Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13513-13522
Author(s):  
Zhichu Xiang ◽  
Gexuan Jiang ◽  
Di Fan ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Drug Carriers ◽  
Targeted Drug

Tumor-targeted drug carriers are becoming attractive for precise drug delivery in anti-tumor therapy.

Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications

2020 ◽  
Vol 20 (4) ◽  
pp. 271-287 ◽  
Author(s):  
Kuldeep Rajpoot
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Cancer Therapies ◽  
Medication Delivery ◽  
Lipid Nanocarriers ◽  
Targeted Drug ◽  
Drug Nanocarriers

Though modern available cancer therapies are effective, they possess major adverse effects, causing non-compliance to patients. Furthermore, the majority of the polymeric-based medication platforms are certainly not universally acceptable, due to their several restrictions. With this juxtaposition, lipid-based medication delivery systems have appeared as promising drug nanocarriers to replace the majority of the polymer-based products because they are in a position to reverse polymer as well as, drug-associated restrictions. Furthermore, the amalgamation of the basic principle of nanotechnology in designing lipid nanocarriers, which are the latest form of lipid carriers, has tremendous chemotherapeutic possibilities as tumor-targeted drug-delivery pertaining to tumor therapy. Apart from this, it is reported that nearly 40% of the modern medication entities are lipophilic. Moreover, research continues to be efficient in attaining a significant understanding of the absorption and bioavailability of the developed lipids systems.

A paclitaxel-conjugated adenovirus vector for targeted drug delivery for tumor therapy

Biomaterials ◽  
2012 ◽  
Vol 33 (1) ◽  
pp. 146-162 ◽  
Author(s):  
Lingling Shan ◽  
Sisi Cui ◽  
Changli Du ◽  
Shunan Wan ◽  
Zhiyu Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Adenovirus Vector ◽  
Targeted Drug

scholarly journals Mini Review: Nano-Technology based Drug Deliveries

2018 ◽  
Vol 8 (6) ◽  
pp. 268-271
Author(s):  
Kuilong Wang
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Targeted Drug Delivery ◽  
Research Work ◽  
Drug Carriers ◽  
Nano Technology ◽  
Treatment Conditions ◽  
Nanoparticle Formulation ◽  
Targeted Drug

Targeted drug delivery with nano-technology has been researched and identified as being efficient across many treatment conditions. This review assesses some of the existing research work and evidence practice in using nano-technology based drug carriers. Keywords: Nano-technology, drug delivery, nanoparticle formulation, nano-technology carriers, drug resistance

Folic Acid Functionalized Zirconium‐Based Metal–Organic Frameworks as Drug Carriers for Active Tumor‐Targeted Drug Delivery

2018 ◽  
Vol 24 (64) ◽  
pp. 17148-17154 ◽  
Author(s):  
Hong Dong ◽  
Gui‐Xin Yang ◽  
Xin Zhang ◽  
Xiang‐Bin Meng ◽  
Jing‐Li Sheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Metal Organic ◽  
Targeted Drug

scholarly journals The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series)

2017 ◽  
Vol 8 (1) ◽  
pp. 204589321775232 ◽  
Author(s):  
Jacob S. Brenner ◽  
Raisa Yu. Kiseleva ◽  
Patrick M. Glassman ◽  
Hamideh Parhiz ◽  
Colin F. Greineder ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Carriers ◽  
Pulmonary Vasculature ◽  
Pulmonary Endothelium ◽  
Targeted Interventions ◽  
Safety Parameters ◽  
Specific Affinity ◽  
Targeted Drug ◽  
High Doses

The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung transplant, and acute respiratory distress syndrome. Therapy for these diseases is quite limited, largely due to dose-limiting side effects of numerous drugs that have been trialed or approved. High doses of drugs targeting the pulmonary vasculature are needed due to the lack of specific affinity of therapeutic compounds to the vasculature. To overcome this problem, the field of targeted drug delivery aims to target drugs to the pulmonary endothelial cells, especially those in pathological regions. The field uses a variety of drug delivery systems (DDSs), ranging from nano-scale drug carriers, such as liposomes, to methods of conjugating drugs to affinity moieites, such as antibodies. These DDSs can deliver small molecule drugs, protein therapeutics, and imaging agents. Here we review targeted drug delivery to the pulmonary endothelium for the treatment of pulmonary diseases. Cautionary notes are made of the risk–benefit ratio and safety—parameters one should keep in mind when developing a translational therapeutic.

Role of size of drug delivery carriers for pulmonary and intravenous administration with emphasis on cancer therapeutics and lung-targeted drug delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (62) ◽  
pp. 32673-32689 ◽  
Author(s):  
Chetna Dhand ◽  
Molamma P. Prabhakaran ◽  
Roger W. Beuerman ◽  
R. Lakshminarayanan ◽  
Neeraj Dwivedi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Intravenous Administration ◽  
Targeted Drug Delivery ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Design Parameters ◽  
Targeted Drug

The design of a drug delivery system and the fabrication of efficient, successful, and targeted drug carriers are two separate issues that require slightly different design parameters.

scholarly journals A Review on Nanocarriers for Cancer Targeted Drug Delivery

2020 ◽  
Vol 63 (3) ◽  
pp. 239-246
Author(s):  
Fariha Lrfan ◽  
Tahir Lqbal ◽  
Nafisa Malik ◽  
Mohsin Ljaz
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Effective Drug ◽  
Targeted Drug

Nanoparticles in the drugs are useful for the treatment of cancer due to their unique properties and can act as drug carriers in different ways. Unlike the traditional chemotherapy, the entrance of nanotechnology enabled wide applications in treatment of cancer. Although nanoparticles provides safe and effective drug delivery systems but the factor of toxicity still limits the utilisation of several nanoparticles. The properties of nanodrug carriers are controllable by various factors. The use of nanoparticles in cancer therapy by drug delivery and their advantages as been reviewed.      

scholarly journals The Two Sweet Sides of Janus Lectin Drive Crosslinking of Liposomes to Cancer Cells and Material Uptake

Toxins ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 792
Author(s):  
Lina Siukstaite ◽  
Francesca Rosato ◽  
Anna Mitrovic ◽  
Peter Fritz Müller ◽  
Katharina Kraus ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Drug Carriers ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Tumor Recognition ◽  
Cancer Types ◽  
Targeted Drug ◽  
Extracellular Structures

A chimeric, bispecific Janus lectin has recently been engineered with different, rationally oriented recognition sites. It can bind simultaneously to sialylated and fucosylated glycoconjugates. Because of its multivalent architecture, this lectin reaches nanomolar avidities for sialic acid and fucose. The lectin was designed to detect hypersialylation—a dysregulation in physiological glycosylation patterns, which promotes the tumor growth and progression of several cancer types. In this study, the characteristic properties of this bispecific Janus lectin were investigated on human cells by flow cytometry and confocal microscopy in order to understand the fundamentals of its interactions. We evaluated its potential in targeted drug delivery, precisely leading to the cellular uptake of liposomal content in human epithelial cancer cells. We successfully demonstrated that Janus lectin mediates crosslinking of glyco-decorated giant unilamellar vesicles (GUVs) and H1299 lung epithelial cells. Strikingly, the Janus lectin induced the internalization of liposomal lipids and also of complete GUVs. Our findings serve as a solid proof of concept for lectin-mediated targeted drug delivery using glyco-decorated liposomes as possible drug carriers to cells of interest. The use of Janus lectin for tumor recognition certainly broadens the possibilities for engineering diverse tailor-made lectin constructs, specifically targeting extracellular structures of high significance in pathological conditions.

scholarly journals Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1717
Author(s):  
Yedi Herdiana ◽  
Nasrul Wathoni ◽  
Shaharum Shamsuddin ◽  
I Made Joni ◽  
Muchtaridi Muchtaridi
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Drug Carriers ◽  
Efficient Treatment ◽  
Targeted Drug

Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

Multifunctional NaYF4:Yb, Er@mSiO2@Fe3O4-PEG nanoparticles for UCL/MR bioimaging and magnetically targeted drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (5) ◽  
pp. 1839-1848 ◽  
Author(s):  
Bei Liu ◽  
Chunxia Li ◽  
Ping'an Ma ◽  
Yinyin Chen ◽  
Yuanxin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Tumor Therapy ◽  
Diagnostic Methods ◽  
Targeted Drug

The NaYF4:Yb, Er@mSiO2@Fe3O4-PEG nanoparticles combining dual-modal diagnostic methods and magnetically targeted anti-tumor therapy were investigated.

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