scholarly journals Lipid-Shelled Vehicles: Engineering for Ultrasound Molecular Imaging and Drug Delivery

2009 ◽  
Vol 42 (7) ◽  
pp. 881-892 ◽  
Author(s):  
Katherine W. Ferrara ◽  
Mark A. Borden ◽  
Hua Zhang
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Ultrasound Molecular Imaging

scholarly journals The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 119
Author(s):  
Simone A.G. Langeveld ◽  
Inés Beekers ◽  
Gonzalo Collado-Lara ◽  
Antonius F. W. van der Steen ◽  
Nico de Jong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
High Speed ◽  
Phase Distribution ◽  
Direct Method ◽  
Ultrasound Contrast Agents ◽  
Lipid Phase ◽  
Acoustic Behavior ◽  
Ultrasound Molecular Imaging ◽  
The Impact

Phospholipid-coated microbubbles are ultrasound contrast agents that can be employed for ultrasound molecular imaging and drug delivery. For safe and effective implementation, microbubbles must respond uniformly and predictably to ultrasound. Therefore, we investigated how lipid handling and phase distribution affected the variability in the acoustic behavior of microbubbles. Cholesterol was used to modify the lateral molecular packing of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)-based microbubbles. To assess the effect of lipid handling, microbubbles were produced by a direct method, i.e., lipids directly dispersed in an aqueous medium or indirect method, i.e., lipids first dissolved in an organic solvent. The lipid phase and ligand distribution in the microbubble coating were investigated using confocal microscopy, and the acoustic response was recorded with the Brandaris 128 ultra-high-speed camera. In microbubbles with 12 mol% cholesterol, the lipids were miscible and all in the same phase, which resulted in more buckle formation, lower shell elasticity and higher shell viscosity. Indirect DSPC microbubbles had a more uniform response to ultrasound than direct DSPC and indirect DSPC-cholesterol microbubbles. The difference in lipid handling between direct and indirect DSPC microbubbles significantly affected the acoustic behavior. Indirect DSPC microbubbles are the most promising candidate for ultrasound molecular imaging and drug delivery applications.

Ultrasound molecular imaging-guided tumor gene therapy through dual-targeted cationic microbubbles

2021 ◽  
Vol 9 (7) ◽  
pp. 2454-2466
Author(s):  
Yingying Liu ◽  
Yuli Zhou ◽  
Jinfeng Xu ◽  
Hui Luo ◽  
Yao Zhu ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Molecular Imaging ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Tumor Gene Therapy ◽  
Ultrasound Molecular Imaging ◽  
Tumor Gene

A novel dual-targeted cationic microbubbles help to improve gene transfection efficiency.

Gold nanoparticle (AuNP)-based drug delivery and molecular imaging for biomedical applications

2013 ◽  
Vol 37 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Eun Hye Jeong ◽  
Giyoung Jung ◽  
Cheol Am Hong ◽  
Hyukjin Lee
Keyword(s):  
Drug Delivery ◽  
Molecular Imaging ◽  
Gold Nanoparticle ◽  
Biomedical Applications

Designed Ankyrin Repeat Proteins as Novel Binders for Ultrasound Molecular Imaging

2021 ◽  
Author(s):  
Alexandra Kosareva ◽  
Mukesh Punjabi ◽  
Amanda Ochoa-Espinosa ◽  
Lifen Xu ◽  
Jonas V. Schaefer ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Ankyrin Repeat ◽  
Repeat Proteins ◽  
Ultrasound Molecular Imaging ◽  
Ankyrin Repeat Proteins

scholarly journals First-in-Human Ultrasound Molecular Imaging With a VEGFR2-Specific Ultrasound Molecular Contrast Agent (BR55) in Prostate Cancer

2017 ◽  
Vol 52 (7) ◽  
pp. 419-427 ◽  
Author(s):  
Martijn Smeenge ◽  
François Tranquart ◽  
Christophe K. Mannaerts ◽  
Theo M. de Reijke ◽  
Marc J. van de Vijver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Imaging ◽  
Contrast Agent ◽  
Ultrasound Molecular Imaging ◽  
Molecular Contrast
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