scholarly journals Intravaginal poly-(D, L-lactic-co-glycolic acid)-(polyethylene glycol) drug-delivery nanoparticles induce pro-inflammatory responses with Candida albicans infection in a mouse model

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240789
Author(s):  
Taslima T. Lina ◽  
Shemedia J. Johnson ◽  
R. Doug Wagner
Keyword(s):  
Drug Delivery ◽  
Candida Albicans ◽  
Polyethylene Glycol ◽  
Mouse Model ◽  
Glycolic Acid ◽  
Inflammatory Responses ◽  
Candida Albicans Infection

scholarly journals Post-nano strategies for drug delivery: multistage porous silicon microvectors

2017 ◽  
Vol 5 (2) ◽  
pp. 207-219 ◽  
Author(s):  
Alessandro Venuta ◽  
Joy Wolfram ◽  
Haifa Shen ◽  
Mauro Ferrari
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Porous Silicon ◽  
Small Interfering Rna ◽  
Glycolic Acid ◽  
Interfering Rna

This review discusses several post-nano solutions for drug delivery based on porous silicon microparticles. DOPC, dioleoylphosphatidylcholine; PEG, polyethylene glycol; PLGA, poly(lactic-co-glycolic acid); siRNA, small interfering RNA.

scholarly journals Multi-Step Pathogenesis and Induction of Local Immune Response by Systemic Candida Albicans Infection in an Intravenous Challenge Mouse Model

2014 ◽  
Vol 15 (8) ◽  
pp. 14848-14867 ◽  
Author(s):  
Voon-Kin Chin ◽  
Kuan-Jeang Foong ◽  
Abdullah Maha ◽  
Basir Rusliza ◽  
Mohtarrudin Norhafizah ◽  
...  
Keyword(s):  
Immune Response ◽  
Candida Albicans ◽  
Mouse Model ◽  
Local Immune Response ◽  
Candida Albicans Infection

scholarly journals Novel Fluorinated Poly (Lactic-Co-Glycolic acid) (PLGA) and Polyethylene Glycol (PEG) Nanoparticles for Monitoring and Imaging in Osteoarthritis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 235
Author(s):  
Luana Zerrillo ◽  
Karthick Babu Sai Sankar Gupta ◽  
Fons A.W.M. Lefeber ◽  
Candido G. Da Silva ◽  
Federica Galli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Magnetic Resonance ◽  
Glycolic Acid ◽  
Near Infrared ◽  
Polymeric Nanoparticles ◽  
Imaging Techniques ◽  
Magnetic Resonance Imaging Mri

Polymeric nanoparticles (NPs) find many uses in nanomedicine, from drug delivery to imaging. In this regard, poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) particles are the most widely applied types of nano-systems due to their biocompatibility and biodegradability. Here we developed novel fluorinated polymeric NPs as vectors for multi-modal nanoprobes. This approach involved modifying polymeric NPs with trifluoroacetamide (TFA) and loading them with a near-infrared (NIR) dye for different imaging modalities, such as magnetic resonance imaging (MRI) and optical imaging. The PLGA-PEG-TFA NPs generated were characterized in vitro using the C28/I2 human chondrocyte cell line and in vivo in a mouse model of osteoarthritis (OA). The NPs were well absorbed, as confirmed by confocal microscopy, and were non-toxic to cells. To test the NPs as a drug delivery system for contrast agents of OA, the nanomaterial was administered via the intra-articular (IA) administration method. The dye-loaded NPs were injected in the knee joint and then visualized and tracked in vivo by fluorine-19 nuclear magnetic resonance and fluorescence imaging. Here, we describe the development of novel intrinsically fluorinated polymeric NPs modality that can be used in various molecular imaging techniques to visualize and track OA treatments and their potential use in clinical trials.

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