A mitochondria-targeting dinuclear Ir–Ru complex as a synergistic photoactivated chemotherapy and photodynamic therapy agent against cisplatin-resistant tumour cells

2019 ◽  
Vol 55 (83) ◽  
pp. 12547-12550 ◽  
Author(s):  
Cheng Zhang ◽  
Ruilin Guan ◽  
Xinxing Liao ◽  
Cheng Ouyang ◽  
Thomas W. Rees ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Binuclear Complex ◽  
Tumour Cells ◽  
Ru Complex ◽  
Mitochondria Targeting

A mitochondria-targeting hetero-binuclear complex (Ir–Ru) was developed for the synergistic photoactivated chemotherapy and photodynamic therapy of cisplatin-resistant tumour cells.

scholarly journals Developing Carrier Complexes for “Caged NO”: RuCl3(NO)(H2O)2 Complexes of Dipyridylamine, (dpaH), N,N,N'N'-Tetrakis (2-Pyridyl) Adipamide, (tpada), and (2-Pyridylmethyl) Iminodiacetate, (pida2-)

2000 ◽  
Vol 7 (2) ◽  
pp. 67-75 ◽  
Author(s):  
Joseph M. Slocik ◽  
Richard A. Kortes ◽  
Rex E. Shepherd
Keyword(s):  
Photodynamic Therapy ◽  
Binuclear Complex ◽  
Structural Information ◽  
Infrared Methods ◽  
Related Complex

Delivery agents which can carry the {Ru(NO)}6 chromophore (“caged NO”) are desired for vasodilation and for photodynamic therapy of tumors. Toward these goals, complexes derived from [RuCl3(NO)(H2O)2]= (1) have been prepared using dipyridylamine (dpaH) as mono and bis adducts, [Ru(NO)Cl3(dpaH)] = (2) and [Ru(NO)Cl(dpaH)2]Cl2 = (3). The dpaH ligands coordinate cis to the Ru(NO) axis.The mono derivative is a model for a potential DNA groove-spanning binuclear complex {[Ru(NO)Cl3]2(tpada)} = (4) which has two DNA-coordinating RuII centers, photo-labile {Ru(NO)}6 sites, and a groove-spanning tether moiety.The binuclear assembly is prepared from the tethered dipyridylamine ligand N,N,N',N'-tetrakis(2-pyridylmethyl)adipamide (tpada) which has recently been shown to provide a binuclear carrier complex suited to transporting RuII and PdII agents. A related complex, [Ru(NO)Cl(pida)] = (5) with the {Ru(NO)}6 moiety bound to (2-pyridylmethyl) iminodiacetate (pida2-) is also characterized as a potential “caged NO” carrier. Structural information concerning the placement of the pyridyl donor groups relative to the {Ru(NO)}6 unit has been obtained from H1 and C13 NMR and infrared methods, noting that a pyridyl donor trans to NO+ causes “trans strengthening” of this ligand for [Ru(NO)Cl(pida)], whereas placement of pyridyl groups cis to NO+ causes a weakening of the N-O bond and a lower NO stretching frequency in the dpa-based complexes.

Taurine-modified Ru(ii)-complex targets cancerous brain cells for photodynamic therapy

2017 ◽  
Vol 53 (44) ◽  
pp. 6033-6036 ◽  
Author(s):  
Enming Du ◽  
Xunwu Hu ◽  
Sona Roy ◽  
Peng Wang ◽  
Kieran Deasy ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Cancer Cells ◽  
Water Solubility ◽  
Brain Cells ◽  
Independent Manner ◽  
Ru Complex

Symmetrical taurine modification not only enhances the intracellular affinity of a polypyridyl Ru-complex to cancer cells, but also boosts the quantum yield in a pH-independent manner without sacrificing water solubility for cytosolic photosensitizers of photodynamic therapy, with prominent efficacy in cancerous brain cells.

scholarly journals Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy

2017 ◽  
Vol 8 (5) ◽  
pp. 3891-3897 ◽  
Author(s):  
Yong-Mei Wang ◽  
Wei Liu ◽  
Xue-Bo Yin
Keyword(s):  
Computed Tomography ◽  
Photodynamic Therapy ◽  
Magnetic Resonance ◽  
Coordination Polymers ◽  
X Ray ◽  
Mixed Metal ◽  
Ru Complex ◽  
X Ray Computed ◽  
Nanoscale Coordination Polymers

Multifunctional mixed-metal nanoscale coordination polymers (NCPs) are robustly prepared with a Ru complex, Gd3+, and Yb3+. The NCPs were used as fluorescence, magnetic resonance, and X-ray computed tomography triple-modality imaging and imaging-guided photodynamic therapy.

Highly Selective Mitochondria-Targeting Amphiphilic Silicon(IV) Phthalocyanines with Axially Ligated Rhodamine B for Photodynamic Therapy

2011 ◽  
Vol 51 (2) ◽  
pp. 812-821 ◽  
Author(s):  
Zhixin Zhao ◽  
Pui-Shan Chan ◽  
Hongguang Li ◽  
Ka-Leung Wong ◽  
Ricky Ngok Shun Wong ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Rhodamine B ◽  
Mitochondria Targeting

Photo-induced crystallization with emission enhancement (PICEE)

2020 ◽  
Vol 7 (11) ◽  
pp. 3005-3010
Author(s):  
Kongqi Chen ◽  
Rongyuan Zhang ◽  
Ganggang Li ◽  
Baoxi Li ◽  
Yao Ma ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Emission Enhancement ◽  
Isoquinolinium Salt ◽  
Mitochondria Targeting ◽  
Induced Crystallization

A new photoactivation mechanism, photo-induced crystallization with emission enhancement, is developed based on an isoquinolinium salt with applications in mitochondria-targeting and photodynamic therapy.

Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted 1- and 2-Photon Photodynamic Therapy

2020 ◽  
Author(s):  
Johannes Karges ◽  
Jia Li ◽  
Leli Zeng ◽  
Hui Chao ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cell ◽  
Polymeric Nanoparticles ◽  
Multicellular Tumor Spheroid ◽  
Epithelial Tumor ◽  
Ru Complex ◽  
Cell Selectivity ◽  
Polypyridine Complexes ◽  
Ruthenium Polypyridine

Photodynamic therapy is a medical technique, which is gaining increasing attention to treat various types of cancer. Among the investigated classes of photosensitizers, the use of Ru(II) polypyridine complexes is gaining momentum. However, the currently investigated compounds generally show poor cancer cell selectivity. As a consequence, high drug doses are needed, which can cause side effects. To overcome this limitation, there is a need for the development of a suitable drug delivery system to increase the amount of PS delivered to the tumor. Herein, we report on the encapsulation of a promising Ru(II) polypyridyl complex into polymeric nanoparticles with terminal biotin groups. Thanks to this design, the particles showed much higher selectivity for cancer cells in comparison to non-cancerous cells in a 2D monolayer and 3D multicellular tumor spheroid model. As a highlight, upon intravenous injection of an identical amount of the Ru(II) polypyridine complex, an improved accumulation inside an adenocarcinomic human alveolar basal epithelial tumor of a mouse by a factor of 8.7 compared to the Ru complex itself was determined. The nanoparticles were found to have a high phototoxic effect upon 1-photon (500 nm) or 2-photon (800 nm) excitation with an eradication of an adenocarcinomic human alveolar basal epithelial tumor inside a mouse. Overall, this work describes, to the best of our knowledge, the first <i>in vivo</i> study demonstrating the cancer cell selectivity of a very promising Ru(II)-based PDT photosensitizer encapsulated into polymeric nanoparticles with terminal biotin groups.

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