scholarly journals Novel cell-penetrating-amyloid peptide conjugates preferentially kill cancer cells

MedChemComm ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 121-130 ◽  
Author(s):  
John R. Veloria ◽  
Luxi Chen ◽  
Lin Li ◽  
Gail A. M. Breen ◽  
Jiyong Lee ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Diseases ◽  
Amyloid Peptide ◽  
Toxic Effects ◽  
Peptide Conjugates ◽  
Amyloid A ◽  
Cell Penetrating

The goal of this study was to develop a peptide which could use the toxic effects of amyloid, a substance which is the hallmark of over 25 known human diseases, to selectively kill cancer cells.

scholarly journals Delivering aminopyridine ligands into cancer cells through conjugation to the cell-penetrating peptide BP16

2016 ◽  
Vol 14 (17) ◽  
pp. 4061-4070 ◽  
Author(s):  
M. Soler ◽  
M. González-Bártulos ◽  
E. Figueras ◽  
A. Massaguer ◽  
L. Feliu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Peptide Conjugates ◽  
Cell Penetrating ◽  
High Cytotoxicity

Peptide conjugates incorporating a red-ox active aminopyridine ligand bound to the cell-penetrating peptide BP16 display high cytotoxicity.

18F-Labeled phosphopeptide-cell-penetrating peptide dimers with enhanced cell uptake properties in human cancer cells

2012 ◽  
Vol 39 (8) ◽  
pp. 1202-1212 ◽  
Author(s):  
Susan Richter ◽  
Vincent Bouvet ◽  
Melinda Wuest ◽  
Ralf Bergmann ◽  
Joerg Steinbach ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cell Uptake ◽  
Cell Penetrating Peptide ◽  
Human Cancer Cells ◽  
Cell Penetrating

scholarly journals Evaluation of cell penetrating peptide coated Mn:ZnS nanoparticles for paclitaxel delivery to cancer cells

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
N. Sanoj Rejinold ◽  
Yunho Han ◽  
Jisang Yoo ◽  
Hae Yong Seok ◽  
Ji Ho Park ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Novel “ruthenium cyclopentadienyl”–peptide conjugate complexes against human FGFR(+) breast cancer

2020 ◽  
Vol 49 (18) ◽  
pp. 5974-5987
Author(s):  
João Franco Machado ◽  
Miguel Machuqueiro ◽  
Fernanda Marques ◽  
M. Paula Robalo ◽  
M. Fátima M. Piedade ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Evaluation ◽  
Peptide Conjugates ◽  
Half Sandwich

Synthesis of the first half-sandwich ruthenium(ii)-cyclopentadienyl peptide conjugates and their biological evaluation against human FGFR(+) and FGFR(−) breast cancer cells.

scholarly journals Targeting EGFR Overexpression at the Surface of Colorectal Cancer Cells by Exploiting Amidated BODIPY‐Peptide Conjugates

2020 ◽  
Vol 96 (3) ◽  
pp. 581-595
Author(s):  
Tyrslai M. Williams ◽  
Zehua Zhou ◽  
Sitanshu S. Singh ◽  
Martha Sibrian‐Vazquez ◽  
Seetharama D. Jois ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Peptide Conjugates ◽  
Colorectal Cancer Cells

An enzyme-assisted self-delivery system of lonidamine–peptide conjugates for selectively killing cancer cells

2019 ◽  
Vol 55 (98) ◽  
pp. 14852-14855 ◽  
Author(s):  
Can Wu ◽  
Jing Liu ◽  
Xuan Tang ◽  
Ziran Zhai ◽  
Keming Xu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Delivery System ◽  
Peptide Conjugates ◽  
Self Assembling

A self-delivery system consisting of lonidamine and a self-assembling peptide was designed for the selective killing of phosphatase-overexpressing cancer cells.

Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosis

APOPTOSIS ◽  
2009 ◽  
Vol 14 (11) ◽  
pp. 1352-1365 ◽  
Author(s):  
Sonia Aroui ◽  
Souhir Brahim ◽  
Jocelyne Hamelin ◽  
Michel De Waard ◽  
Jacqueline Bréard ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Penetrating Peptides ◽  
Human Breast ◽  
Cell Penetrating ◽  
Induced Apoptosis

In vitro cytotoxicity and in vivo zebrafish toxicity evaluation of Ru(ii)/2-mercaptopyrimidine complexes

2019 ◽  
Vol 48 (18) ◽  
pp. 6026-6039 ◽  
Author(s):  
Vivianne S. Velozo-Sá ◽  
Luciano R. Pereira ◽  
Aliny P. Lima ◽  
Francyelli Mello-Andrade ◽  
Manuela R. M. Rezende ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Larval Development ◽  
In Vitro Cytotoxicity ◽  
Toxic Effects ◽  
Toxicity Evaluation ◽  
Embryonic And Larval Development

Ru(ii)/2-mercaptopyrimidine complexes active against cancer cells did not present toxic effects during embryonic and larval development of zebrafish.

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