scholarly journals Cu(II) Propionyl-Thiazole Thiosemicarbazone Complexes: Crystal Structure, Inhibition of Human Topoisomerase IIα, and Activity against Breast Cancer Cells

2018 ◽  
Vol 08 (02) ◽  
pp. 30-46 ◽  
Author(s):  
Edward C. Lisic ◽  
Victoria G. Rand ◽  
Lana Ngo ◽  
Patrick Kent ◽  
Jeffrey Rice ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Crystal Structure ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Topoisomerase Iiα ◽  
Thiosemicarbazone Complexes

Synthesis and photodynamic activities of a new metronidazole-appended porphyrin and its Zn(II) complex

2015 ◽  
Vol 19 (10) ◽  
pp. 1107-1113 ◽  
Author(s):  
Qiong Yu ◽  
Wei-Xia Xu ◽  
Ya-Hong Yao ◽  
Zeng-Qi Zhang ◽  
Shu Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Crystal Structure ◽  
Oxygen Atom ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Porphyrin Ring ◽  
H Nmr ◽  
Pyramidal Geometry ◽  
Photodynamic Activity ◽  
Square Pyramidal Geometry

One novel porphyrin 5,10,15-tris(phenyl)-20-[4-(2-(2-methyl-5-nitro-imidazolyl)ethoxyl)phenyl] porphyrin and its zinc(II) metalloporphyrin were synthesized and characterized by IR, UV-vis, 1H NMR, MS and elemental analysis. The single crystal structure of zinc(II) porphyrin shows that the Zn(II) ion is coordinated with four nitrogen atoms of porphyrin ring and one oxygen atom of ethanol from axial, forming a five-coordinated square pyramidal geometry. Their cytotoxicity and photodynamic activity against breast cancer cells were studied. The results indicate that both of the porphyrins display high phototoxicity to the breast cancer cells with the negligible dark toxicity. In addition, the photodynamic activity of zinc(II) porphyrin was obviously higher than that of the free porphyrin.

scholarly journals Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase II<i>α</i> and Activity against Breast Cancer Cells

2016 ◽  
Vol 06 (02) ◽  
pp. 146-154 ◽  
Author(s):  
Jennifer D. Conner ◽  
Wathsala Medawala ◽  
Madison T. Stephens ◽  
William H. Morris ◽  
Joseph E. Deweese ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Topoisomerase Ii ◽  
Thiosemicarbazone Complexes

Crystal structure of epidoxorubicin–formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells

1999 ◽  
Vol 55 (9) ◽  
pp. 1516-1523 ◽  
Author(s):  
Elaine R. Podell ◽  
Daniel J. Harrington ◽  
Dylan J. Taatjes ◽  
Tad H. Koch
Keyword(s):  
Breast Cancer ◽  
Crystal Structure ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Covalent Attachment ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
In Cells ◽  
Covalently Bound

Epidoxorubicin and daunorubicin are proposed to be cytotoxic to tumor cells by catalyzing production of formaldehyde through redox cycling and using the formaldehyde for covalent attachment to DNA at G bases. The crystal structure of epidoxorubicin covalently bound to a d(CGCGCG) oligomer was determined to 1.6 Å resolution. The structure reveals slightly distorted B-form DNA bearing two molecules of epidoxorubicin symmetrically intercalated at the termini, with each covalently attached from its N3′ to N2 of a G base via a CH2 group from the formaldehyde. The structure is analogous to daunorubicin covalently bound to d(CGCGCG) determined previously, except for additional hydrogen bonding from the epimeric O4′ to O2 of a C base. The role of drug–DNA covalent bonding in cells was investigated with synthetic epidoxorubicin–formaldehyde conjugate (Epidoxoform) and synthetic daunorubicin–formaldehyde conjugate (Daunoform). Uptake and location of drug fluorophore in doxorubicin-resistant human breast-cancer cells (MCF-7/ADR cells) was observed by fluorescence microscopy and flow cytometry. The fluorophore of Daunoform appeared more rapidly in cells and was released more rapidly from cells than the fluorophore of Epidoxoform over a 3 h exposure period. The fluorophore appeared predominantly in the nucleus of cells treated with both conjugates. The difference in uptake is explained in terms of the slower rate of hydrolysis of Epidoxoform to the species reactive with DNA and a proposed slower release from DNA based upon the crystal structures.

Adenovirus-mediated human topoisomerase IIα gene transfer increases the sensitivity of etoposide-resistant human and mouse breast cancer cells

2005 ◽  
Vol 44 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Takeshi Asano ◽  
Eugenie S. Kleinerman ◽  
Leonard A. Zwelling ◽  
Zhichao Zhou ◽  
Yoshitaka Fukunaga
Keyword(s):  
Breast Cancer ◽  
Gene Transfer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Topoisomerase Iiα ◽  
Mouse Breast Cancer ◽  
Human And Mouse

scholarly journals Copper(ii) thiosemicarbazone complexes induce marked ROS accumulation and promote nrf2-mediated antioxidant response in highly resistant breast cancer cells

2017 ◽  
Vol 46 (12) ◽  
pp. 3833-3847 ◽  
Author(s):  
Angela Sîrbu ◽  
Oleg Palamarciuc ◽  
Maria V. Babak ◽  
Jia Min Lim ◽  
Kateryna Ohui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Mode Of Action ◽  
Breast Cancer Cells ◽  
Antioxidant Response ◽  
Water Soluble ◽  
Ros Accumulation ◽  
Thiosemicarbazone Complexes

The synthesis, characterisation and mode of action of water-soluble copper(ii)–TSC complexes are reported.

scholarly journals The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells

2009 ◽  
Vol 69 (3) ◽  
pp. 948-957 ◽  
Author(s):  
V. Ashutosh Rao ◽  
Sarah R. Klein ◽  
Keli K. Agama ◽  
Eriko Toyoda ◽  
Noritaka Adachi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Selective Inhibition ◽  
Iron Chelator ◽  
Topoisomerase Iiα
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