scholarly journals Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography

2017 ◽  
Vol 5 (7) ◽  
pp. 1265-1278 ◽  
Author(s):  
Yaqi Wo ◽  
Li-Chong Xu ◽  
Zi Li ◽  
Adam J. Matzger ◽  
Mark E. Meyerhoff ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Surface Topography ◽  
Polymer Films ◽  
Bacterial Adhesion ◽  
Synergistic Effects ◽  
Textured Surface ◽  
No Release ◽  
Nitric Oxide Releasing

SNAP-impregnated textured polymer films having up to 38 day NO-release were shown to have synergistic effects in inhibiting bacterial adhesion.

scholarly journals Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing

2020 ◽  
Vol 11 (1) ◽  
pp. 186-194 ◽  
Author(s):  
Yutian Duan ◽  
Yong Wang ◽  
Xiaohu Li ◽  
Guozhen Zhang ◽  
Guoying Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
No Release ◽  
Nitric Oxide Releasing

Nitric oxide-releasing amphiphiles are successfully synthesized through direct polymerization and are engineered as photoresponsive polymersomes for biomedical applications.

scholarly journals The preparation and characterization of nitric oxide releasing silicone rubber materials impregnated with S-nitroso-tert-dodecyl mercaptan

2016 ◽  
Vol 4 (3) ◽  
pp. 422-430 ◽  
Author(s):  
Alex R. Ketchum ◽  
Michael P. Kappler ◽  
Jianfeng Wu ◽  
Chuanwu Xi ◽  
Mark E. Meyerhoff
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Silicone Rubber ◽  
Storage Stability ◽  
No Release ◽  
Nitric Oxide Releasing ◽  
Dodecyl Mercaptan

Silicone rubber catheters impregnated with S-nitroso-tert-dodecylmercaptan demonstrate long term NO release, minimal leaching, considerable antimicrobial activity, and reasonable storage stability.

Sol−Gel Derived Nitric-Oxide Releasing Materials that Reduce Bacterial Adhesion

2001 ◽  
Vol 123 (39) ◽  
pp. 9712-9713 ◽  
Author(s):  
Brian J. Nablo ◽  
Ta-Yung Chen ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Bacterial Adhesion ◽  
Sol Gel ◽  
Nitric Oxide Releasing

Plasma-modified nitric oxide-releasing polymer films exhibit time-delayed 8-log reduction in growth of bacteria

2016 ◽  
Vol 11 (3) ◽  
pp. 031005 ◽  
Author(s):  
Michelle N. Mann ◽  
Bella H. Neufeld ◽  
Morgan J. Hawker ◽  
Adoracion Pegalajar-Jurado ◽  
Lindsey N. Paricio ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Polymer Films ◽  
Log Reduction ◽  
Nitric Oxide Releasing ◽  
Growth Of Bacteria

Hollow double-layered polymer microspheres with pH and thermo-responsive properties as nitric oxide-releasing reservoirs

2015 ◽  
Vol 6 (17) ◽  
pp. 3305-3314 ◽  
Author(s):  
Tuanwei Liu ◽  
Wei Zhang ◽  
Tao Song ◽  
Xinlin Yang ◽  
Chenxi Li
Keyword(s):  
Nitric Oxide ◽  
Polymer Microspheres ◽  
Release Behavior ◽  
Wide Range ◽  
No Release ◽  
Nitric Oxide Releasing

TheN-diazeniumdiolated hollow double-layered P(AmEMA-co-EGDMA)/P(NIPAAm-co-DMAEMA-co-EGDMA) microspheres (NO as 3.0 μmol mg−1) show a steady NO release behavior in a wide range of pHs (5–9) and temperatures (20–55 °C).

scholarly journals Reconsidering the Role of Cyclooxygenase Inhibition in the Chemotherapeutic Value of NO-Releasing Aspirins for Lung Cancer

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1924
Author(s):  
Antonia Martin-Martin ◽  
Andrés Rivera-Dictter ◽  
Matías Muñoz-Uribe ◽  
Freddy López-Contreras ◽  
Jorge Pérez-Laines ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Cancer ◽  
Mode Of Action ◽  
Synergistic Effects ◽  
Growth Factor Receptor ◽  
Parent Drug ◽  
Cancer Models ◽  
Epidermal Growth ◽  
And Migration ◽  
Nitric Oxide Releasing

Nitric oxide-releasing aspirins (NO-aspirins) are aspirin derivatives that are safer than the parent drug in the gastrointestinal context and have shown superior cytotoxic effects in several cancer models. Despite the rationale for their design, the influence of nitric oxide (NO•) on the effects of NO-aspirins has been queried. Moreover, different isomers exhibit varying antitumor activity, apparently related to their ability to release NO•. Here, we investigated the effects and mode of action of NO-aspirins in non-small-cell lung cancer (NSCLC) cells, comparing two isomers, NCX4016 and NCX4040 (-meta and -para isomers, respectively). NCX4040 was more potent in decreasing NSCLC cell viability and migration and exhibited significant synergistic effects in combination with erlotinib (an epidermal growth factor receptor inhibitor) in erlotinib-resistant cells. We also studied the relationship among the effects of NO-aspirins, NO• release, and PGE2 levels. NCX4040 released more NO• and significantly decreased PGE2 synthesis relative to NCX4016; however, NO• scavenger treatment reversed the antiproliferative effects of NCX4016, but not those of NCX4040. By contrast, misoprostol (a PGE2 receptor agonist) significantly reversed the antiproliferative effect of NCX4040, but not those of NCX4016. Furthermore, misoprostol reversed the antimigratory effects of NCX4040. Overall, these results indicate that PGE2 inhibition is important in the mode of action of NO-aspirins.

scholarly journals Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 926
Author(s):  
Jiafu Cao ◽  
Mingzhi Su ◽  
Nurhasni Hasan ◽  
Juho Lee ◽  
Dongmin Kwak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Pluronic F127 ◽  
Scanning Calorimetry ◽  
No Release ◽  
Infected Wounds ◽  
Nitric Oxide Releasing

Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing. Here, we developed an NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed of S-nitrosoglutathione (GSNO), pluronic F127 (PL), and alginate (AL) for the treatment of infected wounds. The GSNO was incorporated into the thermoresponsive PL/AL hydrogel, and differential scanning calorimetry techniques were used for the hydrogel characterization. The hydrogel was assessed by in vitro NO release, antibacterial activity, cytotoxicity, and wound-healing activity. The GSNO-PL/AL hydrogel demonstrated thermal responsiveness and biocompatibility, and it showed sustained NO release for 7 days. It also exhibited potent bactericidal activity against Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative multidrug-resistant Pseudomonas aeruginosa (MRPA). Moreover, the GSNO-PL/AL treatment of MRPA-infected wounds accelerated healing with a reduced bacterial burden in the wounds. The GSNO-PL/AL hydrogel would be a promising option for the treatment of infected wounds.

scholarly journals Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

2015 ◽  
Vol 3 (8) ◽  
pp. 1639-1645 ◽  
Author(s):  
Elizabeth J. Brisbois ◽  
Ryan P. Davis ◽  
Anna M. Jones ◽  
Terry C. Major ◽  
Robert H. Bartlett ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bacterial Adhesion ◽  
Sheep Model ◽  
Doped Polymers ◽  
Nitric Oxide Releasing

Nitric oxide-releasing catheters, prepared with S-nitroso-N-acetylpenicillamine doped polymers, reduce thrombus and bacterial adhesion in a 7 day sheep model.

Correlating S-nitrosothiol decomposition and NO release for modified poly(lactic-co-glycolic acid) polymer films

RSC Advances ◽  
2014 ◽  
Vol 4 (79) ◽  
pp. 42039-42043 ◽  
Author(s):  
J. M. Joslin ◽  
B. H. Neufeld ◽  
Melissa M. Reynolds
Keyword(s):  
Nitric Oxide ◽  
Polymer Films ◽  
Glycolic Acid ◽  
No Release

The decomposition of an S-nitrosated model polymer was correlated to the subsequent release of nitric oxide under multiple decomposition pathways.

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