Zeolite catalyzed electrophilic substitution reaction of indoles with aldehydes: synthesis of bis(indolyl)methanes

2004 ◽  
Vol 5 (7) ◽  
pp. 371-375 ◽  
Author(s):  
M Karthik ◽  
A.K Tripathi ◽  
N.M Gupta ◽  
M Palanichamy ◽  
V Murugesan
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Electrophilic Substitution Reaction

scholarly journals Facile synthesis of bis(indolyl)methanes using iron(III) phosphate

2012 ◽  
Vol 77 (9) ◽  
pp. 1157-1163 ◽  
Author(s):  
Kargar Behbahani ◽  
Masoumeh Sasani
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Catalytic Amount ◽  
Reusable Catalyst ◽  
Electrophilic Substitution Reaction ◽  
Facile Synthesis

A new, convenient and high yielding procedure for the preparation of bis(indolyl)methanes in glycerol by electrophilic substitution reaction of indole with aldehydes in the presence of catalytic amount of FePO4 (5.0 mol%) as a highly stable and reusable catalyst is described.

ChemInform Abstract: Electrophilic Substitution Reaction and a Novel [1,3] Rearrangement of 4-Lithio-5-p-toluenesulfonyloxypyrazoles.

ChemInform ◽  
2010 ◽  
Vol 30 (16) ◽  
pp. no-no
Author(s):  
Dong Ju Jeon ◽  
Jung No Lee ◽  
Kyu Chul Lee ◽  
Hyoung Rae Kim ◽  
Kyukwan Zong ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Electrophilic Substitution Reaction

Nucleophilic Cyclization/Electrophilic Substitution of (2,2-Dialkoxyethyl)ureas: Highly Regioselective Access to Novel 4-(Het)arylimidazolidinones and Benzo[d][1,3]diazepinones

Synthesis ◽  
2020 ◽  
Vol 52 (21) ◽  
pp. 3263-3271
Author(s):  
Andrey V. Smolobochkin ◽  
Almir S. Gazizov ◽  
Nazerke K. Otegen ◽  
Julia K. Voronina ◽  
Anna G. Strelnik ◽  
...  
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Biologically Active ◽  
Electrophilic Substitution Reaction ◽  
Reaction Sequence ◽  
Active Compounds ◽  
Acid Catalyzed ◽  
High Yields ◽  
Nucleophilic Cyclization ◽  
Mechanism Of The Reaction

Imidazolidin-2-one and 1,3-benzodiazepin-2-one scaffolds are structural motifs of many biologically active compounds. Herein, we report a highly regioselective acid-catalyzed intramolecular nucleophilic cyclization/intermolecular electrophilic substitution reaction sequence of (2,2-dialkoxyethyl)ureas. The reaction benefits from readily available starting materials, a simple workup procedure, moderate to high yields of target compounds, and provides a convenient entry to previously unknown 4-(het)arylimidazolidinones and 5-(het)arylbenzodiazepinones. The proposed mechanism of the reaction is also discussed.

VCl3 Catalysed Efficient Synthesis of Bis(indolyl)methanes

2005 ◽  
Vol 2005 (4) ◽  
pp. 222-223 ◽  
Author(s):  
Bavanthula Rajitha ◽  
Penthala Narsimha Reddy ◽  
Buridapad Sunil Kumar ◽  
Neeladri Sreenivasulu ◽  
Yerram Reddy Thirupathi Reddy
Keyword(s):  
Substitution Reaction ◽  
Electrophilic Substitution ◽  
Room Temperature ◽  
Aromatic Aldehydes ◽  
Electrophilic Substitution Reaction ◽  
Efficient Synthesis

VCl3 is found to be an efficient catalysts for the electrophilic substitution reaction of indoles with aromatic aldehydes in dichloromethane to afford the corresponding bis(indolyl)methanes in excellent yields at room temperature.

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