A redox-responsive mesoporous silica based nanoplatform for in vitro tumor-specific fluorescence imaging and enhanced photodynamic therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Fan Yuan ◽  
Jiang-Lan Li ◽  
Han Cheng ◽  
Xuan Zeng ◽  
Xian-Zheng Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Specific Fluorescence ◽  
Redox Responsive ◽  
Multifunctional Peptides

A mesoporous silica nanoparticle-based redox-responsive platform modified with multifunctional peptides was successfully developed for in vitro tumor microenvironment-enhanced photodynamic therapy.

A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10071-10077 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Ning Ma ◽  
Ren-Xi Zhuo ◽  
Xian-Zheng Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Self Assembly ◽  
Silica Nanoparticle ◽  
Cancer Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Amphiphilic Peptides ◽  
Redox Responsive

A novel redox-responsive mesoporous silica nanoparticle (RRMSN/DOX) capped with amphiphilic peptides by self-assembly was demonstrated for targeting drug delivery in cancer cells.

scholarly journals Biocompatible Mesoporous Silica–Polydopamine Nanocomplexes as MR/Fluorescence Imaging Agent for Light-Activated Photothermal–Photodynamic Cancer Therapy In Vivo

2021 ◽  
Vol 9 ◽  
Author(s):  
Jiahui Lu ◽  
Chen Ni ◽  
Jie Huang ◽  
Yawen Liu ◽  
Yingkai Tao ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Colloidal Stability ◽  
Silica Nanoparticle ◽  
Photothermal Conversion ◽  
Normal Tissues ◽  
Irradiation Power

Conventional cancer phototherapy with single modality suffers from low therapeutic efficacy and undesired posttreatment damage for adjacent normal tissues. Therefore, the lower NIR laser irradiation power is vital to the reduction or preclusion of risk of scalds and burns in normal tissues. Herein, we rationally proposed a novel multifunctional nanocomplex, which enabled good magnetic resonance (MR) imaging contrast effect and promising photothermal conversion efficacy. The prepared core/shell nanocomplexes [MSN-Ce6@PDA (Mn)] were composed of chlorin e6-embedded mesoporous silica/nanoparticle composites as the cores, and then polydopamine and manganese ions were conjugated on the cores to form protective shells. The MSN-Ce6@PDA (Mn) nanocomplexes revealed superior properties in colloidal stability, photothermal conversion, reaction oxygen species generation, magnetic resonance imaging, etc. Under the guidance of MR and fluorescence imaging, these MSN-Ce6@PDA (Mn) nanocomplexes were found to be primarily accumulated in the MDA-MB-231 tumor area. Furthermore, the combined photodynamic and photothermal therapy exhibited strong inhibition to the growth of MDA-MB-231 tumor in vitro and in vivo. Besides, the MSN-Ce6@PDA (Mn) nanocomplexes also exhibited excellent biocompatibility and low damage to the healthy animals. Hence, the results demonstrated that the prepared MSN-Ce6@PDA (Mn) nanocomplex would be a promising potential for multimodal imaging-guided phototherapy.

A redox-responsive mesoporous silica nanoparticle with a therapeutic peptide shell for tumor targeting synergistic therapy

Nanoscale ◽  
2016 ◽  
Vol 8 (37) ◽  
pp. 16702-16709 ◽  
Author(s):  
Dong Xiao ◽  
Jing-Jing Hu ◽  
Jing-Yi Zhu ◽  
Shi-Bo Wang ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Targeting ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Therapeutic Peptide ◽  
Redox Responsive

A redox-responsive theranostic agent for target-specific fluorescence imaging and photodynamic therapy of EGFR-overexpressing triple-negative breast cancers

2016 ◽  
Vol 4 (42) ◽  
pp. 6787-6790 ◽  
Author(s):  
Jisu Kim ◽  
Youngjae Won ◽  
Sung-Ho Goh ◽  
Yongdoo Choi
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Target Cell ◽  
Triple Negative ◽  
Breast Cancers ◽  
Specific Fluorescence ◽  
Theranostic Agent ◽  
Redox Responsive

A redox-responsive specific theranostic agent for target-cell-specific activatable fluorescence imaging and photodynamic therapy of triple-negative breast cancers.

scholarly journals Physicochemical Properties Can Be Key Determinants of Mesoporous Silica Nanoparticle Potency in Vitro

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12062-12079 ◽  
Author(s):  
Dalibor Breznan ◽  
Dharani D. Das ◽  
Christine MacKinnon-Roy ◽  
Stéphane Bernatchez ◽  
Abdelhamid Sayari ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Physicochemical Properties ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle

Intelligent nanoflowers: a full tumor microenvironment-responsive multimodal cancer theranostic nanoplatform

Nanoscale ◽  
2019 ◽  
Vol 11 (33) ◽  
pp. 15508-15518 ◽  
Author(s):  
Xunan Jing ◽  
Yanzi Xu ◽  
Daomeng Liu ◽  
Youshen Wu ◽  
Na Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Redox Responsive

Multistage pH/H2O2/redox-responsive 3D nanoflowers that fully exploit the tumor microenvironment achieve highly specific guided multimode diagnosis with excellent synergistic chemotherapy and photodynamic therapy effects both in vitro and in vivo.

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