Biodegradable Flexible Electronic Device with Controlled Drug Release for Cancer Treatment

2021 ◽  
Author(s):  
Hangfei Li ◽  
Fei Gao ◽  
Peng Wang ◽  
Lan Yin ◽  
Nan Ji ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Electronic Device ◽  
Controlled Drug Release ◽  
Flexible Electronic ◽  
Flexible Electronic Device

Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

2019 ◽  
Vol 7 (7) ◽  
pp. 1050-1055 ◽  
Author(s):  
Liangcan He ◽  
Kanglei Pang ◽  
Wenwen Liu ◽  
Yue Tian ◽  
Lin Chang ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Core Shell ◽  
Treatment Efficiency ◽  
Zeolitic Imidazolate Framework ◽  
High Drug ◽  
High Drug Loading

Core–shell Au@zeolitic-imidazolate-framework nanocarriers with high drug-loading, controlled drug release properties, and high cancer treatment efficiency.

scholarly journals Inorganic islands on a highly stretchable polyimide substrate

2009 ◽  
Vol 24 (11) ◽  
pp. 3338-3342 ◽  
Author(s):  
Jeong-Yun Sun ◽  
Nanshu Lu ◽  
Juil Yoon ◽  
Kyu-Hwan Oh ◽  
Zhigang Suo ◽  
...  
Keyword(s):  
Thin Layer ◽  
Electronic Device ◽  
Large Strain ◽  
Inorganic Materials ◽  
Polymer Substrate ◽  
Polyimide Substrate ◽  
Small Strains ◽  
Flexible Electronic ◽  
Flexible Electronic Device ◽  
Highly Stretchable

For a flexible electronic device integrating inorganic materials on a polymer substrate, the polymer can deform substantially, but the inorganic materials usually fracture at small strains. This paper describes an approach to make such a device highly stretchable. A polyimide substrate is first coated with a thin layer of an elastomer, on top of which SiNx islands are fabricated. When the substrate is stretched to a large strain, the SiNx islands remain intact. Calculations confirm that the elastomer reduces the strain in the SiNx islands by orders of magnitude.

scholarly journals Injectable hydrogels of newly designed brush biopolymers as sustained drug-delivery vehicle for melanoma treatment

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Aparna Shukla ◽  
Akhand Pratap Singh ◽  
Pralay Maiti
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Treatment ◽  
Active Material ◽  
Methyl Cellulose ◽  
Controlled Drug Release ◽  
Biologically Active ◽  
In Vivo Studies ◽  
Injectable Hydrogel

AbstractNovel biocompatible and brush copolymers have been developed for cancer treatment using its controlled drug-release potential. Polyurethane graft on linear dextrin has been synthesized to control the hydrophilic–hydrophobic balance for regulated drug delivery. The properties of the graft copolymers have been tuned through graft density. The prepared grafts are thermally stable and mechanically strong. An injectable hydrogel has been developed by embedding the drug-loaded brush copolymers in methyl cellulose to better control the release for a prolonged period, importantly by keeping the drug release at a constant rate. Cellular studies indicate the biocompatible nature of the brush copolymers whose controlled and slow release of drug exhibit significant cytotoxic effects on cancer cells. Endocytosis of drug tagged contrast agent indicates greater transport of biologically active material inside cell as observed through cellular uptake studies. In vivo studies on melanoma mice exhibit the real efficacy of the controlled drug release from the injectable hydrogel with significant melanoma suppression without any side effects as opposed to severe toxic effects observed in conventional chemotherapy. Special application method of drug-loaded hydrogel just beneath the tumor makes this system incredibly effective through confinement. Thus, brush copolymer injectable hydrogel is a promising vehicle for control release of drug for cancer treatment in future.

P-92: Encapsulation Adhesive Possessing High Water Barrier and Low Corrosive Properties for Flexible Electronic Device

2014 ◽  
Vol 45 (1) ◽  
pp. 1332-1335 ◽  
Author(s):  
Satoshi Naganawa ◽  
Kenta Nishijima ◽  
Yoshiaki Hagihara ◽  
Yuta Suzuki ◽  
Koichi Nagamoto ◽  
...  
Keyword(s):  
Electronic Device ◽  
High Water ◽  
Water Barrier ◽  
Flexible Electronic ◽  
Flexible Electronic Device

scholarly journals Glutathione triggered degradation of polydopamine to facilitate controlled drug release for synergic combinational cancer treatment

2019 ◽  
Vol 7 (43) ◽  
pp. 6742-6750 ◽  
Author(s):  
Ya-Nan Hao ◽  
An-Qi Zheng ◽  
Ting-Ting Guo ◽  
Yang Shu ◽  
Jian-Hua Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Treatment ◽  
Controlled Drug Release ◽  
Core Shell

Here we report a novel mechanism for triggering drug release in the polydopamine (PDA)-coated magnetic CuCo2S4 core–shell nanostructure by glutathione (GSH) triggered degradation of PDA for release.

Sign in / Sign up

Export Citation Format

Share Document