scholarly journals To cage or to be caged? The cytotoxic species in ruthenium-based photoactivated chemotherapy is not always the metal

2017 ◽  
Vol 53 (50) ◽  
pp. 6768-6771 ◽  
Author(s):  
Jordi-Amat Cuello-Garibo ◽  
Michael S. Meijer ◽  
Sylvestre Bonnet
Keyword(s):  
Metal Complex ◽  
Free Ligand

In metal-based photoactivated chemotherapy (PACT), two photoproducts are generated by light-triggered photosubstitution of a metal-bound ligand: the free ligand itself and an aquated metal complex.

Synthesis of free and ligated 1,2-thiaphosphetanes – expanding the pool of strained P-ligands

2019 ◽  
Vol 55 (11) ◽  
pp. 1615-1618 ◽  
Author(s):  
Andreas Wolfgang Kyri ◽  
Florian Gleim ◽  
David Becker ◽  
Gregor Schnakenburg ◽  
Arturo Espinosa Ferao ◽  
...  
Keyword(s):  
Metal Complex ◽  
Coordination Sphere ◽  
Free Ligand ◽  
First Time ◽  
P Ligands

The 1,2-thiaphosphetane heterocycle could be synthesized for the first time in the coordination sphere of a metal complex (I) from which the free ligand (II) could be obtained, too.

Synthesis and Structure of the First Transition Metal Complex with Methanesulfonylhydrazine as a Ligand

2002 ◽  
Vol 57 (8) ◽  
pp. 865-867 ◽  
Author(s):  
A. Ienco ◽  
C. Mealli ◽  
N. I. Dodoff
Keyword(s):  
Transition Metal ◽  
Transition State ◽  
Metal Complex ◽  
Ab Initio Calculations ◽  
Ab Initio ◽  
Stationary Point ◽  
Transition Metal Complex ◽  
Free Ligand ◽  
Coordination Geometry ◽  
X Ray

The article reports the first transitionmetal complex of methanesulfonylhydrazine, a molecule known for important pharmacological and chemical applications. The complex [ZnCl2(MSH)2], MSH = CH3SO2NHNH2, has been synthesized and its structure characterized by means of X-ray analysis. The coordination geometry is pseudo-tetrahedral and the ligand MSH adopts a conformation that was found by previous ab initio calculations to be a transition state and not a stationary point for the free ligand.

On An Extension of the Use of pH-Titrations for Determination of Free Metal and Free Ligand Concentrations During Metal Complex Formation

1973 ◽  
Vol 51 (21) ◽  
pp. 3572-3576 ◽  
Author(s):  
W. A. E. McBryde
Keyword(s):  
Complex Formation ◽  
Metal Complex ◽  
Metal Complexes ◽  
Metal Concentration ◽  
Free Ligand ◽  
Ligand Concentration ◽  
Theoretical Treatment ◽  
Free Metal

A method introduced by R. Osterberg for the measurement of free ligand concentration during the formation of metal complexes has recently been extended by Sarkar and Kruck to include measurement of free metal concentration. The method is based on suitable manipulation of the data from sets of pH titrations. This paper gives a new theoretical treatment of the method and its extension, and shows how the functions developed are related to other parameters of complex formation. A special advantage of Osterberg's method as extended is its capability of being applied when protonated or deprotonated complexes form.

scholarly journals Copper (II) Complex of Salicylaldehyde Semicarbazone: Synthesis, Characterization and Antibacterial Activity

2019 ◽  
pp. 1-8
Author(s):  
Dipta Sarker ◽  
Md. Rabiul Karim ◽  
Md. Masuqul Haque ◽  
Rausan Zamir ◽  
Md. Ali Asraf
Keyword(s):  
Experimental Data ◽  
Antibacterial Activity ◽  
Metal Complex ◽  
Copper Atom ◽  
Free Ligand ◽  
Enterobacter Aerogenes ◽  
Planar Geometry ◽  
Square Planar ◽  
Physicochemical Methods ◽  
Fourth Position

Salicylaldehyde semicarbazone ligand and its Cu (II) complex have been synthesized and characterized by a range of physicochemical methods. Experimental data shows the complex is monomeric and the copper atom is four coordinated in a square planar geometry. The ligand chelates the copper in a tridentate fashion through the carbonyl O,  imine N, and phenolato O with the fourth position being occupied by coordinated Cl. Antibacterial activity of the  prepared compounds was tested against the microbes Enterobacter Aerogenes and Bacillus Cereus. The metal complex showed higher antibacterial activity than the free ligand.

Metal-Complex Ions in Hydrocarbons

1957 ◽  
Vol 12 (1_2) ◽  
pp. 96-109 ◽  
Author(s):  
Andrew Gemant
Keyword(s):  
Metal Complex ◽  
Complex Ions

Exogenous Directing Group Free, Ligand-Enabled gamma-C(sp3)–H Arylation of Free Primary Aliphatic Amines and α-Amino Esters

2019 ◽  
Author(s):  
Yongzheng Ding ◽  
Shuai Fan ◽  
Xiaoxi Chen ◽  
yuzhen gao ◽  
Gang Li
Keyword(s):  
Amino Acids ◽  
Large Scale ◽  
Free Ligand ◽  
Aliphatic Amines ◽  
Rapid Synthesis ◽  
Amino Esters ◽  
Directing Group ◽  
Large Scale Synthesis ◽  
Primary Aliphatic Amines

A Pdᴵᴵ-catalyzed, ligand-enabled gamma-C(sp3)–H arylation of free primary aliphatic amines and amino esters without using an exogenous directing group is reported. This reaction is compatible with unhindered free aliphatic amines, and it is also be applicable to the rapid synthesis of biologically and synthetically valuable unnatural α-amino acids. Large scale synthesis is also feasible using this method.<br>

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