scholarly journals Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study

RSC Advances ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 4472-4477 ◽  
Author(s):  
Si Yao ◽  
Yunman Zheng ◽  
Lijun Jiang ◽  
Chen Xie ◽  
Fengshou Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Dna Photocleavage ◽  
Methylene Violet ◽  
Cell Study

A novel PDT photosensitizer which features great biomedical properties can be simply prepared.

scholarly journals Photochemistry and DNA photocleavage by a new unsupported dirhodium(II,II) complex

2013 ◽  
Vol 371 (1995) ◽  
pp. 20120128 ◽  
Author(s):  
Zhanyong Li ◽  
Scott J. Burya ◽  
Claudia Turro ◽  
Kim R. Dunbar
Keyword(s):  
Crystal Structure ◽  
Mass Spectrometry ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Photochemical Transformation ◽  
Ionization Mass ◽  
Dna Photocleavage ◽  
Metal Metal

The new complex [Rh 2 (phen) 2 (CH 3 CN) 6 ](BF 4 ) 4 ( 1 ) was synthesized and characterized in solution and its crystal structure was determined. Irradiation of 1 with visible light ( λ irr >590 nm) in water results in the release of two equatorial CH 3 CN ligands, CH 3 CN eq , as well as in the formation of mononuclear radical Rh(II) fragments stemming from the homolytic photocleavage of the metal–metal bond. The photoproducts, identified by electrospray ionization mass spectrometry, include [Rh(phen)(CH 3 CN)(OH)] + and [Rh(phen)(CH 3 CN)(H 2 O) 3 (BF 4 )] + . The quantum yield for the photochemical transformation of 1 in H 2 O exceeds unity ( Φ 550 nm =1.38) indicative of dark reactions following the initial photoprocess. DNA photocleavage was observed for 1 ( λ irr >590 nm), whereas the complex is unreactive in the dark. This feature makes 1 a promising photodynamic therapy agent that does not operate via the production of singlet oxygen, 1 O 2 .

New RuIIpincer complexes: synthesis, characterization and biological evaluation for photodynamic therapy

2016 ◽  
Vol 45 (45) ◽  
pp. 18333-18345 ◽  
Author(s):  
Leila Tabrizi ◽  
Hossein Chiniforoshan
Keyword(s):  
Photodynamic Therapy ◽  
Dna Binding ◽  
Biological Evaluation ◽  
Pincer Complexes ◽  
Dna Photocleavage ◽  
Ct Dna

The CT DNA binding, DNA photocleavage and photocytotoxicity of ruthenium(ii)–NCN pincer complexes were investigated.

scholarly journals Endoscopic filter fluorometer for emission detection of Protoporphyrin IX and its direct precursors in PDT and PDD

2020 ◽  
Vol 6 (3) ◽  
pp. 587-590 ◽  
Author(s):  
Axel Boese ◽  
Alexander Wagner ◽  
Michael Friebe ◽  
Uwe Bernd Liehr ◽  
Jakob Johann Wendler
Keyword(s):  
Photodynamic Therapy ◽  
Protoporphyrin Ix ◽  
Minimal Invasive ◽  
Imaging Systems ◽  
Optimal Time ◽  
Viable Option ◽  
Non Invasive ◽  
Emission Detection ◽  
Potential Option ◽  
Cell Study

AbstractPhotodynamic therapy (PDT) is a potential option for treatment of cancer since it can be performed non- invasive for superficial cancers or minimal-invasive with low traumatization. But PDT is intrinsically inefficient due to the complex accumulation of the photosensitizing drug inside the tumor and the processes of heme syntheses to create the needed cell killing components. To optimize the outcome of PDT and increase acceptance as viable option it is necessary to predict the optimal time for the start of the treatment based on measurable precursors. A former cell study proposed a new filter fluorometer in a complex and sensitive setup. In this work we now designed and tested a simplified system that can be used in combination with standard endoscopic imaging systems. This system will be used as base to prove viability of this approach for a future clinical study.

Water soluble cationic porphyrin TMPipEOPP-induced G-quadruplex and double-stranded DNA photocleavage and cell phototoxicity

RSC Advances ◽  
2016 ◽  
Vol 6 (16) ◽  
pp. 13080-13087 ◽  
Author(s):  
Li-Na Zhu ◽  
Shan Shi ◽  
Lin Yang ◽  
Min Zhang ◽  
Ke-Ke Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Dna Photocleavage ◽  
Cationic Porphyrin ◽  
Porphyrin Derivative ◽  
Double Stranded Dna ◽  
G Quadruplex ◽  
Human Telomere

A water soluble cationic porphyrin derivative TMPipEOPP can preferentially photocleave G-quadruplex in the presence of ​double-stranded DNA, thus might be used as a human telomere-targeted photosensitizer for tumor photodynamic therapy.

DNA Photocleavage and Binding Modes of Methylene Violet 3RAX and its Derivatives: Effect of Functional Groups

2017 ◽  
Vol 70 (7) ◽  
pp. 830 ◽  
Author(s):  
Ke Yang ◽  
Xiong Zhang ◽  
Fang Yang ◽  
Fengshou Wu ◽  
Xiulan Zhang ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Electrostatic Interactions ◽  
1H Nmr Spectroscopy ◽  
Binding Mode ◽  
Binding Modes ◽  
Oxygen Production ◽  
Groove Binding ◽  
Dna Photocleavage ◽  
Intercalative Mode ◽  
Methylene Violet

With 4′-amino-N,N-diethylaniline and aniline as starting materials, methylene violet 3RAX 1 and its derivatives 2–5 were synthesised. The five compounds were characterised by IR, UV-vis, and 1H NMR spectroscopy and mass spectrometry. The binding mode between the synthesised compounds and DNA were investigated. The results show that both compounds 1 and 5 bind to DNA by an intercalative mode, while compounds 2–4 interact with DNA through a mixed binding mode involving groove binding and electrostatic interactions. The photocleavage ability of the five compounds to DNA were calculated to be 38, 40, 30, 20, and 13 %, respectively, when their concentration was adjusted to 400 μM. The singlet oxygen production of compounds measured by the 1,3-diphenylisobenzofuran method was consistent with the trend of DNA photocleavage ability. The DNA studies suggest that the binding mode between methylene violet 3RAX and DNA, the ability of methylene violet 3RAX to generate singlet oxygen, and the DNA photocleavage activity could be adjusted through modification of the amino group on methylene violet 3RAX.

Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7875-7887 ◽  
Author(s):  
Ying Lan ◽  
Xiaohui Zhu ◽  
Ming Tang ◽  
Yihan Wu ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

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