Surfactant-free synthesis of a water-soluble PEGylated nanographeneoxide/metal-oxide nanocomposite as engineered antimicrobial weaponry

2016 ◽  
Vol 4 (41) ◽  
pp. 6706-6715 ◽  
Author(s):  
Rahul Kumar Mishra ◽  
Yakov Shalom ◽  
Vijay Bhooshan Kumar ◽  
John H. T. Luong ◽  
Aharon Gedanken ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Metal Oxide ◽  
Water Soluble ◽  
High Antimicrobial Activity ◽  
Water Salt ◽  
Protein Rich

ZnCuO NPs deposited on NGO-PEG are non-toxic, exhibit high antimicrobial activity and show excellent dispersal in water, salt-rich and protein-rich solutions.

scholarly journals New Water-Soluble Condensed Heterocyclic Compounds with Antimicrobial Activity Based on Annulation Reactions of 8-Quinolinesulfenyl Halides with Natural Products and Alkenes

2021 ◽  
Vol 11 (18) ◽  
pp. 8532
Author(s):  
Vladimir A. Potapov ◽  
Roman S. Ishigeev ◽  
Lyudmila A. Belovezhets ◽  
Irina V. Shkurchenko ◽  
Svetlana V. Amosova
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Natural Products ◽  
Heterocyclic Compounds ◽  
Methyl Eugenol ◽  
Water Soluble ◽  
High Antimicrobial Activity ◽  
Enterococcus Durans ◽  
Terminal Alkenes ◽  
Styrene Derivatives

The annulation reactions of 8-quinolinesulfenyl halides with natural products and alkenes affording new water-soluble [1,4]thiazino[2,3,4-ij]quinolin-4-ium derivatives in high or quantitative yields are developed in this study. The reactions with styrene derivatives and terminal alkenes including allyl arenes proceed in a regioselective manner but with the opposite regiochemistry. The reactions with terminal alkenes including allyl arenes occur in an anti-Markovnikov fashion (regarding addition of the 8-quinolinesulfenyl electrophile to the double bond) to give 2-organyl-2Н,3Н-[1,4]thiazino[2,3,4-ij]quinolin-4-ium halides, while the reactions with styrene derivatives proceed in a Markovnikov fashion, leading to 3-substituted condensed heterocyclic compounds. In general, styrene derivatives demonstrate higher reactivity in the annulation reactions compared to the terminal alkenes. Antimicrobial activity of novel water-soluble compounds against Enterococcus durans, Bacillus subtilis and Escherichia coli are evaluated. The compounds with high antimicrobial activity are found. The annulation products of the reactions of 8-quinolinesulfenyl halides with 1H-indene, eugenol, methyl eugenol and 1-heptene, are superior in their activity compared to the antibiotic gentamicin.

Disinfection of Fruits with Activated Water

2019 ◽  
Vol 10 ◽  
pp. 1864-1872
Author(s):  
Prof. Teodora P. Popova
Keyword(s):  
Antimicrobial Activity ◽  
Aqueous Solutions ◽  
Antimicrobial Properties ◽  
The Other ◽  
Gram Negative Bacteria ◽  
High Antimicrobial Activity ◽  
Gram Negative ◽  
E Coli ◽  
Number Of Microorganisms ◽  
Lower Effect

The effect of ionized aqueous solutions (anolytes and catholyte) in the processing of fruits (cherries, morellos, and strawberries) for decontamination has been tested. Freshly prepared analytes and catholyte without the addition of salts were used, as well as stored for 7 months anolytes, prepared with 0.5% NaCl and a combination of 0.5% NaCl and 0.5% Na2CO3. The anolyte prepared with a combination of 0.5% NaCl and 0.5% Na2CO3, as well as the anolyte obtained with 0.5% NaCl, exhibit high antimicrobial activity against the surface microflora of strawberries, cherries, and sour cherries. They inactivate E. coli for 15 minutes. The other species of the fam. Enterobacteriaceae were also affected to the maximum extent, as is the total number of microorganisms, especially in cherries and sour cherries. Even stored for 7 months, they largely retain their antimicrobial properties. Anolyte and catholyte, obtained without the addition of salts, showed a lower effect on the total number of microorganisms, but had a significant effect on Gram-negative bacteria, and especially with regard to the sanitary indicative E. coli.

scholarly journals Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 896-900 ◽  
Author(s):  
Takashi Misawa ◽  
Chihiro Goto ◽  
Norihito Shibata ◽  
Motoharu Hirano ◽  
Yutaka Kikuchi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Human Cell ◽  
Hemolytic Activity ◽  
Rational Design ◽  
Cell Cytotoxicity ◽  
Amino Acid Residues ◽  
High Antimicrobial Activity ◽  
Cationic Amino Acid ◽  
Helical Peptide

Amphipathic helical peptideStripeshowed high antimicrobial activity, low hemolytic activity, and low human cell cytotoxicity.

Antimicrobial activity of metal oxide nanoparticles supported onto natural clinoptilolite

Chemosphere ◽  
2012 ◽  
Vol 88 (9) ◽  
pp. 1103-1107 ◽  
Author(s):  
Jasna Hrenovic ◽  
Jelena Milenkovic ◽  
Nina Daneu ◽  
Renata Matonickin Kepcija ◽  
Nevenka Rajic
Keyword(s):  
Antimicrobial Activity ◽  
Metal Oxide ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Natural Clinoptilolite

Chitosan-based synthesis of magnetically-driven nanocomposites with biogenic magnetite core, controlled silver size, and high antimicrobial activity

2012 ◽  
Vol 14 (9) ◽  
pp. 2550 ◽  
Author(s):  
Zdenka Marková ◽  
Karolína Šišková ◽  
Jan Filip ◽  
Klára Šafářová ◽  
Robert Prucek ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
High Antimicrobial Activity ◽  
Biogenic Magnetite

Isatin Derivatives Containing Sterically Hindered Phenolic Fragment and Water-Soluble Acyl Hydrazones on Their Basis: Synthesis and Antimicrobial Activity

2018 ◽  
Vol 88 (1) ◽  
pp. 57-67 ◽  
Author(s):  
A. V. Bogdanov ◽  
I. F. Zaripova ◽  
A. D. Voloshina ◽  
A. S. Strobykina ◽  
N. V. Kulik ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Water Soluble ◽  
Sterically Hindered ◽  
Isatin Derivatives

scholarly journals Proliferation of Antibiotic-Producing Bacteria and Concomitant Antibiotic Production as the Basis for the Antibiotic Activity of Jordan's Red Soils

2009 ◽  
Vol 75 (9) ◽  
pp. 2735-2741 ◽  
Author(s):  
Joseph O. Falkinham ◽  
Thomas E. Wall ◽  
Justin R. Tanner ◽  
Khaled Tawaha ◽  
Feras Q. Alali ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Incubation Period ◽  
Micrococcus Luteus ◽  
Antibiotic Production ◽  
Antibiotic Activity ◽  
Skin Infections ◽  
High Antimicrobial Activity ◽  
Methanol Extracts ◽  
Red Soils

ABSTRACT Anecdotes, both historical and recent, recount the curing of skin infections, including diaper rash, by using red soils from the Hashemite Kingdom of Jordan. Following inoculation of red soils isolated from geographically separate areas of Jordan, Micrococcus luteus and Staphylococcus aureus were rapidly killed. Over the 3-week incubation period, the number of specific types of antibiotic-producing bacteria increased, and high antimicrobial activity (MIC, ∼10 μg/ml) was observed in methanol extracts of the inoculated red soils. Antibiotic-producing microorganisms whose numbers increased during incubation included actinomycetes, Lysobacter spp., and Bacillus spp. The actinomycetes produced actinomycin C2 and actinomycin C3. No myxobacteria or lytic bacteriophages with activity against either M. luteus or S. aureus were detected in either soil before or after inoculation and incubation. Although protozoa and amoebae were detected in the soils, the numbers were low and did not increase over the incubation period. These results suggest that the antibiotic activity of Jordan's red soils is due to the proliferation of antibiotic-producing bacteria.

scholarly journals High antimicrobial activity of VLC isolated fractions from Bifurcaria bifurcata

2014 ◽  
Vol 1 ◽  
Author(s):  
Horta Andre ◽  
Pandeirada Raquel ◽  
Fernandes Lurdes ◽  
Alves Celso ◽  
Pinteus Susete ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
High Antimicrobial Activity ◽  
Bifurcaria Bifurcata

scholarly journals Quaternary Salts of Chitosan: History, Antimicrobial Features, and Prospects

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Douglas de Britto ◽  
Rejane Celi Goy ◽  
Sergio Paulo Campana Filho ◽  
Odilio B. G. Assis
Keyword(s):  
Physical Chemistry ◽  
Antimicrobial Activity ◽  
Drug Delivery Systems ◽  
Antimicrobial Properties ◽  
Water Soluble ◽  
Chemical Characteristics ◽  
Packaging Materials ◽  
Inhibitory Effects ◽  
Quaternary Salts ◽  
Derivatives Of

Recently, increasing attention has been paid to water-soluble derivatives of chitosan at its applications. The chemical characteristics and the antimicrobial properties of these salts can play significant role in pharmacological and food areas mainly as carriers for drug delivery systems and as antimicrobial packaging materials. In the current paper, a historical sequence of the main preparative methods, physical chemistry aspects, and antimicrobial activity of chitosan quaternized derivatives are presented and briefly discussed. In general, the results indicated that the quaternary derivatives had better inhibitory effects than the unmodified chitosan.

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