Hollow double-layered polymer microspheres with pH and thermo-responsive properties as nitric oxide-releasing reservoirs

2015 ◽  
Vol 6 (17) ◽  
pp. 3305-3314 ◽  
Author(s):  
Tuanwei Liu ◽  
Wei Zhang ◽  
Tao Song ◽  
Xinlin Yang ◽  
Chenxi Li
Keyword(s):  
Nitric Oxide ◽  
Polymer Microspheres ◽  
Release Behavior ◽  
Wide Range ◽  
No Release ◽  
Nitric Oxide Releasing

TheN-diazeniumdiolated hollow double-layered P(AmEMA-co-EGDMA)/P(NIPAAm-co-DMAEMA-co-EGDMA) microspheres (NO as 3.0 μmol mg−1) show a steady NO release behavior in a wide range of pHs (5–9) and temperatures (20–55 °C).

scholarly journals Light-triggered nitric oxide (NO) release from photoresponsive polymersomes for corneal wound healing

2020 ◽  
Vol 11 (1) ◽  
pp. 186-194 ◽  
Author(s):  
Yutian Duan ◽  
Yong Wang ◽  
Xiaohu Li ◽  
Guozhen Zhang ◽  
Guoying Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Corneal Wound Healing ◽  
Corneal Wound ◽  
No Release ◽  
Nitric Oxide Releasing

Nitric oxide-releasing amphiphiles are successfully synthesized through direct polymerization and are engineered as photoresponsive polymersomes for biomedical applications.

scholarly journals The preparation and characterization of nitric oxide releasing silicone rubber materials impregnated with S-nitroso-tert-dodecyl mercaptan

2016 ◽  
Vol 4 (3) ◽  
pp. 422-430 ◽  
Author(s):  
Alex R. Ketchum ◽  
Michael P. Kappler ◽  
Jianfeng Wu ◽  
Chuanwu Xi ◽  
Mark E. Meyerhoff
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Silicone Rubber ◽  
Storage Stability ◽  
No Release ◽  
Nitric Oxide Releasing ◽  
Dodecyl Mercaptan

Silicone rubber catheters impregnated with S-nitroso-tert-dodecylmercaptan demonstrate long term NO release, minimal leaching, considerable antimicrobial activity, and reasonable storage stability.

scholarly journals Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography

2017 ◽  
Vol 5 (7) ◽  
pp. 1265-1278 ◽  
Author(s):  
Yaqi Wo ◽  
Li-Chong Xu ◽  
Zi Li ◽  
Adam J. Matzger ◽  
Mark E. Meyerhoff ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Surface Topography ◽  
Polymer Films ◽  
Bacterial Adhesion ◽  
Synergistic Effects ◽  
Textured Surface ◽  
No Release ◽  
Nitric Oxide Releasing

SNAP-impregnated textured polymer films having up to 38 day NO-release were shown to have synergistic effects in inhibiting bacterial adhesion.

scholarly journals Nitric Oxide-Releasing Thermoresponsive Pluronic F127/Alginate Hydrogel for Enhanced Antibacterial Activity and Accelerated Healing of Infected Wounds

Pharmaceutics ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 926
Author(s):  
Jiafu Cao ◽  
Mingzhi Su ◽  
Nurhasni Hasan ◽  
Juho Lee ◽  
Dongmin Kwak ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Antibacterial Activity ◽  
Multidrug Resistant ◽  
Pluronic F127 ◽  
Scanning Calorimetry ◽  
No Release ◽  
Infected Wounds ◽  
Nitric Oxide Releasing

Nitric oxide (NO), a highly reactive and lipophilic molecule, is one of the molecules present in the wound environment and implicated as an important regulator in all phases of wound healing. Here, we developed an NO-releasing thermoresponsive hydrogel (GSNO-PL/AL) composed of S-nitrosoglutathione (GSNO), pluronic F127 (PL), and alginate (AL) for the treatment of infected wounds. The GSNO was incorporated into the thermoresponsive PL/AL hydrogel, and differential scanning calorimetry techniques were used for the hydrogel characterization. The hydrogel was assessed by in vitro NO release, antibacterial activity, cytotoxicity, and wound-healing activity. The GSNO-PL/AL hydrogel demonstrated thermal responsiveness and biocompatibility, and it showed sustained NO release for 7 days. It also exhibited potent bactericidal activity against Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative multidrug-resistant Pseudomonas aeruginosa (MRPA). Moreover, the GSNO-PL/AL treatment of MRPA-infected wounds accelerated healing with a reduced bacterial burden in the wounds. The GSNO-PL/AL hydrogel would be a promising option for the treatment of infected wounds.

Inducible nitric oxide releasing poly-(ethylene glycol)-fibrinogen adhesive hydrogels for tissue regeneration

2013 ◽  
Vol 1569 ◽  
pp. 39-44 ◽  
Author(s):  
Margaret Brunette ◽  
Hal Holmes ◽  
Michael G. Lancina ◽  
Weilue He ◽  
Bruce P. Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Tissue Regeneration ◽  
No Donor ◽  
Linear Elastic ◽  
Donor Cells ◽  
No Release ◽  
Hydrophobic Nature ◽  
Poly Ethylene ◽  
Lower Ratio ◽  
Nitric Oxide Releasing

ABSTRACTNitric oxide (NO) release can promote healthy tissue regeneration. A PEG-fibrinogen adhesive hydrogel that would allow for inducible NO release was created with mechanical properties that could be tailored to specific applications and tissue types. PEG (4-arm)-fibrinogen hydrogels of varying ratios were derivatized with S-nitroso-N-acetyl-D, L-penicillamine (SNAP)-thiolactone to create an active NO donor material. Controlled release from gels was established using light as the activating source, although temperature, pH, and external mechanical loading are also means to induce active NO release. Gels with varying ratios of fibrinogen to PEG were made, derivatized, and tested. Gels below a ratio of 1.5:1 (fibrinogen:PEG) did not gel, while at ratio of 1.5:1 gelation occurs and NO release can be induced. Interestingly, the release from 1.5:1 gels was significantly lower compared to 2:1 and 3:1 gel formulations. Rheometric data show that lower ratio gels are more elastic than viscous. Derivatized gels exhibited linear elastic moduli, behaving more like other more synthetic hydrogels. Swelling data indicates that as the ratio of fibrinogen to PEG increases the swelling ratio decreases, likely due to the hydrophobic nature of the NO donor. Cells remain viable on both derivatized and non-derivatized gels.

Nitric Oxide-Releasing Biomaterials for Biomedical Applications

2016 ◽  
Vol 23 (24) ◽  
pp. 2579-2601 ◽  
Author(s):  
Xin Zhou ◽  
Jimin Zhang ◽  
Guowei Feng ◽  
Jie Shen ◽  
Deling Kong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biomedical Applications ◽  
Nitric Oxide Releasing

scholarly journals Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration

2021 ◽  
Vol 11 (13) ◽  
pp. 6041
Author(s):  
Kwan-Hee Yun ◽  
Mi-Ja Ko ◽  
Yong-Kown Chae ◽  
Koeun Lee ◽  
Ok-Hyung Nam ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Standard Deviation ◽  
Treatment Group ◽  
Root Surface ◽  
Lower Grade ◽  
Histomorphometric Analysis ◽  
Pulp Regeneration ◽  
Pulp Inflammation ◽  
Nitric Oxide Releasing ◽  
Rat Molar

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treatment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard deviation) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

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