scholarly journals Mononuclear Pd(ii) and Pt(ii) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction versus proven models from biological media

2018 ◽  
Vol 5 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Ana I. Matesanz ◽  
Eva Jimenez-Faraco ◽  
María C. Ruiz ◽  
Lucia M. Balsa ◽  
Carmen Navarro-Ranninger ◽  
...  
Keyword(s):  
Cancer Cells ◽  
High Selectivity ◽  
Biological Interaction ◽  
Biological Media ◽  
Thiosemicarbazone Complexes ◽  
Solution Behaviour ◽  
Interaction Versus

Pd(ii) and P(ii) thiosemicarbazone complexes with high selectivity towards cancer cells and a novel biological interaction profile.

Therapeutic Delivery of Polymeric Tadpole Nanostructures with High Selectivity to Triple Negative Breast Cancer Cells

2020 ◽  
Vol 21 (11) ◽  
pp. 4457-4468 ◽  
Author(s):  
Valentin A. Bobrin ◽  
Yanling Lin ◽  
Jianwei He ◽  
Yan Qi ◽  
Wenyi Gu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
High Selectivity ◽  
Triple Negative ◽  
Therapeutic Delivery

A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells

2018 ◽  
Vol 6 (16) ◽  
pp. 2413-2416 ◽  
Author(s):  
Mingxing Hu ◽  
Chao Yang ◽  
Yi Luo ◽  
Fan Chen ◽  
Fangfang Yang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
High Selectivity ◽  
Theranostic Agent ◽  
Anti Cancer

A novel hypoxia-specific and mitochondria-targeted theranostic agent,HMX-1, was reported with certified anti-cancer efficiencyin vitroandin vivo.

scholarly journals Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase II<i>α</i> and Activity against Breast Cancer Cells

2016 ◽  
Vol 06 (02) ◽  
pp. 146-154 ◽  
Author(s):  
Jennifer D. Conner ◽  
Wathsala Medawala ◽  
Madison T. Stephens ◽  
William H. Morris ◽  
Joseph E. Deweese ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Topoisomerase Ii ◽  
Thiosemicarbazone Complexes

scholarly journals RGD-modified dihydrolipoamide dehydrogenase conjugated to titanium dioxide nanoparticles –switchableintegrin-targeted photodynamic treatment of melanoma cells

RSC Advances ◽  
2018 ◽  
Vol 8 (17) ◽  
pp. 9112-9119 ◽  
Author(s):  
Avraham Dayan ◽  
Gideon Fleminger ◽  
Osnat Ashur-Fabian
Keyword(s):  
Titanium Dioxide ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
High Selectivity ◽  
Titanium Dioxide Nanoparticles ◽  
Melanoma Cells ◽  
Dihydrolipoamide Dehydrogenase ◽  
Photodynamic Treatment ◽  
Targeted Photodynamic Therapy

This work presents a UVA switchable integrin-targeted photodynamic therapy in melanoma, composed of an RGD-modified DLDH conjugated to TiO2nanoparticles, with high selectivity towards integrin-expressing cancer cells.

New copper(i) complexes selective for prostate cancer cells

2020 ◽  
Vol 49 (35) ◽  
pp. 12273-12286
Author(s):  
João Franco Machado ◽  
Diogo Sequeira ◽  
Fernanda Marques ◽  
M. Fátima M. Piedade ◽  
Maria J. Villa de Brito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
High Selectivity ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
New Family ◽  
Prostate Cells

Synthesis of a new family of Cu(i)–phosphane complexes with N,O-heteroaromatic ligands leads to the complexes showing impressive cytotoxicity against LNCap human prostate cancer cells allied to high selectivity than against RWPE non-tumoral prostate cells.

Fluorescence studies of the intra-cellular distribution of zinc bis(thiosemicarbazone) complexes in human cancer cells

2005 ◽  
pp. 845 ◽  
Author(s):  
Andrew R. Cowley ◽  
Jason Davis ◽  
Jonathan R. Dilworth ◽  
Paul S. Donnelly ◽  
Rachel Dobson ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cellular Distribution ◽  
Fluorescence Studies ◽  
Human Cancer Cells ◽  
Thiosemicarbazone Complexes

Anchored protease-activatable polymersomes for molecular diagnostics of metastatic cancer cells

2017 ◽  
Vol 5 (48) ◽  
pp. 9571-9578 ◽  
Author(s):  
Hyun-Ouk Kim ◽  
Jong-Woo Lim ◽  
Jihye Choi ◽  
Hwunjae Lee ◽  
Hye Young Son ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Cancer Cells ◽  
Molecular Diagnostics ◽  
High Selectivity ◽  
Metastatic Cancer ◽  
Metastatic Cancer Cells

We have designed unique protease-activatable polymersomes (PeptiSomes) forin situquantitative analysis with high selectivity towards MT1-MMP.

scholarly journals Plasma‐activated medium induces apoptosis in chemotherapy‐resistant ovarian cancer cells: High selectivity and synergy with carboplatin

2021 ◽  
Author(s):  
Milad Rasouli ◽  
Hassan Mehdian ◽  
Kamal Hajisharifi ◽  
Elaheh Amini ◽  
Kostya (Ken) Ostrikov ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
High Selectivity ◽  
Ovarian Cancer Cells

scholarly journals Screening for Selective Anticancer Activity of 65 Extracts of Plants Collected in Western Andalusia, Spain

Plants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2193
Author(s):  
José Manuel Calderón-Montaño ◽  
Sara María Martínez-Sánchez ◽  
Víctor Jiménez-González ◽  
Estefanía Burgos-Morón ◽  
Emilio Guillén-Mancina ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
High Selectivity ◽  
Survival Rates ◽  
Selectivity Index ◽  
Lung Cancer Cells ◽  
Taxus Baccata ◽  
Selective Toxicity ◽  
Tetraclinis Articulata ◽  
Pancratium Maritimum

Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of patients diagnosed with metastatic cancers. Since plants are an important source of anticancer drugs, we have screened 65 extracts from 45 plants collected in several areas of Western Andalusia (Spain) for cytotoxic activity on lung cancer cells versus lung normal cells. An extract from the leaves of Tetraclinis articulata (Vahl) Mast. (Cupressaceae) showed a marked cytotoxicity (IC50 = 0.37 ± 0.03 μg/mL) and selectivity (selectivity index = 378.3) against the lung cancer cells; cisplatin, 5-fluorouracil, and an extract from the leaves of Taxus baccata L. (Taxaceae) were less cytotoxic and selective. Extracts from Cascabela thevetia (L.) Lippold (Apocynaceae), Frangula alnus Mill. (Rhamnaceae), Iberis ciliata subsp. contracta (Pers.) Moreno (Brassicaceae), Juniperus macrocarpa Sm (Cupressaceae), and Pancratium maritimum L. (Amaryllidaceae) also showed selective cytotoxicity (selectivity index > 10). Active extracts were also tested against a panel of cancer cell lines from a variety tissues. The plants identified in this work are potential sources of natural compounds with selective toxicity towards cancer cells.

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