platform ◽  
Targeted Drug

AS1411@GMBS@EG@TiO2@Fe2O3 nanoparticle is an effective and safe pH-responsive sustained release system for targeted drug delivery into nucleolin-positive cells.

scholarly journals Conjugation of a smart polymer to doxorubicin through a pH-responsive bond for targeted drug delivery and improving drug loading on graphene oxide

RSC Advances ◽  
2021 ◽  
Vol 11 (31) ◽  
pp. 18809-18817
Author(s):  
Ali Bina ◽  
Heidar Raissi ◽  
Hassan Hashemzadeh ◽  
Farzaneh Farzad
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Ph Responsive ◽  
Smart Polymer ◽  
Anticancer Drug Delivery ◽  
Targeted Drug

Polymeric nanoparticles have emerged as efficient carriers for anticancer drug delivery because they can improve the solubility of hydrophobic drugs and also can increase the bio-distribution of drugs throughout the bloodstream.

scholarly journals Advanced Nano-Carriers for Anti-Tumor Drug Loading

2021 ◽  
Vol 11 ◽  
Author(s):  
Jia Xiang ◽  
Rui Zhao ◽  
Bo Wang ◽  
Xinran Sun ◽  
Xu Guo ◽  
...  
Keyword(s):  
Targeted Drug Delivery ◽  
Drug Loading ◽  
Tumor Therapy ◽  
Drug Efficacy ◽  
Research Progress ◽  
Delivery Methods ◽  
Important Means ◽  
Targeted Drug ◽  
Materials Used ◽  
Tumor Drugs

Chemotherapy is one of the important means of tumor therapy. However, most of the anti-tumor drugs that currently used in clinic are hydrophobic non-specific drugs, which seriously affect the efficacy of drugs. With the development of nanotechnology, drug efficacy can be improved by selecting appropriate biodegradable nanocarriers for achieving the controlled release, targeting and higher bioavailability of drugs. This paper reviewed the research progress of anti-tumor drug nanoparticle carriers, which mainly summarized the materials used for anti-tumor drug nanoparticle carriers and their effects in anti-tumor drugs, as well as the targeted drug delivery methods of anti-tumor drugs based on nanocarriers.

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

scholarly journals Folic Acid-Terminated Poly(2-Diethyl Amino Ethyl Methacrylate) Brush-Gated Magnetic Mesoporous Nanoparticles as a Smart Drug Delivery System

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 59
Author(s):  
Abeer M. Beagan ◽  
Ahlam A. Alghamdi ◽  
Shatha S. Lahmadi ◽  
Majed A. Halwani ◽  
Mohammed S. Almeataq ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Targeted Drug Delivery ◽  
Ph Responsive ◽  
Ethyl Methacrylate ◽  
Mesoporous Nanoparticles ◽  
Targeted Drug ◽  
Mcf 7

Currently, chemotherapy is an important method for the treatment of various cancers. Nevertheless, it has many limitations, such as poor tumour selectivity and multi-drug resistance. It is necessary to improve this treatment method by incorporating a targeted drug delivery system aimed to reduce side effects and drug resistance. The present work aims to develop pH-sensitive nanocarriers containing magnetic mesoporous silica nanoparticles (MMSNs) coated with pH-responsive polymers for tumour-targeted drug delivery via the folate receptor. 2-Diethyl amino ethyl methacrylate (DEAEMA) was successfully grafted on MMSNs via surface initiated ARGET atom transfer radical polymerization (ATRP), with an average particle size of 180 nm. The end groups of poly (2-(diethylamino)ethyl methacrylate) (PDEAEMA) brushes were converted to amines, followed by a covalent bond with folic acid (FA) as a targeting agent. FA conjugated to the nanoparticle surface was confirmed by X-ray photoelectron spectroscopy (XPS). pH-Responsive behavior of PDEAEMA brushes was investigated by Dynamic Light Scattering (DLS). The nanoparticles average diameters ranged from ca. 350 nm in basic media to ca. 650 in acidic solution. Multifunctional pH-sensitive magnetic mesoporous nanoparticles were loaded with an anti-cancer drug (Doxorubicin) to investigate their capacity and long-circulation time. In a cumulative release pattern, doxorubicin (DOX) release from nano-systems was ca. 20% when the particle exposed to acidic media, compared to ca. 5% in basic media. The nano-systems have excellent biocompatibility and are minimally toxic when exposed to MCF-7, and -MCF-7 ADR cells.

scholarly journals A pillar[5]arene-based [2]rotaxane lights up mitochondria

2016 ◽  
Vol 7 (5) ◽  
pp. 3017-3024 ◽  
Author(s):  
Guocan Yu ◽  
Dan Wu ◽  
Yang Li ◽  
Zhihua Zhang ◽  
Li Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Targeted Drug Delivery ◽  
Therapeutic Agents ◽  
Delivery Platform ◽  
Targeted Drug ◽  
Mitochondria Targeting

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13513-13522
Author(s):  
Zhichu Xiang ◽  
Gexuan Jiang ◽  
Di Fan ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Targeted Drug

Tumor-targeted drug carriers are becoming attractive for precise drug delivery in anti-tumor therapy.

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