Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice

2017 ◽  
Vol 8 (3) ◽  
pp. 1282-1292 ◽  
Author(s):  
Mengfan Jia ◽  
Daoyuan Ren ◽  
Yan Nie ◽  
Xingbin Yang
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Injury ◽  
Hepatic Injury ◽  
Vascular Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Beneficial Effects ◽  
Apple Peel

APP could ameliorate HC diet-induced vascular dysfunction and hepatic injury.

Abstract 041: Elevated Circulating Copeptin in Mid-Gestation is Associated with Increased Aortic Stiffness and Vascular Endothelial Dysfunction in Pregnant Women at High Risk for Preeclampsia

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Gary L Pierce ◽  
Donna A Santillan ◽  
Diedre Fleener ◽  
Sabrina M Scroggins ◽  
Kimberlly K Leslie ◽  
...  
Keyword(s):  
High Risk ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Pregnant Women ◽  
Brachial Artery ◽  
Aortic Stiffness ◽  
Vascular Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Vascular Endothelial Function

Circulating copeptin, a stable biomarker of vasopressin (AVP) secretion, is elevated throughout pregnancy in women who develop preeclampsia (PreE) and is a strong predictor of PreE as early as the 6th week gestation. Reduced vascular endothelial function and increased aortic stiffness occur in mid-gestation before clinical signs/symptoms of PreE manifest, suggesting that maternal vascular dysfunction may be an early event in the pathogenesis of PreE. However, it is unknown whether elevated copeptin/AVP in early/mid gestation contributes to vascular dysfunction in pregnant women who subsequently develop PreE. Therefore, we hypothesized that elevated copeptin would be associated with increased aortic stiffness and reduced vascular endothelial function in early/mid gestation of pregnant women at high risk for PreE. Pregnant women in the 1st trimester (n=72; age=30 ±1 yrs; BMI=34 ± 1 kg/m2) with at least 1 risk factor for PreE were enrolled. Aortic stiffness (carotid-femoral pulse wave velocity, CFPWV), vascular endothelial function (brachial artery flow-mediated dilation, FMD), blood pressure (BP) and plasma copeptin (ELISA) were assessed in both the 1st (11.7 ± 0.2 wks) and 2nd (18.8 ± 0.4 wks) trimesters. In the 1st trimester, CFPWV (7.3 ± 0.2 vs. 7.3 ± 0.5 m/sec, P=0.86), brachial artery FMD (12.9 ± 1.1 vs. 14.3 ± 2.0%, P=0.53), BP, BMI and age did not differ between women in the highest (1513 ± 221 pg/ml) vs. lowest (279 ± 12 pg/ml) quartile of copeptin (P<0.01). In contrast, 2nd trimester CFPWV was greater (7.2 ± 0.2 vs. 6.4 ± 0.2 m/sec, P<0.05) and brachial artery FMD was lower (10.2 ± 2.8 vs. 16.5 ± 1.3 %, P<0.05) among women in the highest (1714 ± 481 pg/ml) vs. the lowest (249 ± 13 pg/ml) quartile of copeptin (P<0.01), in the absence of differences in BP, BMI or age. For the entire cohort, (log)copeptin was significantly correlated with CFPWV (r=0.23, P=0.04) and tended to correlate with FMD (r=-0.23, P=0.06) in the 2nd but not in the 1st trimester. These data suggest that elevated copeptin in mid-gestation is associated with aortic stiffness and vascular endothelial dysfunction in pregnant women at high risk for PreE, but whether increased copeptin/AVP causes vascular dysfunction in pregnancies destined for PreE requires further studies using animal models.

Abstract 133: Kidney-specific Conditional Knockout of Klotho Gene Impairs Natriuresis and Causes Arterial Stiffness and Hypertension

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Zhongjie Sun ◽  
Quaisar Ali
Keyword(s):  
Endothelial Dysfunction ◽  
Systolic Hypertension ◽  
Vascular Dysfunction ◽  
Conditional Knockout ◽  
Mesenteric Arteries ◽  
Kidney Cortex ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Arterial Stiffening ◽  
Klotho Gene

Background and Purpose: Deletion of Klotho leads to hypertension. The purpose of this study is to investigate if renal epithelial sodium channel (ENaC) contributes to klotho deficiency-induced hypertension. Methods and Results: We generated kidney-specific conditional klotho null (KspKL -/- ) mice and found out that renal alpha subunit of ENaC is significantly upregulated compared to wild type (WT) mice. Blood pressure measured by telemetry demonstrated systolic hypertension and elevated pulse pressure suggesting vascular dysfunction in KspKL -/- . Pulse wave velocity, a marker of arterial stiffening was significantly increased in KspKL -/- mice. Amiloride, an ENaC inhibitor, completely prevented systolic hypertension and arterial stiffening in KspKL -/- mice. Ex vivo vascular relaxing responses to acetylcholine were diminished in mesenteric arteries in KspKL -/- group, indicating that klotho deficiency causes vascular endothelial dysfunction. Interestingly, treatment with amiloride abolished Klotho deficiency-induced vascular endothelial dysfunction. We found that urinary sodium excretion (U Na V) was significantly impaired in KspKL -/- group. Na retention was also associated with a decrease in glomerular filtration rate (GFR), suggesting impaired renal function in KspKL -/- mice. Treatment with amiloride prevented sodium retention and improved GFR in KspKL -/- mice. Total renal nitric oxide bioavailabililty and eNOS activity were significantly decreased in KspKl -/- mice which was ameliorated by amiloride treatment. Histological and morphometric analysis showed glomerular and tubular damage in KspKL -/- , which was improved by amiloride treatment. Western blotting analysis demonstrated a significant decrease in the αγ subunits of ENaC in the kidney cortex following treatment with amiloride. Conclusion: This study demonstrates for the first time that kidney-specific depletion of the klotho gene causes impairment in Na-excretion and hypertension by affecting ENaCα levels. ENaC may be a promising therapeutic target for klotho gene deficiency-induced renal and vascular dysfunction and hypertension.

scholarly journals Endothelial Dysfunction in Cystic Fibrosis: Role of Oxidative Stress

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Matthew A. Tucker ◽  
Brandon M. Fox ◽  
Nichole Seigler ◽  
Paula Rodriguez-Miguelez ◽  
Jacob Looney ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cystic Fibrosis ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Vascular Dysfunction ◽  
Lipid Hydroperoxide ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Vascular Endothelial Function ◽  
Artery Flow

Oxidative stress and vascular endothelial dysfunction are established characteristics of cystic fibrosis (CF). Oxidative stress may contribute to vascular dysfunction via inhibition of nitric oxide (NO) bioavailability. Purpose. To determine if ingestion of a single antioxidant cocktail (AOC) improves vascular endothelial function in patients with CF. Methods. In 18 patients with CF (age 8-39 y), brachial artery flow-mediated dilation (FMD) was assessed using a Doppler ultrasound prior to and two hours following either an AOC (n=18; 1,000 mg vitamin C, 600 IU vitamin E, and 600 mg α-lipoic acid) or a placebo (n=9). In a subgroup of patients (n=9), changes in serum concentrations of α-tocopherol and lipid hydroperoxide (LOOH) were assessed following AOC and placebo. Results. A significant (p=0.032) increase in FMD was observed following AOC (Δ1.9±3.3%), compared to no change following placebo (Δ−0.8±1.9%). Moreover, compared with placebo, AOC prevented the decrease in α-tocopherol (Δ0.48±2.91 vs. −1.98±2.32 μM, p=0.024) and tended to decrease LOOH (Δ−0.2±0.1 vs. 0.1±0.1 μM, p=0.063). Conclusions. These data demonstrate that ingestion of an antioxidant cocktail can improve vascular endothelial function and improve oxidative stress in patients with CF, providing evidence that oxidative stress is a key contributor to vascular endothelial dysfunction in CF.

scholarly journals Beneficial Effects of Donepezil on Vascular Endothelial Dysfunction-Associated Dementia Induced by L-Methionine in Rats

2009 ◽  
Vol 55 (2) ◽  
pp. 215-225 ◽  
Author(s):  
Rajeshkumar Ukabhi Koladiya ◽  
Amteshwar Singh Jaggi ◽  
Nirmal Singh ◽  
Bhupesh Kumar Sharma
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Beneficial Effects

Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?

2001 ◽  
Vol 281 (3) ◽  
pp. H981-H986 ◽  
Author(s):  
Zvonimir S. Katusic
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Ischemia Reperfusion ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Vascular Effects ◽  
Beneficial Effects ◽  
Oxide Synthase

Tetrahydrobiopterin is one of the most potent naturally occurring reducing agents and an essential cofactor required for enzymatic activity of nitric oxide synthase (NOS). The exact role of tetrahydrobiopterin in the control of NOS catalytic activity is not completely understood. Existing evidence suggests that it can act as alosteric and redox cofactors. Suboptimal concentration of tetrahydrobiopterin reduces formation of nitric oxide and favors “uncoupling” of NOS leading to NOS-mediated reduction of oxygen and formation of superoxide anions and hydrogen peroxide. Recent findings suggest that accelerated catabolism of tetrahydrobiopterin in arteries exposed to oxidative stress may contribute to pathogenesis of endothelial dysfunction present in arteries exposed to hypertension, hypercholesterolemia, diabetes, smoking, and ischemia-reperfusion. Beneficial effects of acute and chronic tetrahydrobiopterin supplementation on endothelial function have been reported in experimental animals and humans. Furthermore, it appears that beneficial effects of some antioxidants (e.g., vitamin C) on vascular function could be mediated via increased intracellular concentration of tetrahydrobiopterin. In this review, the potential role of tetrahydrobiopterin in the pathogenesis of vascular endothelial dysfunction and mechanisms underlying beneficial vascular effects of tetrahydrobiopterin will be discussed.

Myricetin derived from Hovenia dulcis Thunb. ameliorates vascular endothelial dysfunction and liver injury in high choline-fed mice

2015 ◽  
Vol 6 (5) ◽  
pp. 1620-1634 ◽  
Author(s):  
Jianjun Guo ◽  
Yonghong Meng ◽  
Yan Zhao ◽  
Yuanyuan Hu ◽  
Daoyuan Ren ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Injury ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
Dietary Choline ◽  
Hovenia Dulcis

The present study was conducted to explore the protective effects of myricetin (MYR) purified from Hovenia dulcis Thunb. against vascular endothelial dysfunction and liver injury in mice fed with 3% dietary choline water.

scholarly journals Piper sarmentosum Roxb. Attenuates Vascular Endothelial Dysfunction in Nicotine-Induced Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Muhd Fakh Rur Razi Md. Salleh ◽  
Amilia Aminuddin ◽  
Adila A. Hamid ◽  
Norizam Salamt ◽  
Fadhlullah Zuhair Japar Sidik ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cigarette Smoke ◽  
Vascular Dysfunction ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Nicotine Administration ◽  
Sprague Dawley Rats

Exposure to cigarette smoke is an important risk factor for cardiovascular diseases. Nicotine is an addictive compound in cigarette smoke that triggers oxidative stress, which leads to vascular dysfunction. Piper sarmentosum Roxb. is a herb with antioxidant and vascular protective effects. This study evaluated the potential protective effect of the aqueous extract of P. sarmentosum leaf (AEPS) on vascular dysfunction in rats induced with prolonged nicotine administration. A total of 22 male Sprague-Dawley rats were divided into control (normal saline, oral gavage [p.o.]), nicotine (0.8 mg/kg/day nicotine, intraperitoneally [i.p.]), and nicotine + AEPS groups (250 mg/kg/day AEPS, p.o. + 0.8 mg/kg/day nicotine, i.p.). Treatment was given for 21 days. Thoracic aortae were harvested from the rats for the measurement of vasorelaxation, vascular nitric oxide (NO) level, and antioxidant level and the assessment of vascular remodeling. Rats treated with AEPS had improved vasorelaxation to endothelium-dependent vasodilator, acetylcholine (ACh), compared with the nicotine-induced rats (p &lt; 0.05). The presence of endothelium increased the maximum relaxation of aortic rings in response to ACh. Compared with the nicotine group, AEPS enhanced vascular NO level (p &lt; 0.001) and increased antioxidant levels as measured by superoxide dismutase activity (p &lt; 0.05), catalase activity (p &lt; 0.01), and reduced glutathione level (p &lt; 0.05). No remarkable changes in aortic histomorphometry were detected. In conclusion, P. sarmentosum attenuates vascular endothelial dysfunction in nicotine-induced rats by improving vasorelaxation and enhancing vascular NO and antioxidant levels.

Chemical characteristics of an Ilex Kuding tea polysaccharide and its protective effects against high fructose-induced liver injury and vascular endothelial dysfunction in mice

2017 ◽  
Vol 8 (7) ◽  
pp. 2536-2547 ◽  
Author(s):  
Xichuan Zhai ◽  
Daoyuan Ren ◽  
Yiyang Luo ◽  
Yuanyuan Hu ◽  
Xingbin Yang
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Injury ◽  
Chemical Characteristics ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
High Fructose ◽  
Tea Polysaccharides

The present study was designed to investigate the protective effects of Ilex Kuding tea polysaccharides (IKTP) on high fructose (HF)-induced liver injury and vascular endothelial dysfunction in mice.

Sign in / Sign up

Export Citation Format

Share Document