Label-free, resettable, and multi-readout logic gates based on chemically induced fluorescence switching of gold nanoclusters

2016 ◽  
Vol 4 (29) ◽  
pp. 7141-7147 ◽  
Author(s):  
Hao-Hua Deng ◽  
Fei-Fei Wang ◽  
Yin-Huan Liu ◽  
Hua-Ping Peng ◽  
Ke-Lin Li ◽  
...  
Keyword(s):  
Gold Nanoclusters ◽  
Logic Gates ◽  
Label Free ◽  
Chemically Induced ◽  
Fluorescence Switching ◽  
Logic System

A label-free, resettable, multi-readout, and fluorescent logic system was designed based on BSA/MPA–AuNCs.

scholarly journals Molecular logic gates: Encoded Multichromophore Response for Simultaneous Label-Free Detection Small 7/2010

Small ◽  
2010 ◽  
Vol 6 (7) ◽  
pp. NA-NA
Author(s):  
Constantin Pistol ◽  
Vincent Mao ◽  
Viresh Thusu ◽  
Alvin R. Lebeck ◽  
Chris Dwyer
Keyword(s):  
Logic Gates ◽  
Label Free ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Label Free Detection

scholarly journals Fluorogenic RNA Aptamers: A Nano-platform for Fabrication of Simple and Combinatorial Logic Gates

Nanomaterials ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 984 ◽  
Author(s):  
Victoria Goldsworthy ◽  
Geneva LaForce ◽  
Seth Abels ◽  
Emil Khisamutdinov
Keyword(s):  
Rna Binding ◽  
Fluorescent Dyes ◽  
Free Ligand ◽  
Logic Gates ◽  
Boolean Logic ◽  
Rna Aptamers ◽  
Nucleic Acid Detection ◽  
Rna Aptamer ◽  
Label Free ◽  
Half Adder

RNA aptamers that bind non-fluorescent dyes and activate their fluorescence are highly sensitive, nonperturbing, and convenient probes in the field of synthetic biology. These RNA molecules, referred to as light-up aptamers, operate as molecular nanoswitches that alter folding and fluorescence function in response to ligand binding, which is important in biosensing and molecular computing. Herein, we demonstrate a conceptually new generation of smart RNA nano-devices based on malachite green (MG)-binding RNA aptamer, which fluorescence output controlled by addition of short DNA oligonucleotides inputs. Four types of RNA switches possessing AND, OR, NAND, and NOR Boolean logic functions were created in modular form, allowing MG dye binding affinity to be changed by altering 3D conformation of the RNA aptamer. It is essential to develop higher-level logic circuits for the production of multi-task nanodevices for data processing, typically requiring combinatorial logic gates. Therefore, we further designed and synthetized higher-level half adder logic circuit by “in parallel” integration of two logic gates XOR and AND within a single RNA nanoparticle. The design utilizes fluorescence emissions from two different RNA aptamers: MG-binding RNA aptamer (AND gate) and Broccoli RNA aptamer that binds DFHBI dye (XOR gate). All computationally designed RNA devices were synthesized and experimentally tested in vitro. The ability to design smart nanodevices based on RNA binding aptamers offers a new route to engineer “label-free” ligand-sensing regulatory circuits, nucleic acid detection systems, and gene control elements.

DNAzyme catalytic beacons-based a label-free biosensor for copper using electrochemical impedance spectroscopy

RSC Advances ◽  
2016 ◽  
Vol 6 (8) ◽  
pp. 6679-6685 ◽  
Author(s):  
Wenyong Hu ◽  
Xiaobo Min ◽  
Xinyu Li ◽  
Shengxiang Yang ◽  
Langbo Yi ◽  
...  
Keyword(s):  
Electrochemical Impedance Spectroscopy ◽  
Impedance Spectroscopy ◽  
Electrochemical Impedance ◽  
Gold Nanoclusters ◽  
Label Free ◽  
Selective Method

In this study, we developed a novel selective method for copper quantification based on gold nanoclusters (GNCs) and DNAzyme.

Versatile and Programmable DNA Logic Gates on Universal and Label-Free Homogeneous Electrochemical Platform

2016 ◽  
Vol 88 (19) ◽  
pp. 9691-9698 ◽  
Author(s):  
Lei Ge ◽  
Wenxiao Wang ◽  
Ximei Sun ◽  
Ting Hou ◽  
Feng Li
Keyword(s):  
Logic Gates ◽  
Label Free

Berberine as a novel light-up i-motif fluorescence ligand and its application in designing molecular logic systems

2016 ◽  
Vol 52 (1) ◽  
pp. 179-182 ◽  
Author(s):  
Lijun Xu ◽  
Shanni Hong ◽  
Na Sun ◽  
Kewei Wang ◽  
Lu Zhou ◽  
...  
Keyword(s):  
Logic Gates ◽  
Label Free ◽  
Molecular Logic ◽  
Free Dna ◽  
Logic Systems

Berberine is reported as a light-up fluorescence ligand for i-motif structures, which enables the development of label-free DNA-based logic gates.

Fluorescence switching method for cascade detection of salicylaldehyde and zinc(II) ion using protein protected gold nanoclusters

2015 ◽  
Vol 74 ◽  
pp. 322-328 ◽  
Author(s):  
Xi Liu ◽  
Changhui Fu ◽  
Xiangling Ren ◽  
Huiyu Liu ◽  
Linlin Li ◽  
...  
Keyword(s):  
Gold Nanoclusters ◽  
Fluorescence Switching ◽  
Switching Method

scholarly journals Label-Free, Dual-Analyte Electrochemical Biosensors: A New Class of Molecular-Electronic Logic Gates

2010 ◽  
Vol 132 (25) ◽  
pp. 8557-8559 ◽  
Author(s):  
Fan Xia ◽  
Xiaolei Zuo ◽  
Renqiang Yang ◽  
Ryan J. White ◽  
Yi Xiao ◽  
...  
Keyword(s):  
Logic Gates ◽  
Electrochemical Biosensors ◽  
Label Free ◽  
Molecular Electronic ◽  
New Class ◽  
Electronic Logic

Lab-on-a-drop: biocompatible fluorescent nanoprobes of gold nanoclusters for label-free evaluation of phosphorylation-induced inhibition of acetylcholinesterase activity towards the ultrasensitive detection of pesticide residues

The Analyst ◽  
2014 ◽  
Vol 139 (18) ◽  
pp. 4620-4628 ◽  
Author(s):  
Ning Zhang ◽  
Yanmei Si ◽  
Zongzhao Sun ◽  
Shuai Li ◽  
Shuying Li ◽  
...  
Keyword(s):  
Pesticide Residues ◽  
Gold Nanoclusters ◽  
Acetylcholinesterase Activity ◽  
Ultrasensitive Detection ◽  
Label Free

The catalysis and phosphorylated inhibition of acetylcholinesterase were monitored using fluorescent AuNCs nanoprobes for detecting pesticide residues.

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