Therapeutic Nanocarriers with Hydrogen Peroxide-Triggered Drug Release for Cancer Treatment

2013 ◽  
Vol 14 (5) ◽  
pp. 1627-1636 ◽  
Author(s):  
Jinyao Liu ◽  
Yan Pang ◽  
Zhaoyang Zhu ◽  
Dali Wang ◽  
Chunting Li ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Drug Release ◽  
Cancer Treatment ◽  
Triggered Drug Release

scholarly journals Triggered Drug Release From Liposomes: Exploiting the Outer and Inner Tumor Environment

2021 ◽  
Vol 11 ◽  
Author(s):  
Marina Santiago Franco ◽  
Eliza Rocha Gomes ◽  
Marjorie Coimbra Roque ◽  
Mônica Cristina Oliveira
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Treatment ◽  
Basic Principle ◽  
Tumor Tissue ◽  
Lymphatic Drainage ◽  
Active Targeting ◽  
Tumor Site ◽  
Tumor Environment ◽  
Triggered Drug Release

Since more than 40 years liposomes have being extensively studied for their potential as carriers of anticancer drugs. The basic principle behind their use for cancer treatment consists on the idea that they can take advantage of the leaky vasculature and poor lymphatic drainage present at the tumor tissue, passively accumulating in this region. Aiming to further improve their efficacy, different strategies have been employed such as PEGlation, which enables longer circulation times, or the attachment of ligands to liposomal surface for active targeting of cancer cells. A great challenge for drug delivery to cancer treatment now, is the possibility to trigger release from nanosystems at the tumor site, providing efficacious levels of drug in the tumor. Different strategies have been proposed to exploit the outer and inner tumor environment for triggering drug release from liposomes and are the focus of this review.

Facile synthesis of organosilica-capped mesoporous silica nanocarriers with selective redox-triggered drug release properties for safe tumor chemotherapy

2019 ◽  
Vol 7 (5) ◽  
pp. 1825-1832 ◽  
Author(s):  
Luying Shen ◽  
Shan Pan ◽  
Dechao Niu ◽  
Jianping He ◽  
Xiaobo Jia ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Facile Synthesis ◽  
Triggered Drug Release ◽  
Facile Route

We develop a facile route to synthesize organosilica-capped mesoporous silica nanocarriers for efficient and safe redox-triggered tumor chemotherapy.

scholarly journals pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid

RSC Advances ◽  
2021 ◽  
Vol 11 (16) ◽  
pp. 9222-9234
Author(s):  
Vy Anh Tran ◽  
Sang-Wha Lee
Keyword(s):  
Drug Release ◽  
Polyacrylic Acid ◽  
Acidic Ph ◽  
Zeolitic Imidazolate Framework ◽  
Triggered Drug Release

The ZIF8–Dox@PAA nanocarrier demonstrated pH-triggered drug release through the detachment of the PAA layer along with the destruction of ZIF8 framework in acidic pH environment.

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

Imaging Laser-Triggered Drug Release from Gold Nanocages with Transient Absorption Lifetime Microscopy

2017 ◽  
Vol 9 (23) ◽  
pp. 19653-19661 ◽  
Author(s):  
Yongkui Xu ◽  
Qi Liu ◽  
Ruoyu He ◽  
Xianchong Miao ◽  
Minbiao Ji
Keyword(s):  
Drug Release ◽  
Transient Absorption ◽  
Gold Nanocages ◽  
Triggered Drug Release
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