Mesoporous silica particle-PLA–PANI hybrid scaffolds for cell-directed intracellular drug delivery and tissue vascularization

Nanoscale ◽  
2015 ◽  
Vol 7 (34) ◽  
pp. 14434-14443 ◽  
Author(s):  
Hussein Shokry ◽  
Ulriika Vanamo ◽  
Oliver Wiltschka ◽  
Jenni Niinimäki ◽  
Martina Lerche ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Particle ◽  
Intracellular Drug Delivery ◽  
Hybrid Scaffolds ◽  
Mesoporous Silica Particle

Fluorescence imaging of antibiotic clofazimine encapsulated within mesoporous silica particle carriers: relevance to drug delivery and the effect on its release kinetics

2018 ◽  
Vol 20 (17) ◽  
pp. 11899-11911 ◽  
Author(s):  
Lorenzo Angiolini ◽  
Sabrina Valetti ◽  
Boiko Cohen ◽  
Adam Feiler ◽  
Abderrazzak Douhal
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Silica Particle ◽  
Release Kinetics ◽  
Silica Particles ◽  
Time Resolved ◽  
Mesoporous Silica Particle

Time-resolved FLIM experiments show how hydrophobicity and hydrophilicity of mesoporous silica particles affect the distribution and release of the loaded antibiotic clofazimine.

scholarly journals Factors Affecting Intracellular Delivery and Release of Hydrophilic Versus Hydrophobic Cargo from Mesoporous Silica Nanoparticles on 2D and 3D Cell Cultures

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 237 ◽  
Author(s):  
Diti Desai ◽  
Malin Åkerfelt ◽  
Neeraj Prabhakar ◽  
Mervi Toriseva ◽  
Tuomas Näreoja ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Surface Charge ◽  
Silica Nanoparticles ◽  
Lipid Bilayers ◽  
Mesoporous Silica Nanoparticles ◽  
Cellular Level ◽  
Dependent Manner ◽  
Ethylene Imine ◽  
Intracellular Drug Delivery

Intracellular drug delivery by mesoporous silica nanoparticles (MSNs) carrying hydrophilic and hydrophobic fluorophores as model drug cargo is demonstrated on 2D cellular and 3D tumor organoid level. Two different MSN designs, chosen on the basis of the characteristics of the loaded cargo, were used: MSNs with a surface-grown poly(ethylene imine), PEI, coating only for hydrophobic cargo and MSNs with lipid bilayers covalently coupled to the PEI layer as a diffusion barrier for hydrophilic cargo. First, the effect of hydrophobicity corresponding to loading degree (hydrophobic cargo) as well as surface charge (hydrophilic cargo) on intracellular drug release was studied on the cellular level. All incorporated agents were able to release to varying degrees from the endosomes into the cytoplasm in a loading degree (hydrophobic) or surface charge (hydrophilic) dependent manner as detected by live cell imaging. When administered to organotypic 3D tumor models, the hydrophilic versus hydrophobic cargo-carrying MSNs showed remarkable differences in labeling efficiency, which in this case also corresponds to drug delivery efficacy in 3D. The obtained results could thus indicate design aspects to be taken into account for the development of efficacious intracellular drug delivery systems, especially in the translation from standard 2D culture to more biologically relevant organotypic 3D cultures.

A gourd-like hollow mesoporous silica particle-supported Ag/AgBr Schottky junction for highly efficient mineralization of tetracycline hydrochloride

2020 ◽  
Vol 7 (9) ◽  
pp. 2654-2668
Author(s):  
Wei Li ◽  
Xiao-shan Chu ◽  
Shu-ao He ◽  
Xue-chuan Wang ◽  
Chuan-yi Wang
Keyword(s):  
Mesoporous Silica ◽  
Surface Area ◽  
Silica Particle ◽  
Silica Particles ◽  
Large Surface Area ◽  
Tetracycline Hydrochloride ◽  
Schottky Junction ◽  
Highly Efficient ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Particle

Gourd-like hollow mesoporous silica particles with large surface area supporting the Ag/AgBr Schottky junction for a high-efficieny TTC mineralization.

Synthesis of Mesoporous Silica Particles with Fibrous Morphology via Self-Assembly Process in Microemulsion System

2015 ◽  
Vol 1112 ◽  
pp. 172-175 ◽  
Author(s):  
Erna Febriyanti ◽  
Rino R. Mukti ◽  
Veinardi Suendo ◽  
I. Nyoman Marsih ◽  
Sugeng Triwahyono ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Mesoporous Silica ◽  
Surface Area ◽  
Self Assembly ◽  
Silica Particle ◽  
High Surface ◽  
Microemulsion System ◽  
Assembly Process ◽  
Fibrous Materials ◽  
Mesoporous Silica Particle

In this research, several precursors were chosen to solve the drawbacks of using toxic and expensive chemicals in the synthesis of fibrous mesoporous silica particle via self-assembly process in microemulsion system. The synthesis of this emerging material normally is realized by using toxic cetylpyridinium bromide (CPB) as common structure directing agent in conjunction with combined cyclohexane and n-pentanol as expensive solvent and co-solvent, respectively. Less toxic cetyltrimethylammonium bromide (CTAB) can be the replacement for CPB but the use of this surfactant may drastically reduce the surface area of the resulting product. Herein, we report that the use of CTAB with combined toluene and n-butanol as affordable solvents can be used to synthesize fibrous mesoporous silica particle with high surface area. The material was well characterized by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), N2 adsorption/ desorption, X-ray difraction (XRD)and thermal gravimetry (TG). This material might be applied in potential applications such as catalysis, drug delivery and adsorption. Moreover, it can be used as a hard-template for fabricating another novel fibrous materials.

Mesoporous silica-giant particle with slit pore arrangement as an adsorbent for heavy metal oxyanions from aqueous medium

RSC Advances ◽  
2015 ◽  
Vol 5 (14) ◽  
pp. 10260-10266 ◽  
Author(s):  
Seenu Ravi ◽  
Roshith Roshan ◽  
Jose Tharun ◽  
Dae-Won Park ◽  
Ho-Hwan Chun ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Mesoporous Silica ◽  
Aqueous Medium ◽  
Silica Particle ◽  
Adsorption Studies ◽  
Slit Pore ◽  
Pore Arrangement ◽  
Mesoporous Silica Particle

A newly synthesized giant mesoporous silica particle has been used for arsenate and chromate adsorption studies.

Sign in / Sign up

Export Citation Format

Share Document