scholarly journals pH-responsive magnetic micelles gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 as a hydrophilic drug carrier

RSC Advances ◽  
2017 ◽  
Vol 7 (45) ◽  
pp. 28207-28212 ◽  
Author(s):  
Chao-Ming Su ◽  
Chen-Yu Huang ◽  
Yao-Li Chen ◽  
Tzong-Rong Ger
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Magnetic Targeting ◽  
Ph Responsive ◽  
Hydrophilic Drug

In the study, pH-selective magnetic targeting micelle, Gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 (GPDF), has been synthesized for controlled release of a hydrophilic insulin-promoting factor, nicotinamide.

A thermo- and pH-responsive poly(N-isopropylacrylamide)–Mn–ZnS nanocomposite for controlled release and real-time photoluminescence tracking of doxorubicin

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 50985-50992 ◽  
Author(s):  
Ruo-Mei Wang ◽  
Qian Liu ◽  
Yu Zhang ◽  
Zhangyong Hong ◽  
He-Fang Wang
Keyword(s):  
Controlled Release ◽  
Real Time ◽  
Drug Carrier ◽  
Ph Responsive ◽  
Smart Drug ◽  
Ph Controlled

A novel multifunctional poly(N-isopropylacrylamide)–Mn–ZnS (PMZS) nanocomposite was developed as a smart drug carrier for thermo- and pH-controlled release of doxorubicin (Dox) and real-time photoluminescence tracking of the released Dox.

Encapsulation of Imatinib in Targeted KIT-5 Nanoparticles for Reducing its Cardiotoxicity and Hepatotoxicity

2020 ◽  
Vol 20 (16) ◽  
pp. 1966-1980
Author(s):  
Jaleh Varshosaz ◽  
Saeedeh Fardshouraki ◽  
Mina Mirian ◽  
Leila Safaeian ◽  
Setareh Jandaghian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Side Effects ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Drug Carrier ◽  
Free Drug ◽  
Jurkat Cells ◽  
Targeted Nanoparticles ◽  
Inhibitor Drug ◽  
Histopathological Results

Background: Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the drug. Methods: KIT-5 nanoparticles were functionalized with 3-aminopropyltriethoxysilane and conjugated to rituximab as the targeting agent for the CD20 positive receptors of the B-cells. Then they were loaded with imatinib and their physical properties were characterized. The cell cytotoxicity of the nanoparticles was studied by MTT assay in Ramos (CD20 positive) and Jurkat cell lines (CD20 negative) and their cellular uptake was shown by fluorescence microscope. Wistar rats received an intraperitoneal injection of 50 mg/kg of the free drug or targeted nanoparticles for 21 days. Then the level of aspartate Aminotransferase (AST), alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH) were measured in serum of animals. The cardiotoxicity and hepatotoxicity of the drug were also studied by hematoxylin and eosin staining of the tissues. Results: The targeted nanoparticles of imatinib showed to be more cytotoxic to Ramos cells rather than Jurkat cells. The results of the biochemical analysis displayed a significant reduction in AST, ALT, ALP, and LDH levels in animals treated with targeted nanoparticles, compared to the free drug group. By comparison with the free imatinib, histopathological results represented less cardiotoxicity and hepatotoxicity in the animals, which received the drug through the current designed delivery system. Conclusion: The obtained results confirmed that the rituximab targeted KIT-5 nanoparticles are promising in the controlled release of imatinib and could decrease its cardiotoxicity and hepatotoxicity side effects.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

Tunable macroporous D-galactose based hydrogels for controlled release of a hydrophilic drug

2021 ◽  
Vol 150 ◽  
pp. 110409
Author(s):  
Shubhra Goel ◽  
Tejinder Kaur ◽  
Neetu Singh ◽  
Josemon Jacob
Keyword(s):  
Controlled Release ◽  
Hydrophilic Drug

scholarly journals Formulation and development of metformin-loaded microspheres using Khaya senegalensis (Meliaceae) gum as co-polymer

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Chukwuebuka H. Ozoude ◽  
Chukwuemeka P. Azubuike ◽  
Modupe O. Ologunagba ◽  
Sejoro S. Tonuewa ◽  
Cecilia I. Igwilo
Keyword(s):  
Controlled Release ◽  
Sodium Alginate ◽  
Release Kinetics ◽  
Drug Carrier ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Metformin Hydrochloride ◽  
Scanning Calorimetry ◽  
Khaya Senegalensis

Abstract Background Khaya gum is a bark exudate from Khaya senegalensis (Maliaecae) that has drug carrier potential. This study aimed to formulate and comparatively evaluate metformin-loaded microspheres using blends of khaya gum and sodium alginate. Khaya gum was extracted and subjected to preformulation studies using established protocols while three formulations (FA; FB and FC) of metformin (1% w/v)-loaded microspheres were prepared by the ionic gelation method using 5% zinc chloride solution as the cross-linker. The formulations contained 2% w/v blends of khaya gum and sodium alginate in the ratios of 2:3, 9:11, and 1:1, respectively. The microspheres were evaluated by scanning electron microscopy, Fourier transform-infrared spectroscopy, differential scanning calorimetry, entrapment efficiency, swelling index, and in vitro release studies. Results Yield of 28.48%, pH of 4.00 ± 0.05, moisture content (14.59% ± 0.50), and fair flow properties (Carr’s index 23.68 ± 1.91 and Hausner’s ratio 1.31 ± 0.03) of the khaya gum were obtained. FTIR analyses showed no significant interaction between pure metformin hydrochloride with excipients. Discrete spherical microspheres with sizes ranging from 1200 to 1420 μm were obtained. Drug entrapment efficiency of the microspheres ranged from 65.6 to 81.5%. The release of the drug from microspheres was sustained for the 9 h of the study as the cumulative release was 62% (FA), 73% (FB), and 80% (FC). The release kinetics followed Korsmeyer-Peppas model with super case-II transport mechanism. Conclusion Blends of Khaya senegalensis gum and sodium alginate are promising polymer combination for the preparation of controlled-release formulations. The blend of the khaya gum and sodium alginate produced microspheres with controlled release properties. However, the formulation containing 2:3 ratio of khaya gum and sodium alginate respectively produced microspheres with comparable controlled release profiles to the commercial brand metformin tablet.

Magnetic- and pH-responsive κ-carrageenan/chitosan complexes for controlled release of methotrexate anticancer drug

2017 ◽  
Vol 97 ◽  
pp. 209-217 ◽  
Author(s):  
Gholam Reza Mahdavinia ◽  
Amirabbas Mosallanezhad ◽  
Moslem Soleymani ◽  
Mohammad Sabzi
Keyword(s):  
Controlled Release ◽  
Anticancer Drug ◽  
Ph Responsive

Novel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release

2012 ◽  
Vol 89 (4) ◽  
pp. 1207-1214 ◽  
Author(s):  
Yunyan Bai ◽  
Zhe Zhang ◽  
Aiping Zhang ◽  
Li Chen ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Controlled Release ◽  
Glutamic Acid ◽  
Hydroxypropyl Cellulose ◽  
Oral Insulin ◽  
Ph Responsive

pH-Responsive Nanoscale Covalent Organic Polymers as a Biodegradable Drug Carrier for Combined Photodynamic Chemotherapy of Cancer

2018 ◽  
Vol 10 (17) ◽  
pp. 14475-14482 ◽  
Author(s):  
Hairong Wang ◽  
Wenwen Zhu ◽  
Jingjing Liu ◽  
Ziliang Dong ◽  
Zhuang Liu
Keyword(s):  
Drug Carrier ◽  
Organic Polymers ◽  
Ph Responsive
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