Fluorescence imaging of antibiotic clofazimine encapsulated within mesoporous silica particle carriers: relevance to drug delivery and the effect on its release kinetics

2018 ◽  
Vol 20 (17) ◽  
pp. 11899-11911 ◽  
Author(s):  
Lorenzo Angiolini ◽  
Sabrina Valetti ◽  
Boiko Cohen ◽  
Adam Feiler ◽  
Abderrazzak Douhal
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Silica Particle ◽  
Release Kinetics ◽  
Silica Particles ◽  
Time Resolved ◽  
Mesoporous Silica Particle

Time-resolved FLIM experiments show how hydrophobicity and hydrophilicity of mesoporous silica particles affect the distribution and release of the loaded antibiotic clofazimine.

A gourd-like hollow mesoporous silica particle-supported Ag/AgBr Schottky junction for highly efficient mineralization of tetracycline hydrochloride

2020 ◽  
Vol 7 (9) ◽  
pp. 2654-2668
Author(s):  
Wei Li ◽  
Xiao-shan Chu ◽  
Shu-ao He ◽  
Xue-chuan Wang ◽  
Chuan-yi Wang
Keyword(s):  
Mesoporous Silica ◽  
Surface Area ◽  
Silica Particle ◽  
Silica Particles ◽  
Large Surface Area ◽  
Tetracycline Hydrochloride ◽  
Schottky Junction ◽  
Highly Efficient ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Particle

Gourd-like hollow mesoporous silica particles with large surface area supporting the Ag/AgBr Schottky junction for a high-efficieny TTC mineralization.

Mesoporous silica particle-PLA–PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization

Nanoscale ◽  
2015 ◽  
Vol 7 (34) ◽  
pp. 14434-14443 ◽  
Author(s):  
Hussein Shokry ◽  
Ulriika Vanamo ◽  
Oliver Wiltschka ◽  
Jenni Niinimäki ◽  
Martina Lerche ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Particle ◽  
Intracellular Drug Delivery ◽  
Hybrid Scaffolds ◽  
Mesoporous Silica Particle

scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

Biotemplated Hollow Mesoporous Silica Particles as Efficient Carriers for Drug Delivery

2021 ◽  
Author(s):  
Marzieh Heidari Nia ◽  
Roya Koshani ◽  
Jose G. Munguia-Lopez ◽  
Ali Reza Kiasat ◽  
Joseph M. Kinsella ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Particles ◽  
Hollow Mesoporous Silica

scholarly journals Myristic Acid Coated Protein Immobilised Mesoporous Silica Particles as pH Induced Oral Delivery System for the Delivery of Biomolecules

2019 ◽  
Vol 12 (4) ◽  
pp. 153
Author(s):  
Vivek Trivedi ◽  
Ruchir Bhomia ◽  
John C Mitchell
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Protein Conformation ◽  
Myristic Acid ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Silica Particles ◽  
Protein Release ◽  
Simulated Gastric Fluid

Solid core drug delivery systems (SCDDS) were prepared for the oral delivery of biomolecules using mesoporous silica as core, bovine haemoglobin (bHb) as model drug and supercritical fluid (SCF) processing as encapsulation technique. The use of organic solvents or harsh processing conditions in the development of drug delivery systems for biomolecules can be detrimental for the structural integrity of the molecule. Hence, the coating on protein-immobilised particles was performed via supercritical carbon dioxide (scCO2) processing at a temperature lower than the melting point of myristic acid (MA) to avoid any thermal degradation of bHb. The SCDDS were prepared by bHb immobilisation on mesoporous silica followed by myristic acid (MA) coating at 43 °C and 100 bar in scCO2. bHb-immobilised silica particles were also coated via solvent evaporation (SE) to compare the protein release with scCO2 processed formulations. In both cases, MA coating provided required enteric protection and restricted the bHb release for the first two hours in simulated gastric fluid (SGF). The protein release was immediate upon the change of media to simulated intestinal fluid (SIF), reaching 70% within three hours. The release from SCF processed samples was slower than SE formulations, indicating superior surface coverage of MA on particles in comparison to the SE method. Most importantly, the protein conformation remained unchanged after the release from SCDDS as confirmed by circular dichroism. This study clearly demonstrates that the approach involving protein immobilisation on silica and scCO2 assisted melt-coating method can protect biomolecules from gastric environment and provide the required release of a biologic in intestine without any untoward effects on protein conformation during processing or after release.

Synthesis of Mesoporous Silica Particles with Fibrous Morphology via Self-Assembly Process in Microemulsion System

2015 ◽  
Vol 1112 ◽  
pp. 172-175 ◽  
Author(s):  
Erna Febriyanti ◽  
Rino R. Mukti ◽  
Veinardi Suendo ◽  
I. Nyoman Marsih ◽  
Sugeng Triwahyono ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Mesoporous Silica ◽  
Surface Area ◽  
Self Assembly ◽  
Silica Particle ◽  
High Surface ◽  
Microemulsion System ◽  
Assembly Process ◽  
Fibrous Materials ◽  
Mesoporous Silica Particle

In this research, several precursors were chosen to solve the drawbacks of using toxic and expensive chemicals in the synthesis of fibrous mesoporous silica particle via self-assembly process in microemulsion system. The synthesis of this emerging material normally is realized by using toxic cetylpyridinium bromide (CPB) as common structure directing agent in conjunction with combined cyclohexane and n-pentanol as expensive solvent and co-solvent, respectively. Less toxic cetyltrimethylammonium bromide (CTAB) can be the replacement for CPB but the use of this surfactant may drastically reduce the surface area of the resulting product. Herein, we report that the use of CTAB with combined toluene and n-butanol as affordable solvents can be used to synthesize fibrous mesoporous silica particle with high surface area. The material was well characterized by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), N2 adsorption/ desorption, X-ray difraction (XRD)and thermal gravimetry (TG). This material might be applied in potential applications such as catalysis, drug delivery and adsorption. Moreover, it can be used as a hard-template for fabricating another novel fibrous materials.

Functionalized Mesoporous Silica Particles for Application in Drug Delivery System

2012 ◽  
Vol 12 (8) ◽  
pp. 775-788 ◽  
Author(s):  
J. Pang ◽  
Y. Luan ◽  
X. Yang ◽  
Y. Jiang ◽  
L. Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Silica Particles ◽  
Functionalized Mesoporous Silica
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