A review on synthesis methods of tricyclic 1,2,3,4-tetrahydrocarbazoles

In this review article, we discussed old to new synthetic methods used for the preparation of 1,2,3,4-Tetrahydrocarbazole (THCz) based on reported literature. Around the worldwide, various researchers energetically reported new synthetic methods for tetrahydrocarbazoles preparation using conventional method or microwave method or use of catalyst. This review will be helpful to synthetic and medicinal chemist to find selective method for the preparation of 1,2,3,4-Tetrahydrocarbazoles with good percentage yield and less time. This review will also useful to medicinal chemist to design new biologically active tetrahydrocarbazoles based on reported synthetic methods.

Cu-Catalyzed, Mn-Mediated Propargylation and Allenylation of Aldehydes with Propargyl Bromides

A simple, practical, and high chemo-selective method for the synthesis of propargyl alcohol and allenyl alcohols via Cu-catalyzed, Mn-mediated propargylation and allenylation of aldehydes with propargyl bromides has been established. When 3-bromo-1-propyne was conducted under the standard condition, the aldehydes were transformed to the corresponding propargylation products completely, while when 1-bromo-2-pentyne was used, allenic alcohol was the only product. Variety of homopropargyl alcohols and allenyl alcohols were obtained in high yields and the reaction is compatible with broad substrate scopes. In addition, the large-scale reaction could also be proceeded smoothly indicating the potential synthetic applications of this transformation.

Textual representation of emotions in Somerset Maugham’s “The Moon and Sixpence”

Somerset Maugham is one of the most “emotionally intense” authors in English literature. His greatest works always reveal the “inner life of the individual” (E. Etkind), a person’s susceptibility to various transformations under the influence of feelings and states (“Theater”, “Of Human Bondage”, “The Moon and Sixpence”). At the same time, the emotions being retransmitted when translating a literary text is one of the most difficult tasks in translation theory. As representatives of the architectonic to comprehend the world, emotions are always culturally specific and often do not have equivalents in another mentality and another language. Such are, for example, the English-language concepts (which, in turn, “explain” the emotion) “melancholia”, “blues” and others. The purpose of this work is to explain semantically the category of “emotionality” and understand its ideological and thematic significance in a literary text by comparing the material of two languages — the original English and Russian as the target language. The methods we have taken in the process of working on the text: descriptive, explanatory, emotion thematisation, denotative analysis, emotive analysis, hermeneutic, conceptual, and selective (method of sampling passionary couplings that is slots). Research hypothesis: The category of emotionality is involved in the reconstruction of characters’ images at the level of text perception (the theory of respondents). The means to retransmit emotions when translating a text depends on the mental attitudes of different ethnic groups, therefore, it is necessary to identify “intersection points” that are equally acceptable both for the original text and for its translation.

Hyperkalemic circulatory shock and cardiac arrest altered by therapeutic management: A case report

Hyperkalemia is one of the few potentially lethal electrolyte disturbances. Severe hyperkalemia (Serum potassium concentration > 6.5 mmol/L) occurs most commonly from renal failure or the release of potassium from cells and can cause circulatory shock, cardiac arrhythmias or cardiac arrest. Current BLS (Basic Life Support) and ACLS (Advanced Cardiovascular Life Support) protocol should be used to manage cardiac arrest associated with hyperkalemia. But early consideration should be given to using the selective method of therapeutic management in addition to standard ACLS protocols that can be provided rapidly, effectively in patients with cardiovascular instability. We describe here a case of chronic kidney disease and congestive heart failure who developed circulatory shock and eventually cardiac arrest due to hyperkalemia managed with Calcium Gluconate, Sodium Bicarbonate and Insulin along with standard advanced cardiovascular life support protocol. Keywords: Potassium, hyperkalemia, acidosis, calcium, insulin, cardiac arrest.

Detection of Chemotherapeutic Drug 6-Mercaptopurine Through Manipulating Localized Surface Plasmon Resonance Absorption of Silver Nanoplates

A new colorimetric method for the detection of chemotherapeutic drug 6-mercaptopurine (6-MP) is developed based on controlling localized surface plasmon resonance (LSPR) of triangular silver nanoplates (AgNPs). The triangular AgNPs can be etched by trace amount of Cl− and transformed to a disc-like shape, accompanied by a blueshift of the corresponding LSPR absorption band. With the protective effect of 6-MP, the AgNPs are hardly or partly to be etched by Cl−, resulting in a reversed shift of LSPR. Based on a linear relationship between LSPR wavelength change and the concentration of 6-MP, a fast, visual and selective method for 6-MP assay is established. This method has been successfully applied to the detection of 6-MP in tablets.

A Critical Study of G. H. A Juynboll's Methodology in the Study of Hadith

This article analyzes methodology of an Orientalist, G. H. A Juynboll in Hadīth. He is one of those western scholars who has focused on the second primary source of Islamic Law and has developed skeptical theories related to its authenticity and provenance. He relied on early scholars' theories in this discipline and supported their thesis with a bulk of arguments from the early Classical Islamic Sources. A follow-up of his methodology reveals some scientific methodological errors in his studies on Hadīth that led him to a false conclusion. This study discusses the loopholes in his methodology and supports every point with illustrative examples from his works, revealing that Juynboll followed a selective method in his studies and reached his desired/concocted conclusion.

Selective synthesis of α-organylthio esters and α-organylthio ketones from β-keto esters and sodium S-organyl sulfurothioates under basic conditions

We described herein a selective method to prepare α-organylthio esters and α-organylthio ketones by the reaction of β-keto esters with sodium S-benzyl sulfurothioate or sodium S-alkyl sulfurothioate (Bunte salts) under basic conditions in toluene as the solvent at 100 °C. When 4 equivalents of a base were used, a series of differently substituted α-thio esters were obtained with up to 90% yield. On the other hand, employing 2 equivalents of a base, α-thio ketones were achieved after 18 h under air. Furthermore, after a shorter reaction time, the isolation of keto–enol tautomers was possible, revealing them as significant intermediates for the mechanism elucidation.