Grape seed extract improves small intestinal health through suppressing inflammation and regulating alkaline phosphatase in IL-10-deficient mice

2016 ◽  
Vol 20 ◽  
pp. 245-252 ◽  
Author(s):  
Shima Bibi ◽  
Yifei Kang ◽  
Guan Yang ◽  
Mei-Jun Zhu
Keyword(s):  
Alkaline Phosphatase ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Intestinal Health ◽  
Small Intestinal ◽  
Deficient Mice

Alterations to metabolically active bacteria in the mucosa of the small intestine predict anti-obesity and anti-diabetic activities of grape seed extract in mice

2017 ◽  
Vol 8 (10) ◽  
pp. 3510-3522 ◽  
Author(s):  
Laura E. Griffin ◽  
Katherine A. Witrick ◽  
Courtney Klotz ◽  
Melanie R. Dorenkott ◽  
Katheryn M. Goodrich ◽  
...  
Keyword(s):  
Small Intestine ◽  
Gut Microbiota ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Microbiota Composition ◽  
Active Bacteria ◽  
Small Intestinal ◽  
Gut Microbiota Composition

Grape seed extract changes small intestinal gut microbiota composition.

scholarly journals Dietary grape seed extract ameliorates symptoms of inflammatory bowel disease in IL10-deficient mice

2013 ◽  
Vol 57 (12) ◽  
pp. 2253-2257 ◽  
Author(s):  
Hui Wang ◽  
Yansong Xue ◽  
Hanying Zhang ◽  
Yan Huang ◽  
Guan Yang ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Inflammatory Bowel ◽  
Deficient Mice

scholarly journals Favourable effects of grape seed extract on intestinal epithelial differentiation and barrier function in IL10-deficient mice

2015 ◽  
Vol 114 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Guan Yang ◽  
Yansong Xue ◽  
Hanying Zhang ◽  
Min Du ◽  
Mei-Jun Zhu
Keyword(s):  
Cell Proliferation ◽  
Cell Differentiation ◽  
Mrna Expression ◽  
Barrier Function ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Aetiological Factor ◽  
Gut Barrier Function ◽  
Deficient Mice

The impairment in the rate of cell proliferation and differentiation leads to a negative consequence on the renewal of the intestinal epithelium, which is the aetiological factor of a number of digestive diseases. Grape seed extract (GSE), a rich source of proanthocyanidins, is known for its beneficial health effects. The present study evaluated the beneficial effects of GSE on colonic cell differentiation and barrier function in IL10-deficient mice. Female mice aged 6 weeks were randomised into two groups and given drinking-water containing 0 or 0·1 % GSE (w/v) for 12 weeks. GSE supplementation decreased serum TNF-α level and intestinal permeability, and increased the colonic goblet cell density that was associated with increased mRNA expression of mucin (Muc)-2. Immunohistochemical analyses showed lower accumulation of β-catenin in the crypts of colon tissues of the GSE-supplemented mice, which was associated with a decreased mRNA expression of two downstream effectors of Wingless and Int (Wnt)/catenin signalling, myelocytomatosis oncogene protein (Myc) and cyclin D1 (Ccnd1). Consistently, GSE supplementation decreased the number of colonic proliferating cell nuclear antigen-positive cells, a well-known cell proliferation marker, and a weakened extracellular signal-regulated kinases 1 and 2 (ERK1/2) signalling. In summary, these data indicate that supplementation of 0·1 % GSE for 12 weeks improved gut barrier function and colonic cell differentiation in the IL10-deficient mice probably via inhibiting Wnt/β-catenin pathway.

Grape seed extract improves epithelial structure and suppresses inflammation in ileum of IL-10-deficient mice

2014 ◽  
Vol 5 (10) ◽  
pp. 2558-2563 ◽  
Author(s):  
Guan Yang ◽  
Hui Wang ◽  
Yifei Kang ◽  
Mei-Jun Zhu
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Etiological Factor ◽  
Intestinal Epithelial ◽  
Epithelial Structure ◽  
Inflammatory Bowel ◽  
Deficient Mice

Defect in intestinal epithelial structure is a critical etiological factor of several intestinal diseases such as inflammatory bowel disease.

Grape Seeds Extract as Brain Food: A Review

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Souad El Gengaihi ◽  
Doha H. Abou Baker
Keyword(s):  
Antioxidant Activities ◽  
Complex Mixture ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Amyloid Peptide ◽  
Grape Seeds ◽  
Potential Benefits ◽  
Reduced Risk

Interest in the biological role of bioactive compounds present in medicinal herbs has increased over the last years. Of particular interest are plants that have an anti-Alzheimer activities. Several plants can be useful for Alzheimer (AD) management. Such as these which have anti-inflammatory activity, acetylcholinesterase (AChE) inhibitory action, antiapoptotic, slow the aggregation of amyloid peptide and antioxidant activities. Grape seed extract (GSE) is a complex mixture of several compounds, mostly represented by polyphenols and flavonoids. Their consumption is safe and is recognized to exert several health benefits. GS flavonoids have been associated with the reduced risk of chronic diseases, we present some findings on the potential benefits of GSE for the treatment of AD.

Grape Seed Extract Complex (FFM-GS) Inhibits Postmenopausal Symptoms: In Vitro and In Vivo S

2019 ◽  
Vol 48 (3) ◽  
pp. 297-305
Author(s):  
Minhee Lee ◽  
Da-Eun Nam ◽  
Soo-Jeung Park ◽  
Dakyung Kim ◽  
Jeong-Moon Yun ◽  
...  
Keyword(s):  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Postmenopausal Symptoms

scholarly journals Comparative Evaluation of Immediate Bond Strength to Bleached Enamel Following Application of Various Antioxidant Solutions

2017 ◽  
Vol 05 (02) ◽  
pp. 084-089
Author(s):  
Alisha Dhingra ◽  
Ashu Gupta ◽  
Anshu Minocha ◽  
Nayantara Sen
Keyword(s):  
Bond Strength ◽  
Shear Bond Strength ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
The Other ◽  
Sodium Ascorbate ◽  
Group V ◽  
Group I ◽  
Significant Difference

Abstract Aim: The aim of this study was to compare the reversal of shear bond strength of composite to bleached enamel immediately after bleaching followed by application of various antioxidant solutions. Material and Methods: Seventy central incisors were divided into seven groups. Groups I and II served as unbleached and bleached controls respectively. Groups III, IV, V, VI and VII served as the experimental groups and were subjected to 37.5% hydrogen peroxide bleaching followed by 10 min application of 10% sodium ascorbate, 25% alpha-tocopherol, 6.5% grape seed extract, 5% lycopene and 5% green tea extract respectively. Following composite bonding, shear bond strength was determined and the results were analyzed using ANOVA followed by Post Hoc Multiple Comparisons test. Results: The bond strength values for Group I (positive control) were maximum and significantly different than all the other groups except Grape seed extract group (Group V). When compared to Group II (bleached control), all the groups showed significantly higher bond strength. Significant difference in the bond strength values were seen between Group III (10% sodium ascorbate) and Group V. Also values for Group V were significantly different from Group VI (5% lycopene). All the other values showed insignificantly different results. Conclusion: All the antioxidant solutions improved the shear bond strength values after bleaching but only Grape seed extract application reversed the values to the non bleached levels. Lycopene was least effective. Other antioxidants showed comparable results.

Incorporation of grape seed extract towards wound care product development

3 Biotech ◽  
2021 ◽  
Vol 11 (6) ◽  
Author(s):  
Amita Ajit ◽  
A. G. Vishnu ◽  
Prashanth Varkey
Keyword(s):  
Product Development ◽  
Wound Care ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Care Product
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