ChemInform Abstract: I2-Mediated Oxidative C-N Bond Formation for Metal-Free One-Pot Synthesis of Di-, Tri-, and Tetrasubstituted Pyrazoles from α,β-Unsaturated Aldehydes/Ketones and Hydrazines.
A variety of 1,3-diazaheterocyclic compounds, including quinazolinones, benzimidazoles, and cyclic amidines, were readily synthesized through this metal-free one-pot annulation reaction.
A proline based metal free organocatalysts developed by new approach for the synthesis of epoxide derivatives through domino reaction. This domino reaction allows the direct access to epoxide from various alkene and aldehyde through C–H functionalization and C–C/C–O bond formation. The catalytic efficiencies of organocatalysts were also determined by domino reaction with very good yield (up to 95 %) and ee's (up to 99 %).
An efficient protocol has been developed for one-pot synthesis of biologically interesting β-carboline substituted 1,3,4-oxadiazoles via an I2-assisted oxidative C–O bond formation strategy.
A synthetic strategy for bio-based polycarbonate was developed via one-pot polymerization of renewable monomer isosorbide and dimethyl carbonate using eco-friendly organo-catalysts.