A revisit to the Gattermann reaction: interesting synthesis of nitrogen heterocyclic aromatic halides and their fluorescence properties

2017 ◽  
Vol 41 (20) ◽  
pp. 12225-12230 ◽  
Author(s):  
Juan Li ◽  
Ning Wang ◽  
Wen-Tao Liu ◽  
Hong-Lin Ding ◽  
Yue An ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Fluorescence Sensor ◽  
Fluorescence Properties ◽  
Electrophilic Substitution Reaction ◽  
One Pot ◽  
Highly Efficient ◽  
Nitrogen Heterocyclic

The Gattermann reaction and an electrophilic substitution reaction, which were conducted in a one-pot reaction, are reported, and four aromatic dihalides of similar structure were obtained. 2-Chloro-5-(3-chloro-4-methoxy-phenyl)-1,3,4-thiadiazole was applied as a highly efficient fluorescence sensor for the detection of TNP.

Ruthenium-catalyzed efficient routes to oxindole derivatives

2009 ◽  
Vol 87 (9) ◽  
pp. 1213-1217 ◽  
Author(s):  
Khalil Tabatabaeian ◽  
Manouchehr Mamaghani ◽  
Nosratollah Mahmoodi ◽  
Alireza Khorshidi
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Electrophilic Substitution Reaction ◽  
Reaction Conditions ◽  
One Pot

Ruthenium-catalyzed preparation of oxindoles from one-pot trimerization of indoles under oxidative conditions and from electrophilic substitution reaction of indoles with isatins or isatin-derived imines under very mild reaction conditions is reported.

scholarly journals Facile synthesis of bis(indolyl)methanes using iron(III) phosphate

2012 ◽  
Vol 77 (9) ◽  
pp. 1157-1163 ◽  
Author(s):  
Kargar Behbahani ◽  
Masoumeh Sasani
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Catalytic Amount ◽  
Reusable Catalyst ◽  
Electrophilic Substitution Reaction ◽  
Facile Synthesis

A new, convenient and high yielding procedure for the preparation of bis(indolyl)methanes in glycerol by electrophilic substitution reaction of indole with aldehydes in the presence of catalytic amount of FePO4 (5.0 mol%) as a highly stable and reusable catalyst is described.

ChemInform Abstract: Electrophilic Substitution Reaction and a Novel [1,3] Rearrangement of 4-Lithio-5-p-toluenesulfonyloxypyrazoles.

ChemInform ◽  
2010 ◽  
Vol 30 (16) ◽  
pp. no-no
Author(s):  
Dong Ju Jeon ◽  
Jung No Lee ◽  
Kyu Chul Lee ◽  
Hyoung Rae Kim ◽  
Kyukwan Zong ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Electrophilic Substitution Reaction

Nucleophilic Cyclization/Electrophilic Substitution of (2,2-Dialkoxyethyl)ureas: Highly Regioselective Access to Novel 4-(Het)arylimidazolidinones and Benzo[d][1,3]diazepinones

Synthesis ◽  
2020 ◽  
Vol 52 (21) ◽  
pp. 3263-3271
Author(s):  
Andrey V. Smolobochkin ◽  
Almir S. Gazizov ◽  
Nazerke K. Otegen ◽  
Julia K. Voronina ◽  
Anna G. Strelnik ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Biologically Active ◽  
Electrophilic Substitution Reaction ◽  
Reaction Sequence ◽  
Active Compounds ◽  
Acid Catalyzed ◽  
High Yields ◽  
Nucleophilic Cyclization ◽  
Mechanism Of The Reaction

Imidazolidin-2-one and 1,3-benzodiazepin-2-one scaffolds are structural motifs of many biologically active compounds. Herein, we report a highly regioselective acid-catalyzed intramolecular nucleophilic cyclization/intermolecular electrophilic substitution reaction sequence of (2,2-dialkoxyethyl)ureas. The reaction benefits from readily available starting materials, a simple workup procedure, moderate to high yields of target compounds, and provides a convenient entry to previously unknown 4-(het)arylimidazolidinones and 5-(het)arylbenzodiazepinones. The proposed mechanism of the reaction is also discussed.

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