New copper(i) complexes selective for prostate cancer cells

2020 ◽  
Vol 49 (35) ◽  
pp. 12273-12286
Author(s):  
João Franco Machado ◽  
Diogo Sequeira ◽  
Fernanda Marques ◽  
M. Fátima M. Piedade ◽  
Maria J. Villa de Brito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
High Selectivity ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
New Family ◽  
Prostate Cells

Synthesis of a new family of Cu(i)–phosphane complexes with N,O-heteroaromatic ligands leads to the complexes showing impressive cytotoxicity against LNCap human prostate cancer cells allied to high selectivity than against RWPE non-tumoral prostate cells.

Osteoblast-derived factors increased metastatic potential in human prostate cancer cells

2016 ◽  
Author(s):  
Terese Karlsson ◽  
Reshma Sundar ◽  
Anders Widmark ◽  
Marene Landstrom ◽  
Emma Persson
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Metastatic Potential ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Anticancer Activity of Methyl Gallate in RC-58T/h/SA#4 Primary Human Prostate Cancer Cells

2014 ◽  
Vol 43 (3) ◽  
pp. 367-373 ◽  
Author(s):  
Soon Jae Kwon ◽  
Ju Hye Lee ◽  
Jae Yong Kim ◽  
Kwang Deog Moon ◽  
Sung Tae Yee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Methyl Gallate ◽  
Prostate Cancer Cells

scholarly journals Distinct roles for the RNA-binding protein Staufen1 in prostate cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kristen A. Marcellus ◽  
Tara E. Crawford Parks ◽  
Shekoufeh Almasi ◽  
Bernard J. Jasmin
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Rna Binding ◽  
Prostate Cancer Cell ◽  
Rna Binding Protein ◽  
Migration And Invasion ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Prostate Cells

Abstract Background Prostate cancer is one of the most common malignant cancers with the second highest global rate of mortality in men. During the early stages of disease progression, tumour growth is local and androgen-dependent. Despite treatment, a large percentage of patients develop androgen-independent prostate cancer, which often results in metastases, a leading cause of mortality in these patients. Our previous work on the RNA-binding protein Staufen1 demonstrated its novel role in cancer biology, and in particular rhabdomyosarcoma tumorigenesis. To build upon this work, we have focused on the role of Staufen1 in other forms of cancer and describe here the novel and differential roles of Staufen1 in prostate cancer. Methods Using a cell-based approach, three independent prostate cancer cell lines with different characteristics were used to evaluate the expression of Staufen1 in human prostate cancer relative to control prostate cells. The functional impact of Staufen1 on several key oncogenic features of prostate cancer cells including proliferation, apoptosis, migration and invasion were systematically investigated. Results We show that Staufen1 levels are increased in all human prostate cancer cells examined in comparison to normal prostate epithelial cells. Furthermore, Staufen1 differentially regulates growth, migration, and invasion in the various prostate cancer cells assessed. In LNCaP prostate cancer cells, Staufen1 regulates cell proliferation through mTOR activation. Conversely, Staufen1 regulates migration and invasion of the highly invasive, bone metastatic-derived, PC3 prostate cells via the activation of focal adhesion kinase. Conclusions Collectively, these results show that Staufen1 has a direct impact in prostate cancer development and further demonstrate that its functions vary amongst the prostate cancer cell types. Accordingly, Staufen1 represents a novel target for the development of much-needed therapeutic strategies for prostate cancer.

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