Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells

2017 ◽  
Vol 5 (9) ◽  
pp. 1712-1723 ◽  
Author(s):  
Rui He ◽  
Mingxian Liu ◽  
Yan Shen ◽  
Zheru Long ◽  
Changren Zhou
Keyword(s):  
Tumor Cells ◽  
Glass Substrate ◽  
Halloysite Nanotubes ◽  
Nanotube Arrays ◽  
Polystyrene Sulfonate ◽  
Large Area ◽  
Self Assembled

Here, polystyrene sulfonate sodium (PSS) modified halloysite nanotubes were self-assembled into patterned coating on a glass substrate with ordered nanotube arrays for capture of tumor cells.

Fabrication of Anodic Aluminum Oxide Film on Large-Area Glass Substrate

2007 ◽  
Vol 10 (12) ◽  
pp. C69 ◽  
Author(s):  
Ching-Jung Yang ◽  
Shih-Wei Liang ◽  
Pu-Wei Wu ◽  
Chih Chen ◽  
Jia-Min Shieh
Keyword(s):  
Oxide Film ◽  
Aluminum Oxide ◽  
Glass Substrate ◽  
Anodic Aluminum Oxide ◽  
Large Area ◽  
Anodic Aluminum Oxide Film ◽  
Aluminum Oxide Film ◽  
Anodic Aluminum

Patterning Organic Fluorescent Molecules with SAM Patterns

2011 ◽  
Vol 1335 ◽  
Author(s):  
Qiong Wu ◽  
Juanyuan Hao ◽  
Shoulei Shi ◽  
Weifeng Wang ◽  
Nan Lu
Keyword(s):  
Organic Molecules ◽  
Low Cost ◽  
Substrate Surface ◽  
Large Area ◽  
Self Assembled Monolayer ◽  
Storage Duration ◽  
Light Emitting ◽  
High Throughput Method ◽  
Self Assembled ◽  
Fluorescent Molecules

ABSTRACTWe report a low-cost and high-throughput method to fabricate large-area light emitting pattern via thermal evaporation of organic molecules on the patterned self-assembled monolayer of homogenous 3-aminopropyltrimethoxysilane. This method is based on the selective deposition of the organic light emitting molecules on the template of self-assembled monolayer (SAM), which is patterned with nanoimprinting lithography. The selectivity can be controlled by adjusting the design of the pattern, the storage duration and the substrate temperature. The deposition selectivity of the molecules may be caused by the different binding energy of the molecules with the SAM and the substrate surface.

Self-Assembled Large-Area Annular Cavity Arrays with Tunable Cylindrical Surface Plasmons for Sensing

ACS Nano ◽  
2015 ◽  
Vol 9 (2) ◽  
pp. 1913-1925 ◽  
Author(s):  
Haibin Ni ◽  
Ming Wang ◽  
Tianyi Shen ◽  
Jing Zhou
Keyword(s):  
Surface Plasmons ◽  
Cylindrical Surface ◽  
Large Area ◽  
Self Assembled

Field Emission and Electrical Switching Properties of Large-Area CuTCNQ Nanotube Arrays

2010 ◽  
Vol 10 (1) ◽  
pp. 237-243 ◽  
Author(s):  
Huibiao Liu ◽  
Zheng Liu ◽  
Xuemin Qian ◽  
Yanbing Guo ◽  
Shuang Cui ◽  
...  
Keyword(s):  
Field Emission ◽  
Nanotube Arrays ◽  
Large Area ◽  
Electrical Switching

scholarly journals Linear and nonlinear optical characterization of self-assembled, large-area gold nanosphere metasurfaces with sub-nanometer gaps: errata

2018 ◽  
Vol 26 (8) ◽  
pp. 9614 ◽  
Author(s):  
Jake Fontana ◽  
Melissa Maldonado ◽  
Nicholas Charipar ◽  
Scott A. Trammell ◽  
Rafaela Nita ◽  
...  
Keyword(s):  
Nonlinear Optical ◽  
Optical Characterization ◽  
Large Area ◽  
Linear And Nonlinear ◽  
Gold Nanosphere ◽  
Self Assembled

scholarly journals Enumerating Circulating Tumor Cells with a Self-Assembled Cell Array (SACA) Chip: A Feasibility Study in Patients with Colorectal Cancer

Cancers ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 56 ◽  
Author(s):  
Hsueh-Yao Chu ◽  
Long-Sheng Lu ◽  
Wanying Cho ◽  
Shin-Yao Wu ◽  
Yu-Cheng Chang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Turnaround Time ◽  
Colorectal Cancers ◽  
Inferior Mesenteric Vein ◽  
Newly Diagnosed ◽  
Cell Array ◽  
Serum Carcinoembryonic Antigen ◽  
Self Assembled

Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide. Detecting and enumerating circulating tumor cells (CTCs) in patients with colorectal cancer emerged as an important prognostic tool which provides a direct estimate of metastatic potential. Improving the turnaround time and decreasing sample volume is critical for incorporating this liquid biopsy tool into routine practice. The objective of the current study was to validate the clinical feasibility of a self-assembled cell array (SACA) chip, a CTC counting platform with less than 4 h turnaround time, in patients with newly diagnosed colorectal cancers. In total, 179 patients with newly diagnosed colorectal cancers from a single institute were enrolled. Epithelial cell adhesion molecule positive (EpCAM(+)), cluster of differentiation 45 negative (CD45(−)) cells were isolated and enumerated from 2 mL of peripheral vein blood (PB) and inferior mesenteric vein blood (IMV) samples obtained during surgery. We found that the CTC count in PB but not IMV correlates with disease stages. Neoadjuvant chemotherapy did not lead to decreased CTC count in both types of blood samples. With cutoffs of four CTCs per 2 mL of blood, and serum carcinoembryonic antigen (CEA) level of 5 ng/mL, patients with non-metastatic disease were more likely to experience recurrence if they had high PB CTC count and high serum CEA concentration (odds ratio, 8.9). Our study demonstrates the feasibility of enumerating CTCs with a SACA chip in patients with colorectal cancer.

scholarly journals Tailoring Superconductivity in Large-Area Single-Layer NbSe2 via Self-Assembled Molecular Adlayers

Nano Letters ◽  
2020 ◽  
Author(s):  
Francesco Calavalle ◽  
Paul Dreher ◽  
Ananthu P. Surdendran ◽  
Wen Wan ◽  
Melanie Timpel ◽  
...  
Keyword(s):  
Single Layer ◽  
Large Area ◽  
Self Assembled

scholarly journals Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Michael J. Mitchell ◽  
Carlos A. Castellanos ◽  
Michael R. King
Keyword(s):  
Cell Adhesion ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Cancer Cell ◽  
Halloysite Nanotubes ◽  
Breast Adenocarcinoma ◽  
Hematogenous Metastasis ◽  
Mcf7 Cells ◽  
Nanostructured Surfaces ◽  
Cancer Cell Death

Hematogenous metastasis, the process of cancer cell migration from a primary to distal location via the bloodstream, typically leads to a poor patient prognosis. Selectin proteins hold promise in delivering drug-containing nanocarriers to circulating tumor cells (CTCs) in the bloodstream, due to their rapid, force-dependent binding kinetics. However, it is challenging to deliver such nanocarriers while avoiding toxic effects on healthy blood cells, as many possess ligands that adhesively interact with selectins. Herein, we describe a nanostructured surface to capture flowing cancer cells, while preventing human neutrophil adhesion. Microtube surfaces with immobilized halloysite nanotubes (HNTs) and E-selectin functionalized liposomal doxorubicin (ES-PEG L-DXR) significantly increased the number of breast adenocarcinoma MCF7 cells captured from flow, yet also significantly reduced the number of captured neutrophils. Neutrophils firmly adhered and projected pseudopods on surfaces coated only with liposomes, while neutrophils adherent to HNT-liposome surfaces maintained a round morphology. Perfusion of both MCF7 cells and neutrophils resulted in primarily cancer cell adhesion to the HNT-liposome surface, and induced significant cancer cell death. This work demonstrates that nanostructured surfaces consisting of HNTs and ES-PEG L-DXR can increase CTC recruitment for chemotherapeutic delivery, while also preventing healthy cell adhesion and uptake of therapeutic intended for CTCs.

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