A redox-responsive theranostic agent for target-specific fluorescence imaging and photodynamic therapy of EGFR-overexpressing triple-negative breast cancers

2016 ◽  
Vol 4 (42) ◽  
pp. 6787-6790 ◽  
Author(s):  
Jisu Kim ◽  
Youngjae Won ◽  
Sung-Ho Goh ◽  
Yongdoo Choi
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Target Cell ◽  
Triple Negative ◽  
Breast Cancers ◽  
Specific Fluorescence ◽  
Theranostic Agent ◽  
Redox Responsive

A redox-responsive specific theranostic agent for target-cell-specific activatable fluorescence imaging and photodynamic therapy of triple-negative breast cancers.

A redox-responsive mesoporous silica based nanoplatform for in vitro tumor-specific fluorescence imaging and enhanced photodynamic therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Fan Yuan ◽  
Jiang-Lan Li ◽  
Han Cheng ◽  
Xuan Zeng ◽  
Xian-Zheng Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Specific Fluorescence ◽  
Redox Responsive ◽  
Multifunctional Peptides

A mesoporous silica nanoparticle-based redox-responsive platform modified with multifunctional peptides was successfully developed for in vitro tumor microenvironment-enhanced photodynamic therapy.

A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

2018 ◽  
Vol 6 (17) ◽  
pp. 2524-2527 ◽  
Author(s):  
Jisu Kim ◽  
Hyunjin Kim ◽  
Yongdoo Choi
Keyword(s):  
Fluorescence Imaging ◽  
Target Cell ◽  
Imaging Probe ◽  
Redox Responsive

Here, we have developed a redox-responsive folate–fluorophore conjugate with a disulfide linker for the target-specific activatable fluorescence imaging of cancers.

One small molecule as a theranostic agent: naphthalimide dye for subcellular fluorescence localization and photodynamic therapy in vivo

MedChemComm ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1171-1175 ◽  
Author(s):  
Lei Zhang ◽  
Kecheng Lei ◽  
Jingwen Zhang ◽  
Wenlin Song ◽  
Yuanhong Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Small Molecule ◽  
Single Molecule ◽  
Therapeutic Treatment ◽  
Agent Based ◽  
Theranostic Agent ◽  
Bright Fluorescence ◽  
Naphthalimide Dye

A small single-molecule theranostic agent based on naphthalimide was developed, which possessed both bright fluorescence imaging and effective photodynamic therapeutic treatment.

scholarly journals Chitosan oligosaccharide decorated liposomes combined with TH302 for photodynamic therapy in triple negative breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yinan Ding ◽  
Rui Yang ◽  
Weiping Yu ◽  
Chunmei Hu ◽  
Zhiyuan Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Triple Negative ◽  
Chitosan Oligosaccharide ◽  
Antitumor Effects ◽  
Imaging Capability ◽  
Good Biocompatibility

Abstract Background Triple negative breast cancer (TNBC) is an aggressive tumor with extremely high mortality that results from its lack of effective therapeutic targets. As an adhesion molecule related to tumorigenesis and tumor metastasis, cluster of differentiation-44 (also known as CD44) is overexpressed in TNBC. Moreover, CD44 can be effectively targeted by a specific hyaluronic acid analog, namely, chitosan oligosaccharide (CO). In this study, a CO-coated liposome was designed, with Photochlor (HPPH) as the 660 nm light mediated photosensitizer and evofosfamide (also known as TH302) as the hypoxia-activated prodrug. The obtained liposomes can help diagnose TNBC by fluorescence imaging and produce antitumor therapy by synergetic photodynamic therapy (PDT) and chemotherapy. Results Compared with the nontargeted liposomes, the targeted liposomes exhibited good biocompatibility and targeting capability in vitro; in vivo, the targeted liposomes exhibited much better fluorescence imaging capability. Additionally, liposomes loaded with HPPH and TH302 showed significantly better antitumor effects than the other monotherapy groups both in vitro and in vivo. Conclusion The impressive synergistic antitumor effects, together with the superior fluorescence imaging capability, good biocompatibility and minor side effects confers the liposomes with potential for future translational research in the diagnosis and CD44-overexpressing cancer therapy, especially TNBC. Graphic abstract

scholarly journals FDPP–HA as a theranostic agent for cancer-targeted fluorescence imaging and photodynamic therapy

RSC Advances ◽  
2017 ◽  
Vol 7 (59) ◽  
pp. 37369-37373 ◽  
Author(s):  
Pingping Liang ◽  
Jinjun Shao ◽  
Qianyun Tang ◽  
Weili Si ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Tumor Targeting ◽  
Theranostic Agent ◽  
Imaging Properties

FDPP–HA was synthesized for tumor targeting photodynamic therapy. All experiments reveal that FDPP–HA presents excellent biocompatibility, high phototoxicity and specific targeted fluorescence imaging properties.

Ubiquinone-BODIPY nanoparticles for tumor redox-responsive fluorescence imaging and photodynamic activity

2021 ◽  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Selective Activation ◽  
Turn On ◽  
Intracellular Environment ◽  
Redox Responsive ◽  
Photodynamic Activity

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.

Sign in / Sign up

Export Citation Format

Share Document