Myricetin derived from Hovenia dulcis Thunb. ameliorates vascular endothelial dysfunction and liver injury in high choline-fed mice

2015 ◽  
Vol 6 (5) ◽  
pp. 1620-1634 ◽  
Author(s):  
Jianjun Guo ◽  
Yonghong Meng ◽  
Yan Zhao ◽  
Yuanyuan Hu ◽  
Daoyuan Ren ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Injury ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
Dietary Choline ◽  
Hovenia Dulcis

The present study was conducted to explore the protective effects of myricetin (MYR) purified from Hovenia dulcis Thunb. against vascular endothelial dysfunction and liver injury in mice fed with 3% dietary choline water.

Chemical characteristics of an Ilex Kuding tea polysaccharide and its protective effects against high fructose-induced liver injury and vascular endothelial dysfunction in mice

2017 ◽  
Vol 8 (7) ◽  
pp. 2536-2547 ◽  
Author(s):  
Xichuan Zhai ◽  
Daoyuan Ren ◽  
Yiyang Luo ◽  
Yuanyuan Hu ◽  
Xingbin Yang
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Injury ◽  
Chemical Characteristics ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
High Fructose ◽  
Tea Polysaccharides

The present study was designed to investigate the protective effects of Ilex Kuding tea polysaccharides (IKTP) on high fructose (HF)-induced liver injury and vascular endothelial dysfunction in mice.

Beneficial effects of apple peel polyphenols on vascular endothelial dysfunction and liver injury in high choline-fed mice

2017 ◽  
Vol 8 (3) ◽  
pp. 1282-1292 ◽  
Author(s):  
Mengfan Jia ◽  
Daoyuan Ren ◽  
Yan Nie ◽  
Xingbin Yang
Keyword(s):  
Endothelial Dysfunction ◽  
Liver Injury ◽  
Hepatic Injury ◽  
Vascular Dysfunction ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction ◽  
Beneficial Effects ◽  
Apple Peel

APP could ameliorate HC diet-induced vascular dysfunction and hepatic injury.

scholarly journals Piper sarmentosum Roxb. Attenuates Vascular Endothelial Dysfunction in Nicotine-Induced Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Muhd Fakh Rur Razi Md. Salleh ◽  
Amilia Aminuddin ◽  
Adila A. Hamid ◽  
Norizam Salamt ◽  
Fadhlullah Zuhair Japar Sidik ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cigarette Smoke ◽  
Vascular Dysfunction ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Vascular Endothelial Dysfunction ◽  
Sprague Dawley ◽  
Oral Gavage ◽  
Nicotine Administration ◽  
Sprague Dawley Rats

Exposure to cigarette smoke is an important risk factor for cardiovascular diseases. Nicotine is an addictive compound in cigarette smoke that triggers oxidative stress, which leads to vascular dysfunction. Piper sarmentosum Roxb. is a herb with antioxidant and vascular protective effects. This study evaluated the potential protective effect of the aqueous extract of P. sarmentosum leaf (AEPS) on vascular dysfunction in rats induced with prolonged nicotine administration. A total of 22 male Sprague-Dawley rats were divided into control (normal saline, oral gavage [p.o.]), nicotine (0.8 mg/kg/day nicotine, intraperitoneally [i.p.]), and nicotine + AEPS groups (250 mg/kg/day AEPS, p.o. + 0.8 mg/kg/day nicotine, i.p.). Treatment was given for 21 days. Thoracic aortae were harvested from the rats for the measurement of vasorelaxation, vascular nitric oxide (NO) level, and antioxidant level and the assessment of vascular remodeling. Rats treated with AEPS had improved vasorelaxation to endothelium-dependent vasodilator, acetylcholine (ACh), compared with the nicotine-induced rats (p < 0.05). The presence of endothelium increased the maximum relaxation of aortic rings in response to ACh. Compared with the nicotine group, AEPS enhanced vascular NO level (p < 0.001) and increased antioxidant levels as measured by superoxide dismutase activity (p < 0.05), catalase activity (p < 0.01), and reduced glutathione level (p < 0.05). No remarkable changes in aortic histomorphometry were detected. In conclusion, P. sarmentosum attenuates vascular endothelial dysfunction in nicotine-induced rats by improving vasorelaxation and enhancing vascular NO and antioxidant levels.

Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction

Cell Cycle ◽  
2021 ◽  
pp. 1-13
Author(s):  
Qian-Qian Zhu ◽  
Xi-Bin Pu ◽  
Tian-Chi Chen ◽  
Chen-Yang Qiu ◽  
Zi-Heng Wu ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
High Glucose ◽  
Vascular Endothelial ◽  
Vascular Endothelial Dysfunction
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