Biotemplated Hollow Mesoporous Silica Particles as Efficient Carriers for Drug Delivery

2021 ◽  
Author(s):  
Marzieh Heidari Nia ◽  
Roya Koshani ◽  
Jose G. Munguia-Lopez ◽  
Ali Reza Kiasat ◽  
Joseph M. Kinsella ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Particles ◽  
Hollow Mesoporous Silica

A soft–hard template approach towards hollow mesoporous silica nanoparticles with rough surfaces for controlled drug delivery and protein adsorption

2015 ◽  
Vol 3 (31) ◽  
pp. 6480-6489 ◽  
Author(s):  
Haijiao Zhang ◽  
Huijuan Xu ◽  
Minghong Wu ◽  
Yufang Zhong ◽  
Donghai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Protein Adsorption ◽  
Rough Surfaces ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Hard Template ◽  
Hollow Mesoporous Silica

Novel hollow mesoporous silica nanoparticles (HMSNs) with rough surfaces have been successfully prepared using a facile soft–hard template route.

AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging

2016 ◽  
Vol 22 (11) ◽  
pp. 3681-3685 ◽  
Author(s):  
Zhiying Fan ◽  
Dongdong Li ◽  
Xue Yu ◽  
Yuping Zhang ◽  
Yong Cai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cell Imaging ◽  
Silica Nanospheres ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Nanospheres

A gourd-like hollow mesoporous silica particle-supported Ag/AgBr Schottky junction for highly efficient mineralization of tetracycline hydrochloride

2020 ◽  
Vol 7 (9) ◽  
pp. 2654-2668
Author(s):  
Wei Li ◽  
Xiao-shan Chu ◽  
Shu-ao He ◽  
Xue-chuan Wang ◽  
Chuan-yi Wang
Keyword(s):  
Mesoporous Silica ◽  
Surface Area ◽  
Silica Particle ◽  
Silica Particles ◽  
Large Surface Area ◽  
Tetracycline Hydrochloride ◽  
Schottky Junction ◽  
Highly Efficient ◽  
Hollow Mesoporous Silica ◽  
Mesoporous Silica Particle

Gourd-like hollow mesoporous silica particles with large surface area supporting the Ag/AgBr Schottky junction for a high-efficieny TTC mineralization.

Redox stimuli-responsive hollow mesoporous silica nanocarriers for targeted drug delivery in cancer therapy

2016 ◽  
Vol 1 (6) ◽  
pp. 480-487 ◽  
Author(s):  
Ye Tian ◽  
Ranran Guo ◽  
Yunfeng Jiao ◽  
Yangfei Sun ◽  
Shun Shen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Targeted Drug Delivery ◽  
Tumor Targeting ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Disulfide Linkages ◽  
Targeting Delivery ◽  
Targeted Drug ◽  
Hollow Mesoporous Silica

Transferrin-capped hollow mesoporous silica nanoparticles through disulfide linkages realize tumor-targeting delivery and glutathione-induced drug release.

scholarly journals Myristic Acid Coated Protein Immobilised Mesoporous Silica Particles as pH Induced Oral Delivery System for the Delivery of Biomolecules

2019 ◽  
Vol 12 (4) ◽  
pp. 153
Author(s):  
Vivek Trivedi ◽  
Ruchir Bhomia ◽  
John C Mitchell
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Protein Conformation ◽  
Myristic Acid ◽  
Oral Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Silica Particles ◽  
Protein Release ◽  
Simulated Gastric Fluid

Solid core drug delivery systems (SCDDS) were prepared for the oral delivery of biomolecules using mesoporous silica as core, bovine haemoglobin (bHb) as model drug and supercritical fluid (SCF) processing as encapsulation technique. The use of organic solvents or harsh processing conditions in the development of drug delivery systems for biomolecules can be detrimental for the structural integrity of the molecule. Hence, the coating on protein-immobilised particles was performed via supercritical carbon dioxide (scCO2) processing at a temperature lower than the melting point of myristic acid (MA) to avoid any thermal degradation of bHb. The SCDDS were prepared by bHb immobilisation on mesoporous silica followed by myristic acid (MA) coating at 43 °C and 100 bar in scCO2. bHb-immobilised silica particles were also coated via solvent evaporation (SE) to compare the protein release with scCO2 processed formulations. In both cases, MA coating provided required enteric protection and restricted the bHb release for the first two hours in simulated gastric fluid (SGF). The protein release was immediate upon the change of media to simulated intestinal fluid (SIF), reaching 70% within three hours. The release from SCF processed samples was slower than SE formulations, indicating superior surface coverage of MA on particles in comparison to the SE method. Most importantly, the protein conformation remained unchanged after the release from SCDDS as confirmed by circular dichroism. This study clearly demonstrates that the approach involving protein immobilisation on silica and scCO2 assisted melt-coating method can protect biomolecules from gastric environment and provide the required release of a biologic in intestine without any untoward effects on protein conformation during processing or after release.

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