Background:
Cancer is a condition in which some cells in the body grow uncontrollably
and can also spread in other parts of the body. Among males, oral and lung cancers account
for 25 % cancer deaths, while in females, breast and oral cancers cause 25% death. Breast and
cervical cancers are the underlying cause of the high mortality rate among women. Owing to limitations
of conventional cancer therapy like low drug specificity, less solubility, multidrug resistance,
poor access to tumor cells and low bioavailability development of environmentally sensitive
and target specific nanocarriers are imperative.
Objective:
The objective of this study is to review advancements made in techniques to synthesize
Mesoporous Silica Nanoparticles (MSN’s) as well as strategies to functionalize its silanol group
for site-specific drug release in the tumor environment and to review recent patents published regarding
it. To describe rationale for selection of MSN’s for cancer theranostics amidst other nanocarriers
developed.
Methods:
In the first section of this review, the physical and chemical properties of MSNs making
it an ideal delivery system for cancer therapy and diagnostics are discussed. In the next section,
various techniques involved in synthesizing and loading MSNs, including the influence of basic
components of MSNs and reaction conditions on its properties are reviewed. Then the wide application
of MSNs and various exogenous and endogenous stimuli harnessed for site-specific delivery
of cargo and recent patents on modifying environmental conditions for large scale synthesis of
MSNs and its active targeting for cancer treatment and bioimaging are discussed.
Results:
Physico-chemical properties and synthetic protocols of MSNs justifying them to be a
promising nanovector to overcome the ill effects of traditional chemotherapy. The superlative attributes
of MSNs including, tunable size, morphology, high load volume, stability, ease of modifying
external and internal surface leverage applications in various dimensions of therapeutics, diagnostics,
and combinatorial drug delivery. MSNs surface functionalization can be harnessed for passive and
active targeting by either coating the surface with polymers or attaching various ligands.
Conclusion:
An ideal nano-carrier must have high loading efficiency, easily detectable, and must
have stimuli's sensitive, site-specific drug release. The patent study explores new dimensions on
MSNs synthesis by claiming new cost-effective templates and silica source, a more safe environment
for synthesis, reducing synthesis steps, duration of reaction, effective loading of low solubility
drugs by magnetized nanocarriers, pathogen-specific release and development of novel photoluminescent
rechargeable MSNs under mild conditions. It’s a challenging task for researchers to
successfully translate their prototypes to industries and make it feasible for commercialization. We
can further work on excellent targeting concepts and architecture of MSNs for the increased opportunity
in cancer theranostics.
Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment