scholarly journals Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells

2015 ◽  
pp. 5249 ◽  
Author(s):  
Jong Oh Kim ◽  
Tuan Hiep Tran ◽  
Thiruganesh Ramasamy ◽  
Ju Yeon Choi ◽  
Hanh Nguyen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Targeting ◽  
Ph Sensitive ◽  
Drug Resistant

scholarly journals WITHDRAWN: Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells

2015 ◽  
Author(s):  
Jin Wook Tak ◽  
Tran Thuan Hiep ◽  
Pham Thanh Tung ◽  
Bijay Kumar Poudel ◽  
Kyu bong Woo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Targeting ◽  
Ph Sensitive ◽  
Drug Resistant

scholarly journals Enhancement of radiation effect on cancer cells by gold-pHLIP

2015 ◽  
Vol 112 (17) ◽  
pp. 5372-5376 ◽  
Author(s):  
Michael P. Antosh ◽  
Dayanjali D. Wijesinghe ◽  
Samana Shrestha ◽  
Robert Lanou ◽  
Yun Hu Huang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Adverse Effects ◽  
Cell Survival ◽  
Cancer Cells ◽  
Tumor Targeting ◽  
Radiation Effect ◽  
Ph Sensitive ◽  
Radiation Doses ◽  
Preclinical Evaluation ◽  
Auger Effect

Previous research has shown that gold nanoparticles can increase the effectiveness of radiation on cancer cells. Improved radiation effectiveness would allow lower radiation doses given to patients, reducing adverse effects; alternatively, it would provide more cancer killing at current radiation doses. Damage from radiation and gold nanoparticles depends in part on the Auger effect, which is very localized; thus, it is important to place the gold nanoparticles on or in the cancer cells. In this work, we use the pH-sensitive, tumor-targeting agent, pH Low-Insertion Peptide (pHLIP), to tether 1.4-nm gold nanoparticles to cancer cells. We find that the conjugation of pHLIP to gold nanoparticles increases gold uptake in cells compared with gold nanoparticles without pHLIP, with the nanoparticles distributed mostly on the cellular membranes. We further find that gold nanoparticles conjugated to pHLIP produce a statistically significant decrease in cell survival with radiation compared with cells without gold nanoparticles and cells with gold alone. In the context of our previous findings demonstrating efficient pHLIP-mediated delivery of gold nanoparticles to tumors, the obtained results serve as a foundation for further preclinical evaluation of dose enhancement.

New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

2017 ◽  
Vol 53 (58) ◽  
pp. 8184-8187 ◽  
Author(s):  
Parikshit Moitra ◽  
Krishan Kumar ◽  
Sourav Sarkar ◽  
Paturu Kondaiah ◽  
Wei Duan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ph Sensitive ◽  
Liposomal Formulation ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Doxorubicin Delivery

A new pH-sensitive co-liposomal formulation was developed which could efficiently transport doxorubicin across the DOX-resistant cancer cells.

scholarly journals Instructed‐assembly of small peptides inhibits drug‐resistant prostate cancer cells

2019 ◽  
Vol 112 (1) ◽  
Author(s):  
Zhaoqianqi Feng ◽  
Huaimin Wang ◽  
Meihui Yi ◽  
Chieh‐Yun Lo ◽  
Ashanti Sallee ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Drug Resistant ◽  
Prostate Cancer Cells ◽  
Small Peptides

Silencing PEX26 as an Unconventional Mode to Kill Drug-Resistant Cancer Cells and Forestall Drug Resistance

Autophagy ◽  
2021 ◽  
Author(s):  
Michael S. Dahabieh ◽  
Fan Huang ◽  
Christophe Goncalves ◽  
Raúl Ernesto Flores González ◽  
Sathyen Prabhu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Drug Resistant

LDH-doped electrospun short fibers enable dual drug loading and multistage release for chemotherapy of drug-resistant cancer cells

2021 ◽  
Author(s):  
Yupei Ma ◽  
Du Li ◽  
Yunchao Xiao ◽  
Zhijun OuYang ◽  
Mingwu Shen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Cancer Chemotherapy ◽  
Side Effect ◽  
Drug Loading ◽  
Adverse Side Effect ◽  
Drug Resistant ◽  
Short Fibers ◽  
Dual Drug

Conventional cancer chemotherapy is facing difficulties in improving the bioavailability, overcoming the severe adverse side effect of chemotherapeutics and reversing the multidrug resistance of cancer cells. To address these challenges,...

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