Governing the DNA-binding mode of styryl dyes by the length of their alkyl substituents – from intercalation to major groove binding

2018 ◽  
Vol 16 (4) ◽  
pp. 545-554 ◽  
Author(s):  
Daria V. Berdnikova ◽  
Nikolai I. Sosnin ◽  
Olga A. Fedorova ◽  
Heiko Ihmels
Keyword(s):  
Dna Binding ◽  
Binding Mode ◽  
Major Groove ◽  
Groove Binding ◽  
Styryl Dyes

The length of alkyl substituents governs the DNA binding mode of mono- and bis-chromophoric styryl dyes.

scholarly journals Novel DNA Bis-Intercalator XR5944 as a Potent Anticancer Drug—Design and Mechanism of Action

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4132
Author(s):  
Adam J. Buric ◽  
Jonathan Dickerhoff ◽  
Danzhou Yang
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Mechanism Of Action ◽  
Binding Mode ◽  
Mechanistic Study ◽  
Major Groove ◽  
Transcription Inhibition ◽  
Groove Binding ◽  
Targeted Agent ◽  
Anticancer Compound

This review is dedicated to Professor William A. Denny’s discovery of XR5944 (also known as MLN944). XR5944 is a DNA-targeted agent with exceptionally potent antitumor activity and a novel DNA binding mode, bis-intercalation and major groove binding, as well as a novel mechanism of action, transcription inhibition. This novel anticancer compound represents a remarkable accomplishment resulting from two decades of drug discovery by Professor Denny and coworkers. Here, we review our work on the structural study of the DNA binding mode of XR5944 and mechanistic study of XR5944 action.

scholarly journals Dimeric and trimeric derivatives of the azinomycin B chromophore show enhanced DNA binding

2017 ◽  
Vol 15 (21) ◽  
pp. 4522-4526 ◽  
Author(s):  
Milena Balazy ◽  
Alejandra Fausto ◽  
Christina Voskanian ◽  
Bianca Chavez ◽  
Harmanpreet Panesar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Major Groove ◽  
Groove Binding ◽  
Azinomycin B ◽  
Derivatives Of

Compound1d(Kapp= 2.4 × 107M−1), a derivative of the azinomycin B chromophore, strongly associates with DNA by intercalation and major groove binding.

From Intercalation to Groove Binding: Switching the DNA-Binding Mode of Isostructural Transition-Metal Complexes

2014 ◽  
Vol 20 (11) ◽  
pp. 3089-3096 ◽  
Author(s):  
Haslina Ahmad ◽  
Ashley Wragg ◽  
Will Cullen ◽  
Claire Wombwell ◽  
Anthony J. H. M. Meijer ◽  
...  
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Binding Mode ◽  
Groove Binding

Synthesis, Characterization, DNA-Binding Study of C15H12O4N2 and its Lanthanide Complexes

2013 ◽  
Vol 749 ◽  
pp. 516-520
Author(s):  
Chao Chao Song ◽  
Xiang Rong Liu ◽  
Shun Sheng Zhao ◽  
Jun Wang ◽  
Jing Wen Ren ◽  
...  
Keyword(s):  
Dna Binding ◽  
Ir Spectroscopy ◽  
Elemental Analysis ◽  
Lanthanide Complexes ◽  
Binding Mode ◽  
Binding Study ◽  
Groove Binding ◽  
Groove Binding Mode

A new series complexes of Ln nitrate with H2L, where Ln stands for La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Yb, and H2L is 2-carboxybenzaldehyde- (4-hydroxy) benzoylhydrazone, were synthesized. Elemental analysis and IR spectroscopy were used to characterize and found that the complexes were Ln (HL)2(NO3)·4EtOH·4H2O type. The binding mode of complexes with CTDNA was investigated by UV-Vis titration and emission titration, suggesting that the complexes bind with CTDNA in a non-covalent groove binding mode.

DNA Binding Mode of Transition Metal Complexes, A Relationship to Tumor Cell Toxicity

2014 ◽  
Vol 21 (26) ◽  
pp. 3081-3094 ◽  
Author(s):  
M. Ashfaq ◽  
T. Najam ◽  
S.S.A. Shah ◽  
M.M. Ahmad ◽  
S. Shaheen ◽  
...  
Keyword(s):  
Dna Binding ◽  
Transition Metal ◽  
Tumor Cell ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Binding Mode ◽  
Cell Toxicity

Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay

2007 ◽  
Vol 17 (4) ◽  
pp. 1013-1017 ◽  
Author(s):  
Ruel E. McKnight ◽  
Aaron B. Gleason ◽  
James A. Keyes ◽  
Sadia Sahabi
Keyword(s):  
Dna Binding ◽  
Topoisomerase I ◽  
Binding Mode ◽  
Dna Unwinding ◽  
Binding Agents ◽  
Dna Binding Agents

scholarly journals Denaturation of dsDNA Induced by Specific Major Groove Binding of Cadmium Ion to Thymine

ACS Omega ◽  
2017 ◽  
Vol 2 (11) ◽  
pp. 8490-8494 ◽  
Author(s):  
Haiyang Gao ◽  
Zhi Zhu ◽  
Xiankai Jiang ◽  
Jun Guo ◽  
Bo Song ◽  
...  
Keyword(s):  
Major Groove ◽  
Groove Binding ◽  
Cadmium Ion
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