On An Extension of the Use of pH-Titrations for Determination of Free Metal and Free Ligand Concentrations During Metal Complex Formation

1973 ◽  
Vol 51 (21) ◽  
pp. 3572-3576 ◽  
Author(s):  
W. A. E. McBryde
Keyword(s):  
Complex Formation ◽  
Metal Complex ◽  
Metal Complexes ◽  
Metal Concentration ◽  
Free Ligand ◽  
Ligand Concentration ◽  
Theoretical Treatment ◽  
Free Metal

A method introduced by R. Osterberg for the measurement of free ligand concentration during the formation of metal complexes has recently been extended by Sarkar and Kruck to include measurement of free metal concentration. The method is based on suitable manipulation of the data from sets of pH titrations. This paper gives a new theoretical treatment of the method and its extension, and shows how the functions developed are related to other parameters of complex formation. A special advantage of Osterberg's method as extended is its capability of being applied when protonated or deprotonated complexes form.

1,1'-Bis(alkylarylphosphino)ferrocenes: synthesis, metal complex formation, and crystal structure of three metal complexes of Fe(.eta.5-C5H4PPh2)2

1985 ◽  
Vol 4 (6) ◽  
pp. 972-980 ◽  
Author(s):  
Ian R. Butler ◽  
William R. Cullen ◽  
Tae Jeong. Kim ◽  
Steven J. Rettig ◽  
James. Trotter
Keyword(s):  
Crystal Structure ◽  
Complex Formation ◽  
Metal Complex ◽  
Metal Complexes

Protocols for use of ultrafiltration in determination of free ligand concentration and of complexity of ligand/protein interactions.

1987 ◽  
Vol 33 (1) ◽  
pp. 115-117 ◽  
Author(s):  
G K Wolfer ◽  
W B Rippon
Keyword(s):  
Protein Interactions ◽  
Free Ligand ◽  
Interaction Model ◽  
Original Data ◽  
Ligand Concentration ◽  
Association Model ◽  
Filtration Time ◽  
Binding Data ◽  
Complex Ligand

Abstract Analysis of a simple ligand/binding-protein association model predicts a decrease in the percentage of free hormone during ultrafiltration. Re-analysis of the original data validating ultrafiltration in free-ligand determinations (Sophianopoulos et al., Arch Biochem Biophys 1978;187:132-7) confirms this prediction. Binding data indicating a constant percentage of free hormone (Hammond et al., J Biol Chem 1980;255;5023-6) require a more complex ligand-protein interaction model. Application of these procedures to any new ligand system requires measurement of the percentage free, or of free-ligand concentration, as a function of filtration time or volume. The protocol becomes important if values for percentage free are to be accurate.

scholarly journals Theoretical Study and Biological Activity of Co(II), Ni(II), Cu(II),Pd(II),Pt(IV) and Cd(II) Complexes with2-Thioxoimidazolidin-4-one Derivative

2018 ◽  
Vol 28 (2) ◽  
pp. 64
Author(s):  
Sallal A. H. Abdullah
Keyword(s):  
Metal Complexes ◽  
Gas Phase ◽  
Theoretical Study ◽  
Free Ligand ◽  
Heat Of Formation ◽  
Theoretical Treatment ◽  
Great Activity ◽  
Minimal Inhibitory Concen ◽  
Micro Organisms ◽  
New Compounds

The workcontains a theoretical treatment of the preparedligand(3-{[(Z)-(4-nitrophenyl) methyli -dene]amino}-2-thioxoimidazolidin-4-one)[L] and their metal complexes[S1-S6]in the gas phase. Hyperchem-8 program has been used to determined structural geometries of ligand and their met-al complexes. The electrostatic potential(Ep)of the ligand was calculated,furthermore binding en-ergy(ΔEb),the heat of formation(ΔHf),vibration spectra and bond length for the ligand and their metal co -mplexes were calculated by PM3methods at 298K°. The theoretically calculateddata were agreed with those found experimentally. The antibacterial activity for free ligand and its metal complexes(S1-S6)were studied against two selected micro-organisms [(Staphylococcusau-reus) as gram positive]and [(Escherichiacoli)as gram negative]. The minimal inhibitory concen-trations(MIC)have been also studied to determine the low concentration for inhibition. The anti-biotics (Amoxcillin and Ampicillin) have been chosen to compare their activity with those of the new compounds. Furthermore the antif -ungal activity against two microorganisms (Candidaalbi-cans) and (Aspergillusflavus) were studied for all compounds. The results showed great activity of the complexes relative to that of free ligand.

scholarly journals Direct determination of free metal concentration by implementing stripping chronopotentiometry as the second stage of AGNES

The Analyst ◽  
2011 ◽  
Vol 136 (20) ◽  
pp. 4337 ◽  
Author(s):  
C. Parat ◽  
L. Authier ◽  
D. Aguilar ◽  
E. Companys ◽  
J. Puy ◽  
...  
Keyword(s):  
Metal Concentration ◽  
Direct Determination ◽  
Second Stage ◽  
Stripping Chronopotentiometry ◽  
Free Metal

Colorimetric Determination of Fluoride in Drinking Groundwater using a Polymeric Zirconium Complex of 5-(2-Carboxyphenylazo)-8-Hydroxyquinoline

2013 ◽  
Vol 12 (7) ◽  
pp. 460-465
Author(s):  
Sameer Amereih ◽  
Zaher Barghouthi ◽  
Lamees Majjiad
Keyword(s):  
Drinking Water ◽  
Detection Limit ◽  
Complex Formation ◽  
Molar Absorptivity ◽  
Colorimetric Determination ◽  
Zirconium Complex ◽  
Reliable Determination ◽  
Percentage Recovery ◽  
Quantitation Limit

A sensitive colorimetric determination of fluoride in drinking water has been developed using a polymeric zirconium complex of 5-(2-Carboxyphenylazo)-8-Hydroxyquinoline as fluoride reagents. The method allowed a reliable determination of fluoride in range of (0.0-1.5) mg L-1. The molar absorptivity of the complex formation is 7695 ± 27 L mol-1 cm-1 at 460 nm. The sensitivity, detection limit, quantitation limit, and percentage recovery for 1.0 mg L-1 fluoride for the proposed method were found to be 0.353 ± 0.013 μg mL-1, 0.1 mg L-1, 0.3 mg L-1, and 101.7 ± 4.1, respectively.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

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