scholarly journals Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image‐Guided Surgery via NIR‐II Fluorescence and PET Bimodal Imaging

Small ◽  
2019 ◽  
Vol 15 (45) ◽  
pp. 1903382 ◽  
Author(s):  
Qing Zhang ◽  
Huijun Zhou ◽  
Hao Chen ◽  
Xiao Zhang ◽  
Shuqing He ◽  
...  
Keyword(s):  
Image Guided Surgery ◽  
Tumor Delineation ◽  
Guided Surgery ◽  
Image Guided ◽  
Bimodal Imaging ◽  
Hybrid Platform

scholarly journals Pharmacokinetic and Biodistribution Assessment of a Near Infrared-Labeled PSMA-Specific Small Molecule in Tumor-Bearing Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Joy L. Kovar ◽  
Lael L. Cheung ◽  
Melanie A. Simpson ◽  
D. Michael Olive
Keyword(s):  
Small Molecule ◽  
Near Infrared ◽  
Image Guided Surgery ◽  
Tumor Delineation ◽  
Guided Surgery ◽  
Image Guided ◽  
Tumor Bearing ◽  
Tissue Contrast

Prostate cancer is the most frequently diagnosed cancer in men and often requires surgery. Use of near infrared (NIR) technologies to perform image-guided surgery may improve accurate delineation of tumor margins. To facilitate preclinical testing of such outcomes, here we developed and characterized a PSMA-targeted small molecule, YC-27. IRDye 800CW was conjugated to YC-27 or an anti-PSMA antibody used for reference. Human 22Rv1, PC3M-LN4, and/or LNCaP prostate tumor cells were exposed to the labeled compounds.In vivotargeting and clearance properties were determined in tumor-bearing mice. Organs and tumors were excised and imaged to assess probe localization. YC-27 exhibited a dose dependent increase in signal upon binding. Binding specificity and internalization were visualized by microscopy.In vitroandin vivoblocking studies confirmed YC-27 specificity.In vivo, YC-27 showed good tumor delineation and tissue contrast at doses as low as 0.25 nmole. YC-27 was cleared via the kidneys but bound the proximal tubules of the renal cortex and epididymis. Since PSMA is also broadly expressed on the neovasculature of most tumors, we expect YC-27 will have clinical utility for image-guided surgery and tumor resections.

scholarly journals Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

2018 ◽  
Vol 9 (8) ◽  
pp. 2092-2097 ◽  
Author(s):  
Yao Sun ◽  
Xiaodong Zeng ◽  
Yuling Xiao ◽  
Changhao Liu ◽  
Hua Zhu ◽  
...  
Keyword(s):  
Small Molecule ◽  
Near Infrared ◽  
Image Guided Surgery ◽  
Dual Function ◽  
Tumor Delineation ◽  
Guided Surgery ◽  
Image Guided

The first small-molecule based αvβ3-targeted NIR-II/PET dual-modal probesviabase-catalyzed thiol-addition chemistry were concisely assembled and evaluated.

Three-Dimensional Localization: From Image-Guided Surgery to Information-Guided Therapy

Methods ◽  
2001 ◽  
Vol 25 (2) ◽  
pp. 186-200 ◽  
Author(s):  
Richard D. Bucholz ◽  
Kurt R. Smith ◽  
Keith A. Laycock ◽  
Leslie L. McDurmont
Keyword(s):  
Three Dimensional ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
Guided Therapy

scholarly journals Radiopharmaceutical and Eu3+ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiaojing Shi ◽  
Caiguang Cao ◽  
Zeyu Zhang ◽  
Jie Tian ◽  
Zhenhua Hu
Keyword(s):  
Fluorescent Probes ◽  
Signal Intensity ◽  
Tumor Imaging ◽  
Tumor Resection ◽  
Optical Signal ◽  
Gadolinium Oxide ◽  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided ◽  
The Impact

AbstractCerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it’s interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu3+ doped gadolinium oxide (Gd2O3:Eu) was synthesized and combined with radiopharmaceuticals to achieve a red-shifted optical spectrum with less tissue scattering and enhanced optical signal intensity in this study. The interaction between Gd2O3:Eu and radiopharmaceutical were investigated using 18F-fluorodeoxyglucose (18F-FDG). The ex vivo optical signal intensity of the mixture of Gd2O3:Eu and 18F-FDG reached 369 times as high as that of CLI using 18F-FDG alone. To achieve improved biocompatibility, the Gd2O3:Eu nanoparticles were then modified with polyvinyl alcohol (PVA), and the resulted nanoprobe PVA modified Gd2O3:Eu (Gd2O3:Eu@PVA) was applied in intraoperative tumor imaging. Compared with 18F-FDG alone, intraoperative administration of Gd2O3:Eu@PVA and 18F-FDG combination achieved a much higher tumor-to-normal tissue ratio (TNR, 10.24 ± 2.24 vs. 1.87 ± 0.73, P = 0.0030). The use of Gd2O3:Eu@PVA and 18F-FDG also assisted intraoperative detection of tumors that were omitted by preoperative positron emission tomography (PET) imaging. Further experiment of image-guided surgery demonstrated feasibility of image-guided tumor resection using Gd2O3:Eu@PVA and 18F-FDG. In summary, Gd2O3:Eu can achieve significantly optimized imaging property when combined with 18F-FDG in intraoperative tumor imaging and image-guided tumor resection surgery. It is expected that the development of the Gd2O3:Eu nanoparticle will promote investigation and application of novel nanoparticles that can interact with radiopharmaceuticals for improved imaging properties. This work highlighted the impact of the nanoprobe that can be excited by radiopharmaceuticals emitting CL, β, and γ radiation for precisely imaging of tumor and intraoperatively guide tumor resection.

Image‐guided surgery in otolaryngology: A review of current applications and future directions in head and neck surgery

Head & Neck ◽  
2021 ◽  
Author(s):  
Sarah Y. Bessen ◽  
Xiaotian Wu ◽  
Michael T. Sramek ◽  
Yuan Shi ◽  
David Pastel ◽  
...  
Keyword(s):  
Head And Neck ◽  
Neck Surgery ◽  
Head And Neck Surgery ◽  
Image Guided Surgery ◽  
Future Directions ◽  
Guided Surgery ◽  
Image Guided

scholarly journals Dual-mode optical imaging system for fluorescence image-guided surgery

2014 ◽  
Vol 39 (13) ◽  
pp. 3830 ◽  
Author(s):  
Nan Zhu ◽  
Suman Mondal ◽  
Shengkui Gao ◽  
Samuel Achilefua ◽  
Viktor Gruev ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Imaging System ◽  
Image Guided Surgery ◽  
Dual Mode ◽  
Fluorescence Image ◽  
Guided Surgery ◽  
Image Guided ◽  
Optical Imaging System

The Image-Guided Surgery ToolKit IGSTK: an open source C++ software toolkit

2007 ◽  
Author(s):  
Peng Cheng ◽  
Luis Ibanez ◽  
David Gobbi ◽  
Kevin Gary ◽  
Stephen Aylward ◽  
...  
Keyword(s):  
Open Source ◽  
Image Guided Surgery ◽  
Software Toolkit ◽  
Guided Surgery ◽  
Image Guided

Image-Guided Surgery

1999 ◽  
Vol 280 (6) ◽  
pp. 62-69 ◽  
Author(s):  
W. Eric L. Grimson ◽  
Ron Kikinis ◽  
Ferenc A. Jolesz ◽  
Peter McL. Black
Keyword(s):  
Image Guided Surgery ◽  
Guided Surgery ◽  
Image Guided
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