scholarly journals Quaternary Salts of Chitosan: History, Antimicrobial Features, and Prospects

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Douglas de Britto ◽  
Rejane Celi Goy ◽  
Sergio Paulo Campana Filho ◽  
Odilio B. G. Assis
Keyword(s):  
Physical Chemistry ◽  
Antimicrobial Activity ◽  
Drug Delivery Systems ◽  
Antimicrobial Properties ◽  
Water Soluble ◽  
Chemical Characteristics ◽  
Packaging Materials ◽  
Inhibitory Effects ◽  
Quaternary Salts ◽  
Derivatives Of

Recently, increasing attention has been paid to water-soluble derivatives of chitosan at its applications. The chemical characteristics and the antimicrobial properties of these salts can play significant role in pharmacological and food areas mainly as carriers for drug delivery systems and as antimicrobial packaging materials. In the current paper, a historical sequence of the main preparative methods, physical chemistry aspects, and antimicrobial activity of chitosan quaternized derivatives are presented and briefly discussed. In general, the results indicated that the quaternary derivatives had better inhibitory effects than the unmodified chitosan.

scholarly journals Thermoresponsive Poly(N-Isopropylacrylamide-co-Dimethylaminoethyl Methacrylate) Microgel Aqueous Dispersions with Potential Antimicrobial Properties

Polymers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 606 ◽  
Author(s):  
Coro Echeverría ◽  
Alejandro Aragón-Gutiérrez ◽  
Marta Fernández-García ◽  
Alexandra Muñoz-Bonilla ◽  
Daniel López
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Viscoelastic Behavior ◽  
Water Soluble ◽  
Alkylation Reaction ◽  
Aqueous Dispersions ◽  
Dimethylaminoethyl Methacrylate ◽  
Preliminary Study ◽  
Potential Antimicrobial Activity

The work herein describes the preparation of thermoresponsive microgels with potential antimicrobial properties. Most of the work performed so far regarding microgels with antimicrobial activity, deals with the ability of microgels to carry and release antibiotics or antimicrobial agents (antimicrobial peptides). The originality of this work lies in the possibility of developing intrinsic antimicrobial microgels by copolymerization of the well-known thermoresponsive monomer, N-isopropylacrylamide (NIPAM) with dimethylaminoethyl methacrylate (DMAEMA), a water-soluble monomer, to form microgels via precipitation polymerization (radical polymerization). Due to the presence of a tertiary amine in the DMAEMA comonomer, microgels can be modified by N-alkylation reaction with methyl and butyl iodide. This quaternization confers positive charges to the microgel surfaces and thus the potential antimicrobial activity. The effect of DMAEMA content and its quaternization with both, methyl and butyl iodide is evaluated in terms of thermal and surface charge properties, as well as in the microgel size and viscoelastic behavior. Finally, a preliminary study of the antimicrobial activity against different microorganisms is also performed in terms of minimum inhibitory concentration (MIC). From this study we determined that in contrast with butylated microgels, methylated ones show potential antimicrobial activity and good physical properties besides of maintaining microgel thermo-responsiveness.

scholarly journals Antimicrobial Properties of Water-Soluble Polysaccharides and Alcoholic Extracts of Laetiporus Sulphureus (Bull.) Murrill Mycelium and Development of Biotechnology for Its Production in Immobilized Culture on Bacterial Cellulose

2020 ◽  
Vol 65 (1-2) ◽  
pp. 10-14
Author(s):  
I. A. Gavryushina ◽  
T. I. Gromovykh ◽  
N. B. Feldman ◽  
S. V. Lutsenko ◽  
V. I. Ponomarenko ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Bacterial Cellulose ◽  
Synthetic Medium ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Water Soluble ◽  
Biologically Active ◽  
Aqueous Extracts ◽  
Gram Positive Bacteria ◽  
Immobilized Culture

The article discusses the development of a new method of producing Laetiporus sulphureus (Bull.) Murrill basidiomycete mycelium immobilized on a bacterial cellulose matrix. Mycelium contains biologically active compounds with antimicrobial activity against Gram-positive bacteria, including resistant staphylococcus. The aim of the work was to obtain immobilized mycelium by co-cultivation of L.sulphureus with the producer of bacterial cellulose Gluconacetobacter hansenii. The authors found that when co-culturing the basidial L.sulphureus strain with the bacterial cellulose producing G.hansenii strain, productivity increases by 3.2 times on H5/1 synthetic medium and by 1.9 times on natural Maltax-10 medium (concentration 5%). The resulting immobilized L.sulphureus mycelium has antibacterial properties; its aqueous extracts contain glucans.

scholarly journals Effect of Silver Nanopowder on Mechanical, Thermal and Antimicrobial Properties of Kenaf/HDPE Composites

Polymers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 3928
Author(s):  
Vikneswari Sanmuham ◽  
Mohamed Thariq Hameed Sultan ◽  
A. M. Radzi ◽  
Ahmad Adlie Shamsuri ◽  
Ain Umaira Md Shah ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Antimicrobial Activity ◽  
Antimicrobial Properties ◽  
Tensile Modulus ◽  
Inhibitory Effects ◽  
Elongation At Break ◽  
Improved Stability ◽  
Mechanical Tensile ◽  
Internal Mixer ◽  
Tga And Dsc

This study aims to investigate the effect of AgNPs on the mechanical, thermal and antimicrobial activity of kenaf/HDPE composites. AgNP material was prepared at different contents, from 0, 2, 4, 6, 8 to 10 wt%, by an internal mixer and hot compression at a temperature of 150 °C. Mechanical (tensile, modulus and elongation at break), thermal (TGA and DSC) and antimicrobial tests were performed to analyze behavior and inhibitory effects. The obtained results indicate that the effect of AgNP content displays improved tensile and modulus properties, as well as thermal and antimicrobial properties. The highest tensile stress is 5.07 MPa and was obtained at 10wt, TGA showed 10 wt% and had improved thermal stability and DSC showed improved stability with increased AgNP content. The findings of this study show the potential of incorporating AgNP concentrations as a secondary substitute to improve the performance in terms of mechanical, thermal and antimicrobial properties without treatment. The addition of AgNP content in polymer composite can be used as a secondary filler to improve the properties.

Water-soluble porphyrinoids as G-quadruplex binders and telomerase inhibitors

2016 ◽  
Vol 20 (08n11) ◽  
pp. 1041-1048 ◽  
Author(s):  
Yoshiya Ikawa ◽  
Sho Katsumata ◽  
Ryuichi Sakashita ◽  
Shinobu Sato ◽  
Shigeori Takenaka ◽  
...  
Keyword(s):  
Telomerase Activity ◽  
Inhibitory Effect ◽  
Water Soluble ◽  
Inhibitory Effects ◽  
Binding Ability ◽  
Telomerase Inhibitors ◽  
Expanded Porphyrins ◽  
G4 Dna ◽  
G Quadruplex ◽  
Derivatives Of

Water-soluble derivatives of three kinds of expanded porphyrins (N-fused pentaphyrin, hexaphyrin, and heptaphyrin) were synthesized and their binding ability to G-quadruplex (G4-) DNA was evaluated. The inhibitory effects on enzymatic telomere extension were also investigated together with other tetrapyrrolic porphyrinoids. While expanded porphyrins increased the melting temperature of G4-DNA more effectively than the regular porphyrins, a porphyrin isomer (N-confused porphyrin) showed the highest inhibitory effect on telomerase activity.

scholarly journals Screening of antibacterial and antifungal activities of selected Macedonian wild mushrooms

2013 ◽  
pp. 333-340 ◽  
Author(s):  
Daniela Nikolovska-Nedelkoska ◽  
Natalija Atanasova-Pancevska ◽  
Haris Amedi ◽  
Dafina Veleska ◽  
Emilija Ivanova ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Inhibitory Concentration ◽  
Methanolic Extract ◽  
Antimicrobial Properties ◽  
Inhibitory Effects ◽  
Antibacterial And Antifungal Activities ◽  
Microdilution Method ◽  
Methanolic Extracts ◽  
Antibacterial And Antifungal

Regarding the development of novel safe antimicrobials of natural origin, macrofungi became attractive for the researchers in the last decade. In this study, antimicrobial potential of methanolic extracts of six wild macromycetes (Boletus lupinus, Flammulina velutypes, Phellinus igniarius, Sarcodon imbricatus, Tricholoma aurantium, Xerocomus ichnusanus) was evaluated. In vitro antimicrobial activity was investigated by the microdilution method and minimum inhibitory concentration (MIC) was determined. Testing was conducted against eleven microorganisms, including six strains of bacteria and five species of fungi. Extracts showed selective antimicrobial properties while the activities depended both on the species of microorganism and on the type and concentration of extract. The evaluated extracts demonstrated antimicrobial activity, exhibiting more potent inhibitory effects on the growth of bacteria than on fungi. The highest antibacterial and antifungal activity was observed in methanolic extract of polypore fungus P. igniarius.

scholarly journals PECULIARITIES OF SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF GUANIDINE-CONTAINING CAR-BOXYMETHYLCELLULOSE DERIVATIVES

2021 ◽  
pp. 73-82
Author(s):  
Oliy Ravshanovich Akhmedov ◽  
Shavkat Abduganievich Shomurotov ◽  
Abbaskhan Sabirkhanovich Turaev
Keyword(s):  
Ph Value ◽  
Antimicrobial Properties ◽  
Water Soluble ◽  
Biologically Active ◽  
Molar Ratio ◽  
Cellulose Ester ◽  
Chemical Characteristics ◽  
Physical And Chemical Characteristics ◽  
Aldehyde Groups ◽  
Physical And Chemical

The article presents data on the synthesis and antimicrobial properties of guanidine-containing carboxymethylcellulose derivatives with different physical and chemical characteristics. The regularities of the reaction of nucleophilic substitution of aldehyde groups of modified Na-carboxymethylcellulose (Na-CMC) by guanidine under different conditions are studied. Based on the results obtained, it was found that the limit replacement of reactive electrophilic groups with nucleophilic reagent depends on the pH value of the medium, molar ratio of guanidine and the degree of oxidation of cellulose ester. By varying the reaction conditions and the number of aldehyde groups in the oxidized Na-CMC composition, the azometin derivatives differing in the content of nitrogen-containing fragments in the polymer chain were obtained. Chemical restoration of labile azomethine bonds was performed and water-soluble derivatives containing strong amino-bound guanidine groups were synthesized. The study shows and substantiates the influence of structural indices (degree of substitution, quantitative guanidine content, pKα values and nature of counterion) of macromolecular systems on antibacterial and antifungal properties. The developed approach of synthesis opens prospects for creation of antimicrobial derivatives with regulated physical and chemical characteristics and set biologically active properties.

Syntheses, Structures, and Antimicrobial Activity of New Remarkably Light-Stable and Water-Soluble Tris(pyrazolyl)methanesulfonate Silver(I) Derivatives of N-Methyl-1,3,5-triaza-7-phosphaadamantane Salt - [mPTA]BF4

2014 ◽  
Vol 54 (2) ◽  
pp. 434-440 ◽  
Author(s):  
Piotr Smoleński ◽  
Claudio Pettinari ◽  
Fabio Marchetti ◽  
M. Fátima C. Guedes da Silva ◽  
Giulio Lupidi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Water Soluble ◽  
Derivatives Of

Neurotoxicity and Neuroprotective Effects of Polyimides (PI) and Polyphenylenevinylene (PPV) against Hydrogen Peroxide (H2O2)

2011 ◽  
Vol 8 (2) ◽  
pp. 33
Author(s):  
Norfaezah Mazalan ◽  
Mazatulikhma Mat Zain ◽  
Nor Saliyana Jumali ◽  
Norhanim Mohalid ◽  
Zurina Shaameri ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Drug Delivery Systems ◽  
Neuronal Cells ◽  
Water Soluble ◽  
Brain Delivery ◽  
Specific Therapy ◽  
Neuroprotective Effects ◽  
Water Soluble Polymer ◽  
Site Specific ◽  
Novel Drugs

Recently, research and development in the field of drug delivery systems (DDS) facilitating site-specific therapy has reached significant progression. DDS based on polymer micelles, coated micro- and nanoparticles, and various prodrug systems including water-soluble polymer have been prepared and extensively studied as novel drugs designed for cancer chemotherapy and brain delivery. Since polymers are going to be used in human, this study has the interest of testing two types of polymer, polyimides (PI) and polyphenylenevinylene (PPV) on neuronal cells. The objective of this study was to determine the possible neurotoxicity and potential neuroprotective effects of PI and PPV towards SH-SY5Y neuronal cells challenged by hydrogen peroxide (H2O2) as an oxidant. Cells were pretreated with either PI or PPV for 1 hour followed by incubation for 24 hour with 100 µM of H2O2. MTS assay was used to assess cell viability. Results show that PI and PPV are not harmful within the concentration up to 10 µM and 100 µM, respectively. However, PI and PPV do not protect neuronal cells against toxicity induced by H2O2 or further up the cell death.

Disinfection of Fruits with Activated Water

2019 ◽  
Vol 10 ◽  
pp. 1864-1872
Author(s):  
Prof. Teodora P. Popova
Keyword(s):  
Antimicrobial Activity ◽  
Aqueous Solutions ◽  
Antimicrobial Properties ◽  
The Other ◽  
Gram Negative Bacteria ◽  
High Antimicrobial Activity ◽  
Gram Negative ◽  
E Coli ◽  
Number Of Microorganisms ◽  
Lower Effect

The effect of ionized aqueous solutions (anolytes and catholyte) in the processing of fruits (cherries, morellos, and strawberries) for decontamination has been tested. Freshly prepared analytes and catholyte without the addition of salts were used, as well as stored for 7 months anolytes, prepared with 0.5% NaCl and a combination of 0.5% NaCl and 0.5% Na2CO3. The anolyte prepared with a combination of 0.5% NaCl and 0.5% Na2CO3, as well as the anolyte obtained with 0.5% NaCl, exhibit high antimicrobial activity against the surface microflora of strawberries, cherries, and sour cherries. They inactivate E. coli for 15 minutes. The other species of the fam. Enterobacteriaceae were also affected to the maximum extent, as is the total number of microorganisms, especially in cherries and sour cherries. Even stored for 7 months, they largely retain their antimicrobial properties. Anolyte and catholyte, obtained without the addition of salts, showed a lower effect on the total number of microorganisms, but had a significant effect on Gram-negative bacteria, and especially with regard to the sanitary indicative E. coli.

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