One-pot synthesis of α,β-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts

2017 ◽  
Vol 15 (12) ◽  
pp. 2551-2561 ◽  
Author(s):  
Veeramanoharan Ashokkumar ◽  
Ayyanar Siva
Keyword(s):  
Good Yield ◽  
Bond Formation ◽  
Direct Access ◽  
Domino Reaction ◽  
One Pot ◽  
New Approach ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Epoxy Ketones

A proline based metal free organocatalysts developed by new approach for the synthesis of epoxide derivatives through domino reaction. This domino reaction allows the direct access to epoxide from various alkene and aldehyde through C–H functionalization and C–C/C–O bond formation. The catalytic efficiencies of organocatalysts were also determined by domino reaction with very good yield (up to 95 %) and ee's (up to 99 %).

A one pot, metal-free, three-component domino sequence for the synthesis of furans: an efficient C–O and C–N bond formation approach

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 39563-39567 ◽  
Author(s):  
Pengfeng Guo ◽  
Changcheng Wang ◽  
Ya Chen ◽  
Caijun Ou ◽  
Hangqi Jiang ◽  
...  
Keyword(s):  
Aromatic Amine ◽  
Bond Formation ◽  
Domino Reaction ◽  
Aliphatic Acid ◽  
One Pot ◽  
Furan Derivatives ◽  
Dicarbonyl Compounds ◽  
Metal Free

A novel one pot, metal-free, three-component domino reaction for the formation of furan derivatives has been developed from 3-phenylpropiolaldehyde, 1,3-dicarbonyl compounds and aromatic amine or aliphatic acid.

ChemInform Abstract: Metal-Free One-Pot Synthesis of 1,3-Diazaheterocyclic Compounds via I2-Mediated Oxidative C-N Bond Formation.

ChemInform ◽  
2015 ◽  
Vol 46 (48) ◽  
pp. no-no
Author(s):  
Xianhai Tian ◽  
Lina Song ◽  
Ertong Li ◽  
Qiang Wang ◽  
Wenquan Yu ◽  
...  
Keyword(s):  
Bond Formation ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C–N bond formation

RSC Advances ◽  
2015 ◽  
Vol 5 (76) ◽  
pp. 62194-62201 ◽  
Author(s):  
Xianhai Tian ◽  
Lina Song ◽  
Ertong Li ◽  
Qiang Wang ◽  
Wenquan Yu ◽  
...  
Keyword(s):  
Bond Formation ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

A variety of 1,3-diazaheterocyclic compounds, including quinazolinones, benzimidazoles, and cyclic amidines, were readily synthesized through this metal-free one-pot annulation reaction.

A transition metal-free approach towards synthesis of β-carboline tethered 1,3,4-oxadiazoles via oxidative C–O bond formation

2019 ◽  
Vol 43 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Dharmender Singh ◽  
Sandip Kumar Tiwari ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

An efficient protocol has been developed for one-pot synthesis of biologically interesting β-carboline substituted 1,3,4-oxadiazoles via an I2-assisted oxidative C–O bond formation strategy.

Synthesis of pyrazolo[1,5-c]quinazoline derivatives through the copper-catalyzed domino reaction of o-alkenyl aromatic isocyanides with diazo compounds

2020 ◽  
Vol 56 (55) ◽  
pp. 7665-7668 ◽  
Author(s):  
Lu Liu ◽  
Lei Li ◽  
Shukuan Mao ◽  
Xin Wang ◽  
Ming-Dong Zhou ◽  
...  
Keyword(s):  
Diazo Compounds ◽  
Domino Reaction ◽  
Reaction Conditions ◽  
One Pot ◽  
One Pot Synthesis ◽  
Quinazoline Derivatives

Various o-alkenyl aromatic isocyanides were prepared from readily available reactants for their double annulation with diazo compounds for a one-pot synthesis of pyrazolo[1,5-c]quinazolines under mild reaction conditions.

One-pot synthesis of bio-based polycarbonates from dimethyl carbonate and isosorbide under metal-free condition

2020 ◽  
Vol 22 (14) ◽  
pp. 4550-4560
Author(s):  
Wenjuan Fang ◽  
Zhencai Zhang ◽  
Zifeng Yang ◽  
Yaqin Zhang ◽  
Fei Xu ◽  
...  
Keyword(s):  
Dimethyl Carbonate ◽  
One Pot ◽  
Free Condition ◽  
Metal Free ◽  
One Pot Synthesis ◽  
Synthetic Strategy

A synthetic strategy for bio-based polycarbonate was developed via one-pot polymerization of renewable monomer isosorbide and dimethyl carbonate using eco-friendly organo-catalysts.

ChemInform Abstract: I2Promoted Domino Oxidative Cyclization for One-Pot Synthesis of 2-Acylbenzothiazoles via Metal-Free sp3C-H Functionalization.

ChemInform ◽  
2012 ◽  
Vol 43 (52) ◽  
pp. no-no
Author(s):  
Yan-Ping Zhu ◽  
Mi Lian ◽  
Feng-Cheng Jia ◽  
Mei-Cai Liu ◽  
Jing-Jing Yuan ◽  
...  
Keyword(s):  
Oxidative Cyclization ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

Promiscuous lipase catalyzed a new P-C bond formation: Green and efficient protocol for one-pot synthesis of α-aminophosphonates

2017 ◽  
Vol 28 (6) ◽  
pp. e21408 ◽  
Author(s):  
Samia Guezane-Lakoud ◽  
Martial Toffano ◽  
Louisa Aribi-Zouioueche
Keyword(s):  
Bond Formation ◽  
One Pot ◽  
One Pot Synthesis
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