A thermo- and pH-responsive poly(N-isopropylacrylamide)–Mn–ZnS nanocomposite for controlled release and real-time photoluminescence tracking of doxorubicin

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 50985-50992 ◽  
Author(s):  
Ruo-Mei Wang ◽  
Qian Liu ◽  
Yu Zhang ◽  
Zhangyong Hong ◽  
He-Fang Wang
Keyword(s):  
Controlled Release ◽  
Real Time ◽  
Drug Carrier ◽  
Ph Responsive ◽  
Smart Drug ◽  
Ph Controlled

A novel multifunctional poly(N-isopropylacrylamide)–Mn–ZnS (PMZS) nanocomposite was developed as a smart drug carrier for thermo- and pH-controlled release of doxorubicin (Dox) and real-time photoluminescence tracking of the released Dox.

Cytotoxicity of pH-Responsive Dextrin Nanogels against Human Osteosarcoma 143B Cells

2014 ◽  
Vol 1060 ◽  
pp. 227-230
Author(s):  
Somkamon Manchun ◽  
Crispin R. Dass ◽  
Pornsak Sriamornsak
Keyword(s):  
Inhibition Efficiency ◽  
Treatment Time ◽  
Morphological Changes ◽  
Drug Carrier ◽  
Cross Linking ◽  
Dependent Manner ◽  
Ph Responsive ◽  
Human Osteosarcoma ◽  
Cell Inhibition ◽  
Smart Drug

To overcome major side-effects, that is, cardiotoxicity of doxorubicin (DOX), pH-responsive dextrin nanogels (DNGs) were developed for using as a smart drug carrier. DOX-loaded DNGs were fabricated by emulsion cross-linking technique using glyoxal as a cross-linking agent to form acid-sensitive, acetal bonds. The objective of this study was to investigate the cytotoxicity of DOX-loaded DNGs on the human osteosarcoma 143B cell line. The cytotoxicity assay results showed that DOX-loaded DNGs retained high cell inhibition efficiency in 143B cells in a concentration- and treatment time-dependent manner. The cytotoxicity decreased with increasing ratio of glyoxal to dextrin. Observation of 143B cells by light microscopy showed the morphological changes after treatment with DOX-loaded DNGs. These results suggested that DOX-loaded DNGs with pH-sensitive properties is promising for use as a drug delivery system for cancer therapy.

scholarly journals pH-responsive magnetic micelles gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 as a hydrophilic drug carrier

RSC Advances ◽  
2017 ◽  
Vol 7 (45) ◽  
pp. 28207-28212 ◽  
Author(s):  
Chao-Ming Su ◽  
Chen-Yu Huang ◽  
Yao-Li Chen ◽  
Tzong-Rong Ger
Keyword(s):  
Controlled Release ◽  
Drug Carrier ◽  
Magnetic Targeting ◽  
Ph Responsive ◽  
Hydrophilic Drug

In the study, pH-selective magnetic targeting micelle, Gelatin-g-poly(NIPAAm-co-DMAAm-co-UA)-g-dextran/Fe3O4 (GPDF), has been synthesized for controlled release of a hydrophilic insulin-promoting factor, nicotinamide.

Diazonaphthoquinone-based amphiphilic polymer assemblies for NIR/UV light- and pH-responsive controlled release

2018 ◽  
Vol 9 (4) ◽  
pp. 463-471 ◽  
Author(s):  
Qingwei Li ◽  
Ziquan Cao ◽  
Guojie Wang
Keyword(s):  
Controlled Release ◽  
Uv Light ◽  
Amphiphilic Polymer ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Responsive Polymer ◽  
Self Assembled ◽  
Stimuli Responsive Polymer ◽  
Ph Controlled

A multiple-stimuli-responsive polymer nanocarrier has been self-assembled for NIR/UV light- and pH-controlled cargo release.

Improved pH-Controlled Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide

2021 ◽  
Author(s):  
Abdelnour Alhourani ◽  
Jan-Lukas Førde ◽  
Lutz Eichacker ◽  
Lars Herfindal ◽  
Hanne Hagland
Keyword(s):  
Graphene Oxide ◽  
Controlled Release ◽  
Graphene Nanosheets ◽  
Drug Carrier ◽  
Chemical Vapor ◽  
Drug Carriers ◽  
Covalent Attachment ◽  
Cancer Drug ◽  
Delivery Options ◽  
Ph Controlled

Graphene-based drug carriers provide a promising addition to current cancer drug 8 delivery options. Increased accessibility of high-quality graphene made by plasma- enhanced chemical vapor deposition (PE-CVD) makes it an attractive material to re-visit in comparison to the widely studied graphene oxide (GO) in drug delivery. Here we show the potential of re-purposing the metabolic drug phenformin for cancer treatment in terms of stability, binding, and pH-controlled release. Using covalent attachment of polyethylene glycol (PEG) onto pristine (PE-CVD) graphene, we show that the PEG stabilized graphene nanosheets (PGNS) drug carrier is stable in aqueous solutions, exhibit a higher binding affinity towards phenformin than conventional GO. Moreover, we experimentally demonstrate an improved drug release in PGNS than GO in pH levels lower than physiological conditions comparable to an acidic tumor microenvironment.

Improved pH-Controlled Release of Phenformin from Low-Defect Graphene Compared to Graphene Oxide

2021 ◽  
Author(s):  
Abdelnour Alhourani ◽  
Jan-Lukas Førde ◽  
Lutz Eichacker ◽  
Lars Herfindal ◽  
Hanne Hagland
Keyword(s):  
Graphene Oxide ◽  
Controlled Release ◽  
Graphene Nanosheets ◽  
Drug Carrier ◽  
Chemical Vapor ◽  
Drug Carriers ◽  
Covalent Attachment ◽  
Cancer Drug ◽  
Delivery Options ◽  
Ph Controlled

Graphene-based drug carriers provide a promising addition to current cancer drug 8 delivery options. Increased accessibility of high-quality graphene made by plasma- enhanced chemical vapor deposition (PE-CVD) makes it an attractive material to re-visit in comparison to the widely studied graphene oxide (GO) in drug delivery. Here we show the potential of re-purposing the metabolic drug phenformin for cancer treatment in terms of stability, binding, and pH-controlled release. Using covalent attachment of polyethylene glycol (PEG) onto pristine (PE-CVD) graphene, we show that the PEG stabilized graphene nanosheets (PGNS) drug carrier is stable in aqueous solutions, exhibit a higher binding affinity towards phenformin than conventional GO. Moreover, we experimentally demonstrate an improved drug release in PGNS than GO in pH levels lower than physiological conditions comparable to an acidic tumor microenvironment.

Encapsulation of Imatinib in Targeted KIT-5 Nanoparticles for Reducing its Cardiotoxicity and Hepatotoxicity

2020 ◽  
Vol 20 (16) ◽  
pp. 1966-1980
Author(s):  
Jaleh Varshosaz ◽  
Saeedeh Fardshouraki ◽  
Mina Mirian ◽  
Leila Safaeian ◽  
Setareh Jandaghian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Side Effects ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Drug Carrier ◽  
Free Drug ◽  
Jurkat Cells ◽  
Targeted Nanoparticles ◽  
Inhibitor Drug ◽  
Histopathological Results

Background: Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the drug. Methods: KIT-5 nanoparticles were functionalized with 3-aminopropyltriethoxysilane and conjugated to rituximab as the targeting agent for the CD20 positive receptors of the B-cells. Then they were loaded with imatinib and their physical properties were characterized. The cell cytotoxicity of the nanoparticles was studied by MTT assay in Ramos (CD20 positive) and Jurkat cell lines (CD20 negative) and their cellular uptake was shown by fluorescence microscope. Wistar rats received an intraperitoneal injection of 50 mg/kg of the free drug or targeted nanoparticles for 21 days. Then the level of aspartate Aminotransferase (AST), alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH) were measured in serum of animals. The cardiotoxicity and hepatotoxicity of the drug were also studied by hematoxylin and eosin staining of the tissues. Results: The targeted nanoparticles of imatinib showed to be more cytotoxic to Ramos cells rather than Jurkat cells. The results of the biochemical analysis displayed a significant reduction in AST, ALT, ALP, and LDH levels in animals treated with targeted nanoparticles, compared to the free drug group. By comparison with the free imatinib, histopathological results represented less cardiotoxicity and hepatotoxicity in the animals, which received the drug through the current designed delivery system. Conclusion: The obtained results confirmed that the rituximab targeted KIT-5 nanoparticles are promising in the controlled release of imatinib and could decrease its cardiotoxicity and hepatotoxicity side effects.

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

scholarly journals Real‐Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue

2020 ◽  
Vol 59 (35) ◽  
pp. 15152-15156 ◽  
Author(s):  
Beatriz Lozano‐Torres ◽  
Juan F. Blandez ◽  
Irene Galiana ◽  
Alba García‐Fernández ◽  
María Alfonso ◽  
...  
Keyword(s):  
Controlled Release ◽  
Real Time ◽  
Cellular Senescence ◽  
Nile Blue ◽  
Fluorescent Dye ◽  
In Vivo Detection
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