nucleophilic cyclization Latest Research Papers

Thiol “Click” Chromene Ring Opening and Subsequent Cascade Nucleophilic Cyclization NIR Fluorescence Imaging Reveal High Levels of Thiol in Drug-Resistant Cells

Analytical Chemistry ◽

10.1021/acs.analchem.0c03362 ◽

2020 ◽

Vol 92 (24) ◽

pp. 15936-15942

Author(s):

Kaiqing Ma ◽

Lingling Zhao ◽

Yongkang Yue ◽

Fangjun Huo ◽

Jianbin Chao ◽

...

Keyword(s):

Fluorescence Imaging ◽

Ring Opening ◽

Drug Resistant ◽

Nir Fluorescence ◽

Nucleophilic Cyclization ◽

Chromene Ring ◽

Resistant Cells

Download Full-text

Nucleophilic Cyclization/Electrophilic Substitution of (2,2-Dialkoxyethyl)ureas: Highly Regioselective Access to Novel 4-(Het)arylimidazolidinones and Benzo[d][1,3]diazepinones

Synthesis ◽

10.1055/s-0040-1707864 ◽

2020 ◽

Vol 52 (21) ◽

pp. 3263-3271

Author(s):

Andrey V. Smolobochkin ◽

Almir S. Gazizov ◽

Nazerke K. Otegen ◽

Julia K. Voronina ◽

Anna G. Strelnik ◽

...

Keyword(s):

Substitution Reaction ◽

Electrophilic Substitution ◽

Biologically Active ◽

Electrophilic Substitution Reaction ◽

Reaction Sequence ◽

Active Compounds ◽

Acid Catalyzed ◽

High Yields ◽

Nucleophilic Cyclization ◽

Mechanism Of The Reaction

Imidazolidin-2-one and 1,3-benzodiazepin-2-one scaffolds are structural motifs of many biologically active compounds. Herein, we report a highly regioselective acid-catalyzed intramolecular nucleophilic cyclization/intermolecular electrophilic substitution reaction sequence of (2,2-dialkoxyethyl)ureas. The reaction benefits from readily available starting materials, a simple workup procedure, moderate to high yields of target compounds, and provides a convenient entry to previously unknown 4-(het)arylimidazolidinones and 5-(het)arylbenzodiazepinones. The proposed mechanism of the reaction is also discussed.

Download Full-text

Ligand-Free Pd-Catalyzed Synthesis of 3-Allylbenzofurans by Merging Decarboxylative Allylation and Nucleophilic Cyclization

The Journal of Organic Chemistry ◽

10.1021/acs.joc.0c00375 ◽

2020 ◽

Vol 85 (11) ◽

pp. 7036-7044 ◽

Cited By ~ 4

Author(s):

Jie Zhang ◽

Jia-Yin Wang ◽

Min-Hua Huang ◽

Wen-Juan Hao ◽

Xing-Chao Tu ◽

...

Keyword(s):

Ligand Free ◽

Decarboxylative Allylation ◽

Nucleophilic Cyclization

Download Full-text

Synthesis of saturated nitrogen heterocycles by Strecker reaction – nucleophilic cyclization

Tetrahedron Letters ◽

10.1016/j.tetlet.2020.151645 ◽

2020 ◽

Vol 61 (12) ◽

pp. 151645

Author(s):

Oleksandr O. Grygorenko

Keyword(s):

Nitrogen Heterocycles ◽

Strecker Reaction ◽

Nucleophilic Cyclization

Download Full-text

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic addition of non-nucleophilic alkyls to alkynes

Chemical Communications ◽

10.1039/d0cc04636a ◽

2020 ◽

Vol 56 (78) ◽

pp. 11621-11624

Author(s):

Yanbin Zhang ◽

Ruiwen Jin ◽

Guangxing Pan ◽

Hao Guo

Keyword(s):

Nucleophilic Addition ◽

Nucleophilic Cyclization

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic cyclization of alkynes using non-nucleophilic alkyls as the nucleophile is reported.

Download Full-text

Berichtigung: Total Synthesis of (−)‐Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade

Angewandte Chemie ◽

10.1002/ange.201906637 ◽

2019 ◽

Vol 131 (31) ◽

pp. 10505-10505

Author(s):

Lei Zhang ◽

Ye Zhang ◽

Wenting Li ◽

Xiangbing Qi

Keyword(s):

Total Synthesis ◽

Nucleophilic Cyclization

Download Full-text

Corrigendum: Total Synthesis of (−)‐Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade

Angewandte Chemie International Edition ◽

10.1002/anie.201906637 ◽

2019 ◽

Vol 58 (31) ◽

pp. 10397-10397

Author(s):

Lei Zhang ◽

Ye Zhang ◽

Wenting Li ◽

Xiangbing Qi

Keyword(s):

Total Synthesis ◽

Nucleophilic Cyclization

Download Full-text

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

Journal of the American Chemical Society ◽

10.1021/jacs.9b04711 ◽

2019 ◽

Vol 141 (24) ◽

pp. 9527-9532 ◽

Cited By ~ 72

Author(s):

Miaomiao Tian ◽

Dachang Bai ◽

Guangfan Zheng ◽

Junbiao Chang ◽

Xingwei Li

Keyword(s):

Asymmetric Synthesis ◽

Axially Chiral ◽

Nucleophilic Cyclization

Download Full-text

Rhodium(III)-Catalyzed Oxidative Allylic C–H Indolylation via Nucleophilic Cyclization

Organic Letters ◽

10.1021/acs.orglett.9b01553 ◽

2019 ◽

Vol 21 (12) ◽

pp. 4662-4666 ◽

Cited By ~ 9

Author(s):

Jiaqiong Sun ◽

Kuan Wang ◽

Peiyuan Wang ◽

Guangfan Zheng ◽

Xingwei Li

Keyword(s):

Nucleophilic Cyclization

Download Full-text

Unexpected intramolecular nucleophilic cyclization of ureidoacetamide: A novel route towards the synthesis of 2,4,5-trisubsituted oxazoles

Tetrahedron Letters ◽

10.1016/j.tetlet.2019.05.028 ◽

2019 ◽

Vol 60 (26) ◽

pp. 1691-1695 ◽

Cited By ~ 3

Author(s):

Jianhui Liu ◽

Yawen Dong ◽

Guanglan Li ◽

Xiangting Min ◽

Mustafa Hussain

Keyword(s):

Nucleophilic Cyclization

Download Full-text

nucleophilic cyclization
Recently Published Documents

TOTAL DOCUMENTS

H-INDEX

Thiol “Click” Chromene Ring Opening and Subsequent Cascade Nucleophilic Cyclization NIR Fluorescence Imaging Reveal High Levels of Thiol in Drug-Resistant Cells

Nucleophilic Cyclization/Electrophilic Substitution of (2,2-Dialkoxyethyl)ureas: Highly Regioselective Access to Novel 4-(Het)arylimidazolidinones and Benzo[d][1,3]diazepinones

Ligand-Free Pd-Catalyzed Synthesis of 3-Allylbenzofurans by Merging Decarboxylative Allylation and Nucleophilic Cyclization

Synthesis of saturated nitrogen heterocycles by Strecker reaction – nucleophilic cyclization

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic addition of non-nucleophilic alkyls to alkynes

Berichtigung: Total Synthesis of (−)‐Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade

Corrigendum: Total Synthesis of (−)‐Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

Rhodium(III)-Catalyzed Oxidative Allylic C–H Indolylation via Nucleophilic Cyclization

Unexpected intramolecular nucleophilic cyclization of ureidoacetamide: A novel route towards the synthesis of 2,4,5-trisubsituted oxazoles

Export Citation Format

nucleophilic cyclizationRecently Published Documents

TOTAL DOCUMENTS

H-INDEX

Thiol “Click” Chromene Ring Opening and Subsequent Cascade Nucleophilic Cyclization NIR Fluorescence Imaging Reveal High Levels of Thiol in Drug-Resistant Cells

Nucleophilic Cyclization/Electrophilic Substitution of (2,2-Dialkoxyethyl)ureas: Highly Regioselective Access to Novel 4-(Het)arylimidazolidinones and Benzo[d][1,3]diazepinones

Ligand-Free Pd-Catalyzed Synthesis of 3-Allylbenzofurans by Merging Decarboxylative Allylation and Nucleophilic Cyclization

Synthesis of saturated nitrogen heterocycles by Strecker reaction – nucleophilic cyclization

Light-enabled, AlCl3-catalyzed regioselective intramolecular nucleophilic addition of non-nucleophilic alkyls to alkynes

Berichtigung: Total Synthesis of (−)‐Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade

Corrigendum: Total Synthesis of (−)‐Alstofolinine A through a Furan Oxidation/Rearrangement and Indole Nucleophilic Cyclization Cascade

Rh(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls by Merging C–H Activation and Nucleophilic Cyclization

Rhodium(III)-Catalyzed Oxidative Allylic C–H Indolylation via Nucleophilic Cyclization

Unexpected intramolecular nucleophilic cyclization of ureidoacetamide: A novel route towards the synthesis of 2,4,5-trisubsituted oxazoles

nucleophilic cyclization
Recently Published Documents