New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

2017 ◽  
Vol 53 (58) ◽  
pp. 8184-8187 ◽  
Author(s):  
Parikshit Moitra ◽  
Krishan Kumar ◽  
Sourav Sarkar ◽  
Paturu Kondaiah ◽  
Wei Duan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ph Sensitive ◽  
Liposomal Formulation ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Doxorubicin Delivery

A new pH-sensitive co-liposomal formulation was developed which could efficiently transport doxorubicin across the DOX-resistant cancer cells.

scholarly journals Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

2021 ◽  
Vol 9 ◽  
Author(s):  
Enping Chen ◽  
Ting Wang ◽  
Junmei Zhang ◽  
Xiang Zhou ◽  
Yafan Niu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Combination Regimen ◽  
Drug Efflux ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Chemotherapeutic Drug ◽  
Mitochondrial Targeting ◽  
Ph Responsive ◽  
Mcf 7

Multidrug resistance (MDR) is one of the leading causes of the failure of cancer chemotherapy and mainly attributed to the overexpression of drug efflux transporters in cancer cells, which is dependent on adenosine triphosphate (ATP). To overcome this phenomenon, herein, a mitochondrial-directed pH-sensitive polyvinyl alcohol (PVA) nanogel incorporating the hexokinase inhibitor lonidamine (LND) and the chemotherapeutic drug paclitaxel (PTX) was developed to restore the activity of PTX and synergistically treat drug-resistant tumors. The introduction of 2-dimethylaminoethanethiol (DMA) moiety into the nanogels not only promoted the drug loading capacity but also enabled the lysosomal escape of the nanogels. The subsequent mitochondrial targeting facilitated the accumulation and acid-triggered payload release in the mitochondria. The released LND can destroy the mitochondria by exhausting the mitochondrial membrane potential (MMP), generating reactive oxygen species (ROS) and restraining the energy supply, resulting in apoptosis and susceptibility of the MCF-7/MDR cells to PTX. Hence, the nanogel-enabled combination regimen of LND and PTX showed a boosted anti-tumor efficacy in MCF-7/MDR cells. These mitochondrial-directed pH-sensitive PVA nanogels incorporating both PTX and LND represent a new nanoplatform for MDR reversal and enhanced therapeutic efficacy.

scholarly journals Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells

2015 ◽  
pp. 5249 ◽  
Author(s):  
Jong Oh Kim ◽  
Tuan Hiep Tran ◽  
Thiruganesh Ramasamy ◽  
Ju Yeon Choi ◽  
Hanh Nguyen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Targeting ◽  
Ph Sensitive ◽  
Drug Resistant

Novel pH-responsive dextrin nanogels for doxorubicin delivery to cancer cells with reduced cytotoxicity to cardiomyocytes and stem cells

2014 ◽  
Vol 114 ◽  
pp. 78-86 ◽  
Author(s):  
Somkamol Manchun ◽  
Kamonrak Cheewatanakornkool ◽  
Crispin R. Dass ◽  
Pornsak Sriamornsak
Keyword(s):  
Stem Cells ◽  
Cancer Cells ◽  
Ph Responsive ◽  
Doxorubicin Delivery

pH-Responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin into tumor cells

Nanoscale ◽  
2017 ◽  
Vol 9 (34) ◽  
pp. 12533-12542 ◽  
Author(s):  
Cheng Gao ◽  
Fan Tang ◽  
Guiyi Gong ◽  
Jianxiang Zhang ◽  
Maggie P. M. Hoi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Sodium Alginate ◽  
Safety Profile ◽  
Ph Sensitive ◽  
Efficacy And Safety ◽  
Ph Responsive

A pH-sensitive prodrug nanoparticle demonstrated the selective co-delivery of doxorubicin and curcumin into cancer cells with much improved efficacy and safety profile.

scholarly journals Natural tripeptide capped pH-sensitive gold nanoparticles for efficacious doxorubicin delivery both in vitro and in vivo

Nanoscale ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 1067-1074 ◽  
Author(s):  
Krishan Kumar ◽  
Parikshit Moitra ◽  
Mohsin Bashir ◽  
Paturu Kondaiah ◽  
Santanu Bhattacharya
Keyword(s):  
Gold Nanoparticles ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Ph Sensitive ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Line P

AuNPs capped with a natural pH-responsive short tripeptide sequence are presented herein for the successful delivery of doxorubicin both in vitro and in vivo. Efficacy of the system has also been evaluated in drug resistant cancer cell line.

scholarly journals WITHDRAWN: Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells

2015 ◽  
Author(s):  
Jin Wook Tak ◽  
Tran Thuan Hiep ◽  
Pham Thanh Tung ◽  
Bijay Kumar Poudel ◽  
Kyu bong Woo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Targeting ◽  
Ph Sensitive ◽  
Drug Resistant

pH-responsive selenium nanoparticles stabilized by folate-chitosan delivering doxorubicin for overcoming drug-resistant cancer cells

2018 ◽  
Vol 181 ◽  
pp. 841-850 ◽  
Author(s):  
Urarika Luesakul ◽  
Songchan Puthong ◽  
Nouri Neamati ◽  
Nongnuj Muangsin
Keyword(s):  
Cancer Cells ◽  
Selenium Nanoparticles ◽  
Drug Resistant ◽  
Ph Responsive

scholarly journals Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (47) ◽  
pp. 29164-29177
Author(s):  
Zainab Lafi ◽  
Walhan Alshaer ◽  
Ma'mon M. Hatmal ◽  
Malek Zihlif ◽  
Dana A. Alqudah ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Selective Targeting ◽  
Selective Delivery

Echinomycin was loaded into PEGylated pH-sensitive liposomes and functionalized with anti-nucleolin aptamer for selective targeting and pH-responsive release of echinomycin into cancer cells.

Reversion of multidrug resistance by a pH-responsive cyclodextrin-derived nanomedicine in drug resistant cancer cells

Biomaterials ◽  
2015 ◽  
Vol 67 ◽  
pp. 169-182 ◽  
Author(s):  
Qing Shi ◽  
Lin Zhang ◽  
Mengyu Liu ◽  
Xuelin Zhang ◽  
Xiangjun Zhang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Drug Resistant ◽  
Ph Responsive
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