Impact of the biomolecular corona on the structure of PEGylated liposomes

2017 ◽  
Vol 5 (9) ◽  
pp. 1884-1888 ◽  
Author(s):  
Luca Digiacomo ◽  
Daniela Pozzi ◽  
Heinz Amenitsch ◽  
Giulio Caracciolo
Keyword(s):  
Protein Corona ◽  
Cationic Liposomes ◽  
Particle Aggregation ◽  
Bilayer Structure ◽  
Pegylated Liposomes ◽  
P Protein ◽  
Pegylated Cationic Liposomes

Protein corona affects the bilayer structure of PEGylated cationic liposomes thus promoting the formation of multilamellar complexes and particle aggregation.

scholarly journals Novel PEGylated Liposomes Enhance Immunostimulating Activity of isRNA

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3101 ◽  
Author(s):  
Tatyana Kabilova ◽  
Elena Shmendel ◽  
Daniil Gladkikh ◽  
Nina Morozova ◽  
Mikhail Maslov ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Cationic Liposomes ◽  
Circulation Time ◽  
Target Cells ◽  
Immunostimulating Activity ◽  
Pegylated Liposomes ◽  
Liposome Preparation ◽  
Molecular Masses

The performance of cationic liposomes for delivery of therapeutic nucleic acids in vivo can be improved and specifically tailored to certain types of cargo and target cells by incorporation of PEG-containing lipoconjugates in the cationic liposome’s composition. Here, we report on the synthesis of novel PEG-containing lipoconjugates with molecular masses of PEG 800, 1500 and 2000 Da. PEG-containing lipoconjugates were used as one of the components in liposome preparation with the polycationic amphiphile 1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetra-azahexacosan tetrahydrochloride (2X3) and the lipid-helper dioleoylphosphatidylethanolamine (DOPE). We demonstrate that increasing the length of the PEG chain reduces the transfection activity of liposomes in vitro, but improves the biodistribution, increases the circulation time in the bloodstream and enhances the interferon-inducing activity of immunostimulating RNA in vivo.

Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model

2009 ◽  
Vol 134 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Amr Abu-Lila ◽  
Takuya Suzuki ◽  
Yusuke Doi ◽  
Tatsuhiro Ishida ◽  
Hiroshi Kiwada
Keyword(s):  
Mouse Model ◽  
Cationic Liposomes ◽  
Pegylated Cationic Liposomes

Disease-specific protein corona sensor arrays may have disease detection capacity

2019 ◽  
Vol 4 (5) ◽  
pp. 1063-1076 ◽  
Author(s):  
Giulio Caracciolo ◽  
Reihaneh Safavi-Sohi ◽  
Reza Malekzadeh ◽  
Hossein Poustchi ◽  
Mahdi Vasighi ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Sensor Array ◽  
Sensor Arrays ◽  
Protein Corona ◽  
Specific Protein ◽  
Disease Detection ◽  
P Protein ◽  
Array Technology ◽  
Disease Specific

Protein corona sensor array technology identifies diseases through specific proteomics pattern recognition.

scholarly journals The protein corona of circulating PEGylated liposomes

2016 ◽  
Vol 1858 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Sara Palchetti ◽  
Valentina Colapicchioni ◽  
Luca Digiacomo ◽  
Giulio Caracciolo ◽  
Daniela Pozzi ◽  
...  
Keyword(s):  
Protein Corona ◽  
Pegylated Liposomes

Protein corona profile of graphene oxide allows detection of glioblastoma multiforme using a simple one-dimensional gel electrophoresis technique: a proof-of-concept study

2021 ◽  
Author(s):  
Riccardo Di Santo ◽  
Erica Quagliarini ◽  
Luca Digiacomo ◽  
Daniela Pozzi ◽  
Angelina Di Carlo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Glioblastoma Multiforme ◽  
Gel Electrophoresis ◽  
Blood Test ◽  
Protein Corona ◽  
Proof Of Concept ◽  
One Dimensional ◽  
Concept Study ◽  
P Protein ◽  
Electrophoresis Technique

Protein Corona-based blood test for the detection of glioblastoma multiforme.

Elucidating the Encapsulation of Short Interfering RNA in PEGylated Cationic Liposomes

Langmuir ◽  
2009 ◽  
Vol 25 (9) ◽  
pp. 4886-4891 ◽  
Author(s):  
Kevin Buyens ◽  
Joseph Demeester ◽  
Stefaan S. De Smedt ◽  
Niek N. Sanders
Keyword(s):  
Cationic Liposomes ◽  
Short Interfering Rna ◽  
Pegylated Cationic Liposomes ◽  
Interfering Rna

Charged surface groups of nanoparticles and the adsorbed proteins codetermine the fate of nanoparticles upon interacting with cells

RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 58315-58324 ◽  
Author(s):  
Ke Huang ◽  
Yang Hu ◽  
Changjun Yu ◽  
Rena Boerhan ◽  
Guoqiang Jiang
Keyword(s):  
Intracellular Transport ◽  
Protein Corona ◽  
Surface Groups ◽  
Charged Surface ◽  
P Protein ◽  
Adsorbed Proteins

Protein corona had impact on the endocytosis mechanism and then the intracellular transport of NPs, especially the exocytosis.

scholarly journals Protein source and choice of anticoagulant decisively affect nanoparticle protein corona and cellular uptake

Nanoscale ◽  
2016 ◽  
Vol 8 (10) ◽  
pp. 5526-5536 ◽  
Author(s):  
S. Schöttler ◽  
Katja Klein ◽  
K. Landfester ◽  
V. Mailänder
Keyword(s):  
Human Plasma ◽  
Cellular Uptake ◽  
Protein Corona ◽  
Protein Source ◽  
Protein Sources ◽  
P Protein

Protein corona investigations use different protein sources. Outcome of investigations is crucial. Human plasma seems to be a better choice than serum from animals or also human.

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