Chemo-photothermal therapy of cancer cells using gold nanorod-cored stimuli-responsive triblock copolymer

2017 ◽  
Vol 41 (21) ◽  
pp. 12777-12788 ◽  
Author(s):  
Mojtaba Abbasian ◽  
Farideh Mahmoodzadeh ◽  
Roya Salehi ◽  
Ahmad Amirshaghaghi
Keyword(s):  
Cancer Treatment ◽  
Cancer Cells ◽  
Treatment Option ◽  
Photothermal Therapy ◽  
Triblock Copolymer ◽  
Gold Nanorod ◽  
Stimuli Responsive

The combination of photothermal therapy and chemotherapy, when carefully planned, has been shown to be an effective cancer treatment option clinically and preclinically.

scholarly journals Engineered Zn(II)-Dipicolylamine-Gold Nanorod Provides Effective Prostate Cancer Treatment by Combining siRNA Delivery and Photothermal Therapy

Theranostics ◽  
2017 ◽  
Vol 7 (17) ◽  
pp. 4240-4254 ◽  
Author(s):  
Kyung Hyun Min ◽  
Young-Hwa Kim ◽  
Zhantong Wang ◽  
Jihoon Kim ◽  
Jee Seon Kim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Sirna Delivery ◽  
Gold Nanorod ◽  
Prostate Cancer Treatment

scholarly journals Magnetic tri-bead microrobot assisted near-infrared triggered combined photothermal and chemotherapy of cancer cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoxia Song ◽  
Zhi Chen ◽  
Xue Zhang ◽  
Junfeng Xiong ◽  
Teng Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Stimuli Responsive ◽  
Lung Cancer Cell ◽  
Precise Movement ◽  
Photothermal Property

AbstractMagnetic micro/nanorobots attracted much attention in biomedical fields because of their precise movement, manipulation, and targeting abilities. However, there is a lack of research on intelligent micro/nanorobots with stimuli-responsive drug delivery mechanisms for cancer therapy. To address this issue, we developed a type of strong covalently bound tri-bead drug delivery microrobots with NIR photothermal response azobenzene molecules attached to their carboxylic surface groups. The tri-bead microrobots are magnetic and showed good cytocompatibility even when their concentration is up to 200 µg/mL. In vitro photothermal experiments demonstrated fast NIR-responsive photothermal property; the microrobots were heated to 50 °C in 4 min, which triggered a significant increase in drug release. Motion control of the microrobots inside a microchannel demonstrated the feasibility of targeted therapy on tumor cells. Finally, experiments with lung cancer cells demonstrated the effectiveness of targeted chemo-photothermal therapy and were validated by cell viability assays. These results indicated that tri-bead microrobots have excellent potential for targeted chemo-photothermal therapy for lung cancer cell treatment.

CORMs loaded nanoplatform for the single NIR light-activated bioimaging, gas therapy, and photothermal therapy in vitro

2021 ◽  
Author(s):  
Shihao Pei ◽  
Jia-Bei Li ◽  
Zhuo Wang ◽  
Yao Xie ◽  
Jiabo Chen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Cancer Treatment ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Nir Light ◽  
Potential Alternative

Carbon monoxide (CO) can cause mitochondrial dysfunction, inducing apoptosis of cancer cells which sheds light on a potential alternative for cancer treatment. However, the existing CO-based compounds are inherently limited...

Combinational Chemotherapy and Photothermal Therapy Using a Gold Nanorod Platform for Cancer Treatment

2020 ◽  
Vol 37 (8) ◽  
pp. 2000099
Author(s):  
Nutan Shukla ◽  
Baljinder Singh ◽  
Ho‐Joong Kim ◽  
Myoung‐Hwan Park ◽  
Kibeom Kim
Keyword(s):  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Gold Nanorod

scholarly journals Poly-amino acids coated gold nanorod and doxorubicin for synergistic photodynamic therapy and chemotherapy in ovarian cancer cells

2019 ◽  
Vol 39 (12) ◽  
Author(s):  
JinYing Liu ◽  
Wei Ma ◽  
Wei Kou ◽  
Lina Shang ◽  
Rui Huang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Malignant Tumors ◽  
Gold Nanorod ◽  
Cell Group ◽  
Ovarian Cancer Cells ◽  
Ros Generation ◽  
Burst Release

Abstract In this work, we have successfully designed and formulated a doxorubicin-loaded polypeptide-based multilayer assembled gold nanorod (DH-GNR). We have hypothesized that near-infrared (NIR) laser irradiation of DH-GNR will combine the benefits of chemotherapy and photothermal therapy. The GNR was surface functionalized with poly-glutamic acid (PGA) and poly-l-Lysine (PLL) with a final layer of hyaluronic acid (HA) that could also serve as a targeting ligand toward the overexpressed CD44 receptors in ovarian cancer cells. The zigzag ζ potential of nanoparticle is a proof of successful assembly of alternative polymers on the GNR surface. NIR irradiation exhibited a burst release of drug in pH 7.4 and pH 5.0 buffer conditions. The combination of doxorubicin (DOX)-based chemotherapy and GNR-based photothermal therapy exhibited a synergistic effect in killing the SKOV3 cancer cells. DH-GNR(+NIR) induced a 82.5% apoptosis (combined early and late apoptosis) compared with only 35.2 and 38.5% for DOX or DH-GNR(−NIR) treated cell group. Results clearly suggest that the excessive reactive oxygen species (ROS) generation in DH-GNR (+NIR) might be responsible for the cell apoptosis and cell death. The promising anticancer effect of DH-GNR will be of great potential in the treatment of ovarian cancers and worth further development for treating other malignant tumors.

scholarly journals Photothermal therapy of single cancer cells mediated by naturally created gold nanorod clusters

2017 ◽  
Vol 25 (13) ◽  
pp. 15093 ◽  
Author(s):  
Zhimin Chen ◽  
Haihua Fan ◽  
Jinxiang Li ◽  
Shaolong Tie ◽  
Sheng Lan
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Gold Nanorod ◽  
Single Cancer

scholarly journals Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment

2021 ◽  
Vol 8 ◽  
Author(s):  
Fadak Howaili ◽  
Ezgi Özliseli ◽  
Berrin Küçüktürkmen ◽  
Seyyede Mahboubeh Razavi ◽  
Majid Sadeghizadeh ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Drug Carrier ◽  
Drug Loading ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Cytotoxicity Studies

Nanogels (Ng) are crosslinked polymer-based hydrogel nanoparticles considered to be next-generation drug delivery systems due to their superior properties, including high drug loading capacity, low toxicity, and stimuli responsiveness. In this study, dually thermo-pH-responsive plasmonic nanogel (AuNP@Ng) was synthesized by grafting poly (N-isopropyl acrylamide) (PNIPAM) to chitosan (CS) in the presence of a chemical crosslinker to serve as a drug carrier system. The nanogel was further incorporated with gold nanoparticles (AuNP) to provide simultaneous drug delivery and photothermal therapy (PTT). Curcumin's (Cur) low water solubility and low bioavailability are the biggest obstacles to effective use of curcumin for anticancer therapy, and these obstacles can be overcome by utilizing an efficient delivery system. Therefore, curcumin was chosen as a model drug to be loaded into the nanogel for enhancing the anticancer efficiency, and further, its therapeutic efficiency was enhanced by PTT of the formulated AuNP@Ng. Thorough characterization of Ng based on CS and PNIPAM was conducted to confirm successful synthesis. Furthermore, photothermal properties and swelling ratio of fabricated nanoparticles were evaluated. Morphology and size measurements of nanogel were determined by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). Nanogel was found to have a hydrodynamic size of ~167 nm and exhibited sustained release of curcumin up to 72 h with dual thermo-pH responsive drug release behavior, as examined under different temperature and pH conditions. Cytocompatibility of plasmonic nanogel was evaluated on MDA-MB-231 human breast cancer and non-tumorigenic MCF 10A cell lines, and the findings indicated the nanogel formulation to be cytocompatible. Nanoparticle uptake studies showed high internalization of nanoparticles in cancer cells when compared with non-tumorigenic cells and confocal microscopy further demonstrated that AuNP@Ng were internalized into the MDA-MB-231 cancer cells via endosomal route. In vitro cytotoxicity studies revealed dose-dependent and time-dependent drug delivery of curcumin loaded AuNP@Ng/Cur. Furthermore, the developed nanoparticles showed an improved chemotherapy efficacy when irradiated with near-infrared (NIR) laser (808 nm) in vitro. This work revealed that synthesized plasmonic nanogel loaded with curcumin (AuNP@Ng/Cur) can act as stimuli-responsive nanocarriers, having potential for dual therapy i.e., delivery of hydrophobic drug and photothermal therapy.

Se@SiO2–FA–CuS nanocomposites for targeted delivery of DOX and nano selenium in synergistic combination of chemo-photothermal therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 2866-2875 ◽  
Author(s):  
Yeying Wang ◽  
Xijian Liu ◽  
Guoying Deng ◽  
Jian Sun ◽  
Haikuan Yuan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Stimuli Responsive ◽  
Delivery Vehicle ◽  
Drug Delivery Vehicle ◽  
Synergistic Combination

A tumor-targeted and multi-stimuli-responsive drug delivery vehicle (Se@SiO2–FA–CuS/DOX) was fabricated for combined PTT with chemotherapy of DOX and Se in cancer treatment.

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