scholarly journals Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

2018 ◽  
Vol 9 (8) ◽  
pp. 2092-2097 ◽  
Author(s):  
Yao Sun ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Changhao Liu ◽  
Hua Zhu ◽  
...  
Keyword(s):  
Small Molecule ◽  
Near Infrared ◽  
Image Guided Surgery ◽  
Dual Function ◽  
Tumor Delineation ◽  
Guided Surgery ◽  
Image Guided

The first small-molecule based αvβ3-targeted NIR-II/PET dual-modal probesviabase-catalyzed thiol-addition chemistry were concisely assembled and evaluated.

scholarly journals Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Joy L. Kovar ◽  
Lael L. Cheung ◽  
Melanie A. Simpson ◽  
D. Michael Olive
Keyword(s):  
Small Molecule ◽  
Near Infrared ◽  
Image Guided Surgery ◽  
Tumor Delineation ◽  
Guided Surgery ◽  
Image Guided ◽  
Tumor Bearing ◽  
Tissue Contrast

Prostate cancer is the most frequently diagnosed cancer in men and often requires surgery. Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. IRDye 800CW was conjugated to YC-27 or an anti-PSMA antibody used for reference. Human 22Rv1, PC3M-LN4, and/or LNCaP prostate tumor cells were exposed to the labeled compounds.In vivotargeting and clearance properties were determined in tumor-bearing mice. Organs and tumors were excised and imaged to assess probe localization. YC-27 exhibited a dose dependent increase in signal upon binding. Binding specificity and internalization were visualized by microscopy.In vitroandin vivoblocking studies confirmed YC-27 specificity.In vivo, YC-27 showed good tumor delineation and tissue contrast at doses as low as 0.25 nmole. YC-27 was cleared via the kidneys but bound the proximal tubules of the renal cortex and epididymis. Since PSMA is also broadly expressed on the neovasculature of most tumors, we expect YC-27 will have clinical utility for image-guided surgery and tumor resections.

The Fluostick, a real hand-held system for near-infrared fluorescence image-guided surgery

2014 ◽  
Author(s):  
Paul Dorval ◽  
Norman Mangeret ◽  
Stephanie Guillermet ◽  
Christian Adrien Righini ◽  
Gabriele Barabino ◽  
...  
Keyword(s):  
Near Infrared ◽  
Image Guided Surgery ◽  
Fluorescence Image ◽  
Near Infrared Fluorescence ◽  
Guided Surgery ◽  
Image Guided ◽  
Real Hand

Intraoperative near-infrared image-guided surgery for peritoneal carcinomatosis in a preclinical experimental model

2010 ◽  
Vol 97 (5) ◽  
pp. 737-743 ◽  
Author(s):  
M. Keramidas ◽  
V. Josserand ◽  
C. A. Righini ◽  
C. Wenk ◽  
C. Faure ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Experimental Model ◽  
Near Infrared ◽  
Infrared Image ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Near-Infrared Illumination of Native Tissues for Image-Guided Surgery

2016 ◽  
Vol 59 (11) ◽  
pp. 5311-5323 ◽  
Author(s):  
Eric A. Owens ◽  
Hoon Hyun ◽  
Tyler L. Dost ◽  
Jeong Heon Lee ◽  
GwangLi Park ◽  
...  
Keyword(s):  
Near Infrared ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Image-Guided Surgery: Are We Getting the Most Out of Small-Molecule Prostate-Specific-Membrane-Antigen-Targeted Tracers?

2019 ◽  
Vol 31 (2) ◽  
pp. 375-395 ◽  
Author(s):  
Albertus Wijnand Hensbergen ◽  
Danny M. van Willigen ◽  
Florian van Beurden ◽  
Pim J. van Leeuwen ◽  
Tessa Buckle ◽  
...  
Keyword(s):  
Small Molecule ◽  
Image Guided Surgery ◽  
Prostate Specific Membrane Antigen ◽  
Guided Surgery ◽  
Image Guided ◽  
Specific Membrane

scholarly journals Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging

Small ◽  
2019 ◽  
Vol 15 (45) ◽  
pp. 1903382 ◽  
Author(s):  
Qing Zhang ◽  
Huijun Zhou ◽  
Hao Chen ◽  
Xiao Zhang ◽  
Shuqing He ◽  
...  
Keyword(s):  
Image Guided Surgery ◽  
Tumor Delineation ◽  
Guided Surgery ◽  
Image Guided ◽  
Bimodal Imaging ◽  
Hybrid Platform

scholarly journals Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

2017 ◽  
Vol 8 (5) ◽  
pp. 3489-3493 ◽  
Author(s):  
Yao Sun ◽  
Mingmin Ding ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Huaping Wu ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Small Molecule ◽  
Tumor Imaging ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Bright Emission

This work presents the establishment of novel bright-emission small-molecule NIR-II fluorophores forin vivotumor imaging and NIR-II image-guided sentinel lymph node surgery.

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