The development of a biomimetic enzyme-linked immunosorbent assay based on the molecular imprinting technique for the detection of enrofloxacin in animal-based food

2017 ◽  
Vol 9 (47) ◽  
pp. 6682-6688 ◽  
Author(s):  
Jing Wang ◽  
Yaxin Sang ◽  
Weihua Liu ◽  
Na Liang ◽  
Xianghong Wang
Keyword(s):  
Immunosorbent Assay ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Enzyme Linked Immunosorbent Assay ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Imprinting Technique

In this study, a direct competitive biomimetic enzyme-linked immunosorbent assay (BELISA) method using molecularly imprinted polymers (MIPs) as artificial antibodies was developed to detect enrofloxacin (ENRO) in animal-based food.

scholarly journals A convenient separation method for di(2-ethylhexyl)phthalate by novel superparamagnetic molecularly imprinted polymers

RSC Advances ◽  
2018 ◽  
Vol 8 (63) ◽  
pp. 36191-36199 ◽  
Author(s):  
Xinhua Yuan ◽  
Tiantian Liu ◽  
Lei Gao ◽  
Lu Xing ◽  
Yingying Zhu ◽  
...  
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Separation Method ◽  
Surface Molecular Imprinting ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Imprinting Technique ◽  
Surface Molecular Imprinting Technique ◽  
Ethylhexyl Phthalate

Through surface molecular imprinting technique and coating superparamagnetic Fe3O4 nanoparticles with molecularly imprinted polymers, a novel MMIP was successfully fabricated for the convenient separation of DEHP.

Fluorescence signaling molecularly imprinted polymers for antibiotics prepared via site-directed post-imprinting introduction of plural fluorescent reporters within the recognition cavity

2016 ◽  
Vol 4 (44) ◽  
pp. 7138-7145 ◽  
Author(s):  
Hirobumi Sunayama ◽  
Takeo Ohta ◽  
Atsushi Kuwahara ◽  
Toshifumi Takeuchi
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Fluorescent Dyes ◽  
Specific Binding ◽  
Fluorescence Signal ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Fluorescent Reporters ◽  
Binding Event ◽  
Fluorescence Signaling

An antibiotic-imprinted cavity with two different fluorescent dyes was prepared by molecular imprinting and subsequent post-imprinting modifications (PIMs), for the readout of a specific binding event as a fluorescence signal.

Materials Strategies for Advanced Nano Technology

2007 ◽  
Vol 1004 ◽  
Author(s):  
Kyung Choi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Soft Lithography ◽  
Functional Polymers ◽  
High Fidelity ◽  
Nano Technology ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Synthetic Receptor ◽  
Receptor Sites ◽  
Molecular Imprinting Technique

AbstractWe demonstrate functional microfabrications generated using photocurable functional polymers. We synthesized photocurable silicon elastomers, which can be useful for high fidelity, nano-scale soft lithography. ‘Elastic photopatterns’ generated by using the designed photocuarble silicon elastomers was presented. Molecularly imprinted polymers (MIP) are produced by “molecular imprinting technique”, which is a general protocol for the preparation of “synthetic receptor sites”. We then used the MIP's system for functional pattern fabrications to improve the sensitivity of molecular recognitions. Those functional microfabrications are beneficial to develop actual devices with high performances.

Advances in Molecularly Imprinted Systems: Materials, Characterization Methods and Analytical Applications

2020 ◽  
Vol 16 (3) ◽  
pp. 196-207 ◽  
Author(s):  
Yeşeren Saylan ◽  
Adil Denizli
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
High Stability ◽  
Low Cost ◽  
Three Dimensional ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Wide Range ◽  
Physicochemical Features ◽  
Target Molecules

Introduction: A molecular imprinting is one of the fascinating modification methods that employ molecules as targets to create geometric cavities for recognition of targets in the polymeric matrix. This method provides a broad versatility to imprint target molecules with different size, three-dimensional structure and physicochemical features. In contrast to the complex and timeconsuming laboratory surface modification procedures, this method offers a rapid, sensitive, inexpensive, easy-to-use, and selective approach for the diagnosis, screening and monitoring disorders. Owing to their unique features such as high selectivity, physical and chemical robustness, high stability, low-cost and reusability of this method, molecularly imprinted polymers have become very attractive materials and been applied in various applications from separation to detection. Background: The aims of this review are structured according to the fundamentals of molecularly imprinted polymers involving essential elements, preparation procedures and also the analytical applications platforms. Finally, the future perspectives to increase the development of molecularly imprinted platforms. Methods: A molecular imprinting is one of the commonly used modification methods that apply target as a recognition element itself and provide a wide range of versatility to replica other targets with a different structure, size, and physicochemical features. A rapid, easy, cheap and specific recognition approach has become one of the investigation areas on, especially biochemistry, biomedicine and biotechnology. In recent years, several technologies of molecular imprinting method have gained prompt development according to continuous use and improvement of traditional polymerization techniques. Results: The molecularly imprinted polymers with excellent performances have been prepared and also more exciting and universal applications have been recognized. In contrast to the conventional methods, the imprinted systems have superior advantages including high stability, relative ease and low cost of preparation, resistance to elevated temperature, and pressure and potential application to various target molecules. In view of these considerations, molecularly imprinted systems have found application in various fields of analytical chemistry including separation, purification, detection and spectrophotometric systems. Conclusion: Recent analytical methods are reported to develop the binding kinetics of imprinted systems by using the development of other technologies. The combined platforms are among the most encouraging systems to detect and recognize several molecules. The diversity of molecular imprinting methods was overviewed for different analytical application platforms. There is still a requirement of more knowledge on the molecular features of these polymers. A next step would further be the optimization of different systems with more homogeneous and easily reachable recognition sites to reduce the laborious in the accessibility in the three-dimensional polymeric materials in sufficient recognition features and also better selectivity and sensitivity for a wide range of molecules.

Development of Improved Crosslinking Monomers for Molecularly Imprinted Materials

2002 ◽  
Vol 723 ◽  
Author(s):  
David A. Spivak ◽  
Martha Sibrian-Vazquez
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Polymer Complex ◽  
Functional Monomer ◽  
Design Synthesis ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Catalytic Sites ◽  
And Performance

AbstractMolecular imprinting involves the self-assembled complexation of a substrate to functional monomers to form a pre-polymer complex which is “locked-in” to place by copolymerization with an excess of crosslinking monomer. Removal of the template leaves binding or catalytic sites that are complementary in size, shape, and functionality to the template. Most of the research in molecularly imprinted materials has focused on choice of substrate or functional monomer of the pre-polymer complex. The cross-linking monomers have primarily been EGDMA or DVB, which are commercially available. Redirecting focus on the design of crosslinking monomers for molecular imprinting, we have developed new classes of crosslinked polymers to optimize the performance of molecularly imprinted polymers. The design of the new crosslinking monomers has followed two strategies: (1) development of new crosslinked materials for formation of the supporting matrix, and (2) development of crosslinking monomers that simultaneously serve as the functional monomer. The details of the design, synthesis, polymerization and performance of these new crosslinking monomers for molecularly imprinted polymers will be reported.

Signalling molecular recognition nanocavities with multiple functional groups prepared by molecular imprinting and sequential post-imprinting modifications for prostate cancer biomarker glycoprotein detection

2020 ◽  
Vol 8 (35) ◽  
pp. 7987-7993
Author(s):  
Tetsuro Saeki ◽  
Eri Takano ◽  
Hirobumi Sunayama ◽  
Yuri Kamon ◽  
Ryo Horikawa ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Molecular Recognition ◽  
Functional Groups ◽  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Cancer Biomarker ◽  
Glycoprotein P ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

Novel sequential post-imprinting modifications were demonstrated on the development of multi-functionalized molecularly imprinted polymers for a biomarker glycoprotein.

Water-compatible molecularly imprinted polymers prepared using metal–organic gel as porogen

RSC Advances ◽  
2015 ◽  
Vol 5 (103) ◽  
pp. 84601-84609 ◽  
Author(s):  
Li Ma ◽  
Lei Tang ◽  
Rong-Shan Li ◽  
Yan-Ping Huang ◽  
Zhao-Sheng Liu
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Metal Organic ◽  
Organic Gel

A novel water-compatible approach suitable for molecular imprinting was described by using metal–organic gel (MOG) as the porogenic solvent.

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