Alterations to metabolically active bacteria in the mucosa of the small intestine predict anti-obesity and anti-diabetic activities of grape seed extract in mice

2017 ◽  
Vol 8 (10) ◽  
pp. 3510-3522 ◽  
Author(s):  
Laura E. Griffin ◽  
Katherine A. Witrick ◽  
Courtney Klotz ◽  
Melanie R. Dorenkott ◽  
Katheryn M. Goodrich ◽  
...  
Keyword(s):  
Small Intestine ◽  
Gut Microbiota ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Microbiota Composition ◽  
Active Bacteria ◽  
Small Intestinal ◽  
Gut Microbiota Composition

Grape seed extract changes small intestinal gut microbiota composition.

scholarly journals Hesperidin Effects on Gut Microbiota and Gut-Associated Lymphoid Tissue in Healthy Rats

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 324 ◽  
Author(s):  
Sheila Estruel-Amades ◽  
Malén Massot-Cladera ◽  
Francisco Pérez-Cano ◽  
Àngels Franch ◽  
Margarida Castell ◽  
...  
Keyword(s):  
Small Intestine ◽  
Gut Microbiota ◽  
Lymphoid Tissue ◽  
Relative Proportion ◽  
Interferon Γ ◽  
Biological Properties ◽  
Microbiota Composition ◽  
Chemotactic Protein ◽  
Wide Range ◽  
Gut Microbiota Composition

Hesperidin, found in citrus fruits, has shown a wide range of biological properties. Nonetheless, a more in-depth investigation is required on the effects on the immune system, and in particular, on the gut-associated lymphoid tissue, together with its relationship with the gut microbiota. Therefore, we aimed to establish the influence of oral hesperidin administration on the intestinal lymphoid tissue and on the gut microbiota composition in healthy animals. Lewis rats were orally administrated 100 or 200 mg/kg hesperidin three times per week for four weeks. Microbiota composition and IgA-coated bacteria were determined in caecal content. Mesenteric lymph node lymphocyte (MLNL) composition and functionality were assessed. IgA, cytokines, and gene expression in the small intestine were quantified. Hesperidin administration resulted in a higher number of bacteria and IgA-coated bacteria, with changes in microbiota composition such as higher Lactobacillus proportion. Hesperidin was also able to increase the small intestine IgA content. These changes in the small intestine were accompanied by a decrease in interferon-γ and monocyte chemotactic protein-1 concentration. In addition, hesperidin increased the relative proportion of TCRαβ+ lymphocytes in MLNL. These results show the immunomodulatory actions of hesperidin on the gut-associated lymphoid tissue and reinforce its role as a prebiotic.

scholarly journals Microscopic Modeling of País Grape Seed Extract Absorption in the Small Intestine

2013 ◽  
Vol 15 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Cristian Morales ◽  
Marlene Roeckel ◽  
Katherina Fernández
Keyword(s):  
Small Intestine ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Microscopic Modeling

Grape Seeds Extract as Brain Food: A Review

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Souad El Gengaihi ◽  
Doha H. Abou Baker
Keyword(s):  
Antioxidant Activities ◽  
Complex Mixture ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Amyloid Peptide ◽  
Grape Seeds ◽  
Potential Benefits ◽  
Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

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