Water soluble cationic porphyrin TMPipEOPP-induced G-quadruplex and double-stranded DNA photocleavage and cell phototoxicity

RSC Advances ◽  
2016 ◽  
Vol 6 (16) ◽  
pp. 13080-13087 ◽  
Author(s):  
Li-Na Zhu ◽  
Shan Shi ◽  
Lin Yang ◽  
Min Zhang ◽  
Ke-Ke Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Dna Photocleavage ◽  
Cationic Porphyrin ◽  
Porphyrin Derivative ◽  
Double Stranded Dna ◽  
G Quadruplex ◽  
Human Telomere

A water soluble cationic porphyrin derivative TMPipEOPP can preferentially photocleave G-quadruplex in the presence of ​double-stranded DNA, thus might be used as a human telomere-targeted photosensitizer for tumor photodynamic therapy.

A water-soluble cationic porphyrin showing pH-dependent G-quadruplex recognition specificity and DNA photocleavage activity

RSC Advances ◽  
2015 ◽  
Vol 5 (59) ◽  
pp. 47709-47717 ◽  
Author(s):  
Ting Zhao ◽  
Ya-Ling Wang ◽  
Li-Na Zhu ◽  
Yan-Fang Huo ◽  
Yong-Jian Wang ◽  
...  
Keyword(s):  
Water Soluble ◽  
Duplex Dna ◽  
Dna Photocleavage ◽  
Cationic Porphyrin ◽  
Recognition Specificity ◽  
G Quadruplex ◽  
Ph Dependent

A new water-soluble cationic porphyrin was synthesized. It shows pH-dependent G-quadruplex recognition specificity against duplex DNA, pH-dependent photocleavage activity towards duplex DNA and pH-dependent phototoxicity to cells.

scholarly journals Pressure Perturbation Studies of Noncanonical Viral Nucleic Acid Structures

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1173
Author(s):  
Judit Somkuti ◽  
Orsolya Réka Molnár ◽  
Anna Grád ◽  
László Smeller
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Pressure Perturbation ◽  
Viral Nucleic Acid ◽  
Cationic Porphyrin ◽  
G Quadruplex ◽  
Human Telomere ◽  
Temperature And Pressure ◽  
The Stability ◽  
Nucleic Acid Structures

G-quadruplexes are noncanonical structures formed by guanine-rich sequences of the genome. They are found in crucial loci of the human genome, they take part in the regulation of important processes like cell proliferation and cell death. Much less is known about the subjects of this work, the viral G-quadruplexes. We have chosen three potentially G-quadruplex-forming sequences of hepatitis B. We measured the stability and the thermodynamic parameters of these quadruplexes. We also investigated the potential stabilization of these G-quadruplexes by binding a special ligand that was originally developed for cancer therapy. Fluorescence and infrared spectroscopic measurements were performed over wide temperature and pressure ranges. Our experiments indicate the small unfolding volume change of all three oligos. We found a difference between the unfolding of the 2-quartet and the 3-quartet G-quadruplexes. All three G-quadruplexes were stabilized by TMPyP4, which is a cationic porphyrin developed for stabilizing the human telomere.

scholarly journals A New Cationic Porphyrin Derivative (TMPipEOPP) with Large Side Arm Substituents: A Highly Selective G-Quadruplex Optical Probe

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e35586 ◽  
Author(s):  
Li-Na Zhu ◽  
Shu-Juan Zhao ◽  
Bin Wu ◽  
Xiao-Zeng Li ◽  
De-Ming Kong
Keyword(s):  
Optical Probe ◽  
Cationic Porphyrin ◽  
Porphyrin Derivative ◽  
G Quadruplex ◽  
Large Side

Simple nanophotosensitizer fabrication using water-soluble chitosan for photodynamic therapy in gastrointestinal cancer cells

2017 ◽  
Vol 532 (1) ◽  
pp. 194-203 ◽  
Author(s):  
Young-IL Jeong ◽  
Byungyoul Cha ◽  
Hye Lim Lee ◽  
Yeon Hui Song ◽  
Yun Hye Jung ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Gastrointestinal Cancer ◽  
Water Soluble

scholarly journals Human telomere double G-quadruplex recognition by berberine-bisquinolinium imaging conjugates in vitro and in cells

2020 ◽  
Vol 158 ◽  
pp. 1299-1309
Author(s):  
Ting-Cong Liao ◽  
Tian-Zhu Ma ◽  
Suo-Bin Chen ◽  
Agostino Cilibrizzi ◽  
Meng-Jia Zhang ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Human Telomere ◽  
In Cells

Water-soluble dendritic polyaspartic porphyrins: potential photosensitizers for photodynamic therapy

2012 ◽  
Vol 36 (1) ◽  
pp. 28-31 ◽  
Author(s):  
Baoxiang Gao ◽  
Yueling Liu ◽  
Huijuan Yin ◽  
Yingxin Li ◽  
Qianqian Bai ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble
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