A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

2017 ◽  
Vol 53 (21) ◽  
pp. 3126-3129 ◽  
Author(s):  
Leilei Rui ◽  
Yudong Xue ◽  
Yong Wang ◽  
Yun Gao ◽  
Weian Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Inclusion Complex ◽  
Mitochondria Targeting

A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host–guest inclusion complex.

A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

2019 ◽  
Vol 55 (83) ◽  
pp. 12547-12550 ◽  
Author(s):  
Cheng Zhang ◽  
Ruilin Guan ◽  
Xinxing Liao ◽  
Cheng Ouyang ◽  
Thomas W. Rees ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Binuclear Complex ◽  
Tumour Cells ◽  
Ru Complex ◽  
Mitochondria Targeting

A mitochondria-targeting hetero-binuclear complex (Ir–Ru) was developed for the synergistic photoactivated chemotherapy and photodynamic therapy of cisplatin-resistant tumour cells.

Highly Selective Mitochondria-Targeting Amphiphilic Silicon(IV) Phthalocyanines with Axially Ligated Rhodamine B for Photodynamic Therapy

2011 ◽  
Vol 51 (2) ◽  
pp. 812-821 ◽  
Author(s):  
Zhixin Zhao ◽  
Pui-Shan Chan ◽  
Hongguang Li ◽  
Ka-Leung Wong ◽  
Ricky Ngok Shun Wong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rhodamine B ◽  
Mitochondria Targeting

Photo-induced crystallization with emission enhancement (PICEE)

2020 ◽  
Vol 7 (11) ◽  
pp. 3005-3010
Author(s):  
Kongqi Chen ◽  
Rongyuan Zhang ◽  
Ganggang Li ◽  
Baoxi Li ◽  
Yao Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Emission Enhancement ◽  
Isoquinolinium Salt ◽  
Mitochondria Targeting ◽  
Induced Crystallization

A new photoactivation mechanism, photo-induced crystallization with emission enhancement, is developed based on an isoquinolinium salt with applications in mitochondria-targeting and photodynamic therapy.

Mitochondria-Targeting Polyamine-Protoporphyrin Conjugates for Photodynamic Therapy

ChemMedChem ◽  
2017 ◽  
Vol 13 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Fargol Taba ◽  
Akira Onoda ◽  
Urara Hasegawa ◽  
Toshiaki Enoki ◽  
Yousuke Ooyama ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mitochondria Targeting

scholarly journals Front Cover: Mitochondria-Targeting Polyamine-Protoporphyrin Conjugates for Photodynamic Therapy (ChemMedChem 1/2018)

ChemMedChem ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. 1-1 ◽  
Author(s):  
Fargol Taba ◽  
Akira Onoda ◽  
Urara Hasegawa ◽  
Toshiaki Enoki ◽  
Yousuke Ooyama ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Front Cover ◽  
Mitochondria Targeting

scholarly journals Multifunctional AIE iridium (III) photosensitizer nanoparticles for two-photon-activated imaging and mitochondria targeting photodynamic therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xuzi Cai ◽  
Kang-Nan Wang ◽  
Wen Ma ◽  
Yuanyuan Yang ◽  
Gui Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Solubility ◽  
Tissue Imaging ◽  
Ros Generation ◽  
Generation Efficiency ◽  
Deep Tissue ◽  
Two Photon ◽  
Mitochondria Targeting

AbstractDeveloping novel photosensitizers for deep tissue imaging and efficient photodynamic therapy (PDT) remains a challenge because of the poor water solubility, low reactive oxygen species (ROS) generation efficiency, serve dark cytotoxicity, and weak absorption in the NIR region of conventional photosensitizers. Herein, cyclometalated iridium (III) complexes (Ir) with aggregation-induced emission (AIE) feature, high photoinduced ROS generation efficiency, two-photon excitation, and mitochondria-targeting capability were designed and further encapsulated into biocompatible nanoparticles (NPs). The Ir-NPs can be used to disturb redox homeostasis in vitro, result in mitochondrial dysfunction and cell apoptosis. Importantly, in vivo experiments demonstrated that the Ir-NPs presented obviously tumor-targeting ability, excellent antitumor effect, and low systematic dark-toxicity. Moreover, the Ir-NPs could serve as a two-photon imaging agent for deep tissue bioimaging with a penetration depth of up to 300 μm. This work presents a promising strategy for designing a clinical application of multifunctional Ir-NPs toward bioimaging and PDT.

Sign in / Sign up

Export Citation Format

Share Document