pH-Responsive prodrug nanoparticles based on a sodium alginate derivative for selective co-release of doxorubicin and curcumin into tumor cells

Nanoscale ◽  
2017 ◽  
Vol 9 (34) ◽  
pp. 12533-12542 ◽  
Author(s):  
Cheng Gao ◽  
Fan Tang ◽  
Guiyi Gong ◽  
Jianxiang Zhang ◽  
Maggie P. M. Hoi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Sodium Alginate ◽  
Safety Profile ◽  
Ph Sensitive ◽  
Efficacy And Safety ◽  
Ph Responsive

A pH-sensitive prodrug nanoparticle demonstrated the selective co-delivery of doxorubicin and curcumin into cancer cells with much improved efficacy and safety profile.

Glutathione-responsive nanoparticles based on a sodium alginate derivative for selective release of doxorubicin in tumor cells

2017 ◽  
Vol 5 (12) ◽  
pp. 2337-2346 ◽  
Author(s):  
Cheng Gao ◽  
Fan Tang ◽  
Jianxiang Zhang ◽  
Simon M. Y. Lee ◽  
Ruibing Wang
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Sodium Alginate ◽  
Safety Profile

GSH-responsive nanoparticles based on disulfide crosslinked amphiphilic alginate demonstrated selected drug release in cancer cells with a much improved safety profile.

scholarly journals Galactose-Modified PH-Sensitive Niosomes for Controlled Release and Hepatocellular Carcinoma Target Delivery of Tanshinone IIA

2021 ◽  
Vol 22 (3) ◽  
Author(s):  
Xixi Hu ◽  
Jun Zhang ◽  
Lulu Deng ◽  
Hao Hu ◽  
Junjie Hu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Hepatoma Cell ◽  
Ph Sensitive ◽  
Tanshinone Iia ◽  
Ovarian Cancer Cells ◽  
Ionic Surfactant ◽  
Liver Targeting ◽  
Targeting Ability

AbstractIncreasing the drug tumor-specific accumulation and controlling their release is considered one of the most effective ways to increase the efficacy of drugs. Here, we developed a vesicle system that can target hepatoma and release drugs rapidly within tumor cells. This non-ionic surfactant vesicle is biodegradable. Galactosylated stearate has been used to glycosylate the vesicles to achieve liver targeting; replacement of a portion (Chol:CHEMS = 1:1) of cholesterol by cholesteryl hemisuccinate (CHEMS) allows for a rapid release of drugs in an acidic environment. In vitro release experiments confirmed that galactose-modified pH-sensitive niosomes loaded with tanshinone IIA had excellent drug release performance in acid medium. In vitro experiments using ovarian cancer cells (A2780), colon cancer cells (HCT8), and hepatoma cell (Huh7, HepG2) confirmed that the preparation had specific targeting ability to hepatoma cells compared with free drugs, and this ability was dependent on the galactose content. Furthermore, the preparation also had a more substantial inhibitory effect on tumor cells, and subsequent apoptosis assays and cell cycle analyses further confirmed its enhanced anti-tumor effect. Results of pharmacokinetic experiments confirmed that the vesicle system could significantly extend the blood circulation time of tanshinone IIA, and the larger area under the curve indicated that the preparation had a better drug effect. Thus, the results of biodistribution experiments confirmed the in vivo liver targeting ability of this preparation. Niosomes designed in this manner are expected to be a safe and effective drug delivery system for liver cancer therapy.

Fabrication and characterization of biocompatible pH responsive halloysite nanotubes grafted with sodium alginate for sustained release of phenytoin sodium

2019 ◽  
Vol 43 (26) ◽  
pp. 10523-10530 ◽  
Author(s):  
Leila Zeraatpishe ◽  
Alireza Mohebali ◽  
Majid Abdouss
Keyword(s):  
Controlled Release ◽  
Sustained Release ◽  
Sodium Alginate ◽  
Halloysite Nanotubes ◽  
Ph Sensitive ◽  
New Method ◽  
Ph Responsive ◽  
Phenytoin Sodium ◽  
Fabrication And Characterization

Schematic design of a new method for fabrication of biocompatible pH sensitive halloysite nanocomposites for controlled release of phenytoin sodium.

New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

2017 ◽  
Vol 53 (58) ◽  
pp. 8184-8187 ◽  
Author(s):  
Parikshit Moitra ◽  
Krishan Kumar ◽  
Sourav Sarkar ◽  
Paturu Kondaiah ◽  
Wei Duan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ph Sensitive ◽  
Liposomal Formulation ◽  
Drug Resistant ◽  
Ph Responsive ◽  
Doxorubicin Delivery

A new pH-sensitive co-liposomal formulation was developed which could efficiently transport doxorubicin across the DOX-resistant cancer cells.

Synthesis and characterization of temperature/pH-sensitive hydroxypropylcellulose/ sodium alginate hydrogel

e-Polymers ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Hui Li ◽  
Guo-li Gong
Keyword(s):  
Sodium Alginate ◽  
Ph Value ◽  
Ph Sensitive ◽  
Swelling Ratio ◽  
Ph Responsive ◽  
Alginate Hydrogel ◽  
Sensitive Material ◽  
Maximum Value ◽  
Responsive Hydrogels

AbstractA series of temperature and pH responsive hydrogels were synthesized by using hydroxypropylcellulose (HPC) as temperature natural sensitive material, sodium alginate (SA) as pH sensitive material. The effect of SA to LCST has been studied and the mechanism of the influence has been presented. In addition, the swelling ratio and controlling factor of swelling process were all researched in this paper. The main results obtained are as follows: the LCST decreased gradually as SA was added into HPC; the HPC/SA hydrogel responded to both temperature and pH value of the medium; the swelling ratio reached maximum value at pH value of 6.

Multi pH-sensitive polymer–drug conjugate mixed micelles for efficient co-delivery of doxorubicin and curcumin to synergistically suppress tumor metastasis

2020 ◽  
Vol 8 (18) ◽  
pp. 5029-5046 ◽  
Author(s):  
Yuanhang Zhou ◽  
Chuhang Zhou ◽  
Yang Zou ◽  
Yao Jin ◽  
Shidi Han ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Tumor Metastasis ◽  
Mixed Micelles ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Drug Conjugate ◽  
Responsive Polymer ◽  
Ph Sensitive Polymer

Multi pH-responsive polymer-drug conjugate mixed micelles were fabricated to co-deliver doxorubicin and curcumin for synergistic suppression tumor metastasis via inhibiting the invasion, migration, intravasation and extravasation of tumor cells.

scholarly journals Aptamer-functionalized pH-sensitive liposomes for a selective delivery of echinomycin into cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (47) ◽  
pp. 29164-29177
Author(s):  
Zainab Lafi ◽  
Walhan Alshaer ◽  
Ma'mon M. Hatmal ◽  
Malek Zihlif ◽  
Dana A. Alqudah ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Selective Targeting ◽  
Selective Delivery

Echinomycin was loaded into PEGylated pH-sensitive liposomes and functionalized with anti-nucleolin aptamer for selective targeting and pH-responsive release of echinomycin into cancer cells.

Role of exosomes in diagnosis and therapy of prostate cancer

2020 ◽  
Vol 28 (3) ◽  
pp. 399-405
Author(s):  
Fabrizio Fontana ◽  
Olga A. Babenko
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Biological Fluids ◽  
Diagnosis And Treatment ◽  
Diagnosis And Therapy ◽  
The Future ◽  
Important Direction ◽  
Potential Biomarkers

Aim of this letter is to attract the attention of journal readers to the study of exosomes as an important direction in the development of Oncology, in particular, in the diagnosis and treatment of prostate cancer. Exosomes are produced by tumor cells and regulate proliferation, metastasis, and the development of chemoresistance. Their extraction from biological fluids allows further use of these vesicles as potential biomarkers of prostate cancer. In the future, exosomes can be successfully used in the delivery of drugs and other anti-tumor substances to cancer cells.

Sign in / Sign up

Export Citation Format

Share Document